The Protective Effect of HLA-DRB1 and HLA-DQB1 Alleles to ACPA-Positive and RF-Positive RA in Albanian Population

1 Silman AJ, Pearson JE. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res. 2002;4 Suppl 3(Suppl 3):S265-72. https://doi.org/10.1186/ar578 PMid:12110146 Search in Google Scholar

2 Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: A systematic review. Semin Arthritis Rheum. 2006;36(3):182-8. https://doi.org/10.1016/j.semarthrit.2006.08.006 PMid:17045630 Search in Google Scholar

3 Klareskog L, Padyukov L, Lorentzen J, Alfredsson L. Mechanisms of disease: Genetic susceptibility and environmental triggers in the development of rheumatoid arthritis. Nat Clin Pract Rheumatol. 2006;2(8):425-33. https://doi.org/10.1038/ncprheum0249 PMid:16932734 Search in Google Scholar

4 Dadoniene J, Uhlig T, Stropuviene S, Venalis A, Boonen A, Kvien TK. Disease activity and health status in rheumatoid arthritis: A case-control comparison between Norway and Lithuania. Ann Rheum Dis. 2003;62(3):231-5. https://doi.org/10.1136/ard.62.3.231 PMid:12594108 Search in Google Scholar

5 Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet. 1989;36(3):178-82. https://doi.org/10.1111/j.1399-0004.1989.tb03185.x PMid:2676268 Search in Google Scholar

6 Ohmura K, Terao C, Mimori T. Recent advances on the genetics of rheumatoid arthritis: Current topics and the future. Inflamm Regen. 2012;32(3):90-8. Search in Google Scholar

7 Balsa A, Cabezón A, Orozco G, Cobo T, Miranda-Carus E, López-Nevot MA, et al. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res Ther. 2010;12(2):R62. https://doi.org/10.1186/ar2975 PMid:20370905 Search in Google Scholar

8 Vallbracht I, Rieber J, Oppermann M, Förger F, Siebert U, Helmke K. Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Ann Rheum Dis. 2004;63(9):1079-84. https://doi.org/10.1136/ard.2003.019877 PMid:15308516 Search in Google Scholar

9 Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: A study of serial measurements in blood donors. Arthritis Rheum. 2004;50(2):380-6. https://doi.org/10.1002/art.20018 PMid:14872479 Search in Google Scholar

10 Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48(10):2741-9. https://doi.org/10.1002/art.11223 PMid:14558078 Search in Google Scholar

11 van Gaalen FA, van Aken J, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum. 2005;7(3):458-67. https://doi.org/10.1002/art.20316 PMid:15248208 Search in Google Scholar

12 Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, vant Hof M, et al. The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent onset rheumatoid arthritis. Arthritis Rheum. 2000;43(8):1831-5. https://doi.org/10.1002/1529-0131(200008)43:8<1831:AIDANR19>3.0.CO;2-6 PMid:10943873 Search in Google Scholar

13 Swart A, Burlingame RW, Gürtler I, Mahler M. Third generation anti-citrullinated peptide antibody assay is a sensitive marker in rheumatoid factor negative rheumatoid arthritis. Clin Chim Acta. 2012;414:266-72. https://doi.org/10.1016/j.cca.2012.09.015 PMid:23022338 Search in Google Scholar

14 van Venrooij WJ, Hazes JM, Visser H. Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis. Neth J. 2002;60(10):383-8. Search in Google Scholar

15 Niewold TB, Harrison MJ, Paget SA. Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis. QJM. 2007;100(4):193-201. https://doi.org/10.1093/qjmed/hcm015 PMid:17434910 Search in Google Scholar

16 Iain B, McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365(23):2205-19. https://doi.org/10.1056/NEJMra1004965 PMid:22150039 Search in Google Scholar

17 de Vries RR, Huizinga TW, Toes RE. HLA and RA revisited: Citrullinated food for the SE hypothesis, the DR6 effect, and NIMA. Hum Immunol. 2006;67(6):454-9. https://doi.org/10.1016/j.humimm.2006.03.016 PMid:16728269 Search in Google Scholar

18 Barnetche T, Constantin A, Cantagrel A, Cambon-Thomsen A, Gourraud PA. New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: A combined analysis of worldwide samples. Arthritis Res Ther. 2008;10(1):R26. https://doi.org/10.1186/ar2379 PMid:18307784 Search in Google Scholar

19 de Vries RR, van der Woude D, Houwing JJ, Toes RE. Genetics of ACPA-positive rheumatoid arthritis: The beginning of the end? Ann Rheum Dis. 2011;70 Suppl 1:i51-4. https://doi.org/10.1136/ard.2010.138040 PMid:21339219 Search in Google Scholar

20 Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31(3):315-24. https://doi.org/10.1002/art.1780310302 PMid:3358796 Search in Google Scholar

21 Bang H, Egerer K, Gauliard A, Lüthke K, Rudolph PE, Fredenhagen G, et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 2007;56(8):2503-11. https://doi.org/10.1002/art.22817 PMid:17665451 Search in Google Scholar

22 Dejaco C, Klotz W, Larcher H, Duftner C, Schirmer M, Herold M. Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis. Arthritis Res Ther. 2006;8(4):R119. https://doi.org/10.1186/ar2008 PMid:16859519 Search in Google Scholar

23 Nunes JM, Riccio ME, Buhler S, Di D, Currat M, Ries F, et al. Analysis of the HLA population data (AHPD) submitted to the 15^th International Histocompatibility/Immunogenetics Workshop by using the Gene[rate] computer tools accommodating ambiguous data (AHPD project report). Tissue Antigens. 2010;76(1):18-30. https://doi.org/10.1111/j.1399-0039.2010.01469.x PMid:20331842 Search in Google Scholar

24 R Development Core Team. R: A Language and Environment for Statistical Computing. Foundation for Statistical Computing, Vienna, Austria; 2008. Available from: https://www.r-project.org Search in Google Scholar

25 Glantz SA. Primer of Biostatistics. 7^th ed. New York: McGraw-Hill; 2005. Search in Google Scholar

26 van der Helm-van Mil AH, Huizinga TW, Schreuder GM, Breedveld FC, de Vries RR, Toes RE. An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. Arthritis Rheum. 2005;52(9):2637-44. https://doi.org/10.1002/art.21272 PMid:16142711 Search in Google Scholar

27 van der Woude D, Lie BA, Lundström E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ, et al. Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: A meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations. Arthritis Rheum. 2010;62(5):1236-45. https://doi.org/10.1002/art.27366 PMid:20131291 Search in Google Scholar

28 Laivoranta-Nyman S, Mottonen T, Hermann R, Tuokko J, Luukkainen R, Hakala M, et al. HLA-DR-DQ haplotypes and genotypes in Finish patients with rheumatoid arthritis. Ann Rheum Dis. 2004;63(11):1406-12. https://doi.org/10.1136/ard.2003.009969 PMid:15479890 Search in Google Scholar

29 Rice TK, Schork NJ, Rao DC. Methods for handling multiple testing. Adv Genet. 2008;60:293-308. https://doi.org/10.1016/S0065-2660(07)00412-9 PMid:18358325 Search in Google Scholar