<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Chronic mitral regurgitation (MR) is the second valvular heart disease for incidence, which worsening severity gradually affects all cardiac chambers and leads to poor outcome if untreated. The recent development of minimally invasive surgical techniques and percutaneous intervention has reduced the operative risk, allowing a more confident referral of these patients for intervention. Therefore, there is a growing need of reliable markers to select the best therapeutic strategies and to identify the optimal timing for intervention. Myocardial fibrosis (MF) gradually occurs as a result of left atrial and ventricular (LA and LV) remodeling due to MR pressure and volume overload. It has been identified as an index of clinical outcome and arrhythmic risk in patients with MR. Particularly, the assessment of LA fibrosis not only allows to define different MR etiology, but also was associated with prognosis and atrial fibrillation (AF) burden. Nowadays, noninvasive estimation of MF is possible through the use of advanced imaging modalities, particularly cardiac magnetic resonance and speckle tracking echocardiography. This review discusses the role of LA fibrosis as a diagnostic and prognostic marker in patients with MR and its quantification by noninvasive multimodality cardiac imaging.</p>
</abstract>

Chronic mitral regurgitation (MR) is the second valvular heart disease for incidence, which worsening severity gradually affects all cardiac chambers and leads to poor outcome if untreated. The recent development of minimally invasive surgical techniques and percutaneous intervention has reduced the operative risk, allowing a more confident referral of these patients for intervention. Therefore, there is a growing need of reliable markers to select the best therapeutic strategies and to identify the optimal timing for intervention. Myocardial fibrosis (MF) gradually occurs as a result of left atrial and ventricular (LA and LV) remodeling due to MR pressure and volume overload. It has been identified as an index of clinical outcome and arrhythmic risk in patients with MR. Particularly, the assessment of LA fibrosis not only allows to define different MR etiology, but also was associated with prognosis and atrial fibrillation (AF) burden. Nowadays, noninvasive estimation of MF is possible through the use of advanced imaging modalities, particularly cardiac magnetic resonance and speckle tracking echocardiography. This review discusses the role of LA fibrosis as a diagnostic and prognostic marker in patients with MR and its quantification by noninvasive multimodality cardiac imaging.

Left atrial fibrosis: an essential hallmark in chronic mitral regurgitation

Department of Medical Biotechnologies, Division of Cardiology

Division of Cardiac Surgery, „St. Michael” Hospital

„Queen’s” University, Kingston Division of Cardiac Surgery, University of Toronto

Department of Cardiovascular Diseases – AUSL Romagna, Division of Cardiology, „Santa Maria delle Croci” Hospital

Romanian Journal of Cardiology

This work is licensed under the Creative Commons Attribution 4.0 International License.

{"article-title":"Left atrial fibrosis: an essential hallmark in chronic mitral regurgitation"}

Chronic mitral regurgitation (MR) is the second valvular heart disease for incidence, which worsening severity gradually affects all cardiac chambers and leads...

Left atrial fibrosis: an essential hallmark in chronic mitral regurgitation

Article Category: Review

Pubblicato online: 30 apr 2022

Pagine: 36 - 45

DOI: https://doi.org/10.47803/rjc.2021.31.1.36

Parole chiave
left atrial, fibrosis, mitral regurgitation, speckle tracking, cardiac magnetic resonance

© 2021 Maria Concetta Pastore et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Left atrial fibrosis: an essential hallmark in chronic mitral regurgitation

Article Category: Review

Pubblicato online: 30 apr 2022

Pagine: 36 - 45

DOI: https://doi.org/10.47803/rjc.2021.31.1.36

Parole chiaveleft atrial, fibrosis, mitral regurgitation, speckle tracking, cardiac magnetic resonance

© 2021 Maria Concetta Pastore et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
left atrial, fibrosis, mitral regurgitation, speckle tracking, cardiac magnetic resonance