The role of hepcidin in regulating iron homeostasis in selected diseases

1Krawiec P, Pac-Kożuchowska E. Rola hepcydyny w metabolizmie żelaza w przebiegu nieswoistych zapaleń jelit. Postępy Hig Med. Dośw. 2014;68:936-943.Krawiec P Pac-Kożuchowska E Rola hepcydyny w metabolizmie żelaza w przebiegu nieswoistych zapaleń jelit Postępy Hig Med. Dośw 201468936 94310.5604/17322693.1111365Search in Google Scholar

2Ganz T. Iron homeostasis: Fitting the puzzle pieces together. Cell Metab. 2008;7(4):288-290. doi: 10.1016/j. cmet.2008.03.008.Ganz T Iron homeostasis: Fitting the puzzle pieces together Cell Metab 200874288 290 10.1016/j.cmet.2008.03.008Open DOISearch in Google Scholar

3Jonker FAM, Te Poel E, Bates I, Boele van Hensbroek M. Anaemia, iron deficiency and susceptibility to infection in children in sub-Saharan Africa, guideline dilemmas. Br J Haematol. 2017;177(6):878-883. doi: 10.111 1/bjh.14593.Jonker FAM Te Poel E Bates I Boele van Hensbroek M Anaemia, iron deficiency and susceptibility to infection in children in sub-Saharan Africa, guideline dilemmas Br J Haematol 20171776878 883 10.1111/bjh.14593Open DOISearch in Google Scholar

4de Pontual L. [Iron and susceptibility to infections]. [Article in French], Arch Pediatr. 2017;24(5S):5S14-5S17. doi: 10.1016/S0929-693X(17)24004-4.de Pontual L [Iron and susceptibility to infections]. [Article in French] Arch Pediatr 2017245S5S14 5S17 10.1016/S0929-693X(17)24004-4Open DOISearch in Google Scholar

5Sazawal S, Black RE, Ramsan M, Chwaya HM, Stoltzfus RJ, Dutta A, Dhingra U, Kabole I, Deb S, Othman MK, Kabole FM. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial. Lancet 2006;367(9505):133-143. doi: 10.1016/S0140-6736(06)67962-2.Sazawal S Black RE Ramsan M Chwaya HM Stoltzfus RJ Dutta A Dhingra U Kabole I Deb S Othman MK Kabole FM Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: Community-based, randomised, placebo-controlled trial Lancet 20063679505133 143 10.1016/S0140-6736(06)67962-2Open DOISearch in Google Scholar

6Wegmüller R, Bah A, Kendall L, Goheen MM, Mulwa S, Cerami C, Moretti D, Prentice AM. Efficacy and safety of hepcidin-based screen-and-treat approaches using two different doses versus a standard universal approach of iron supplementation in young children in rural Gambia: A double-blind randomised controlled trial. BMC Pediatr. 2016;16(1):149. doi: 10.1186/sl2887-016-0689-4.Wegmüller R Bah A Kendall L Goheen MM Mulwa S Cerami C Moretti D Prentice AM Efficacy and safety of hepcidin-based screen-and-treat approaches using two different doses versus a standard universal approach of iron supplementation in young children in rural Gambia: A double-blind randomised controlled trial BMC Pediatr 2016161149 10.1186/sl2887-016-0689-4Open DOISearch in Google Scholar

7Agoro R, Benmerzoug S, Rose S, Bouyer M, Gozzelino R, Garcia I, Ryffel B, Quesniaux VFJ, Mura C. An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates with Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection. J Infect Dis. 2017;216(7):907-918. doi: 10.1093/infdis/ jix366.Agoro R Benmerzoug S Rose S Bouyer M Gozzelino R Garcia I Ryffel B Quesniaux VFJ Mura C An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates with Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection J Infect Dis 20172167907 918 10.1093/infdis/jix36628973651Open DOISearch in Google Scholar

8Michels KR, Zhang Z, Bettina AM, Cagnina RE, Stefanova D, Burdick MD, Vaulont S, Nemeth E, Ganz T, Mehrad B. Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia. JCI Insight. 2017;2(6):e92002. doi: 10.1172/jci.insight.92002.Michels KR Zhang Z Bettina AM Cagnina RE Stefanova D Burdick MD Vaulont S Nemeth E Ganz T Mehrad B Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia JCI Insight 201726e92002 10.1172/jci.insight.92002535849228352667Open DOISearch in Google Scholar

9Budnevsky AV, Esaulenko IE, Ovsyannikov ES, Labzhaniya NB, Voronina EV, Chernov AV. [Anemic syndrome in patients with community-acquired pneumonia]. [Article in Russian]. Klin Med (Mosk). 2016;94(1):56-60.Budnevsky AV Esaulenko IE Ovsyannikov ES Labzhaniya NB Voronina EV Chernov AV [Anemic syndrome in patients with community-acquired pneumonia]. [Article in Russian] Klin Med (Mosk) 201694156 6010.18821/0023-2149-2016-94-1-56-60Search in Google Scholar

10Schoorl M, Snijders D, Schoorl M, Boersma WG, Bartels PC. Transient impairment of reticulocyte hemoglobin content and hepcidin-25 induction in patients with community-acquired pneumonia. Scand J Clin Lab Invest. 2013;73(1):54-60. doi: 10.3109/00365513.2012.735694.Schoorl M Snijders D Schoorl M Boersma WG Bartels PC Transient impairment of reticulocyte hemoglobin content and hepcidin-25 induction in patients with community-acquired pneumonia Scand J Clin Lab Invest 201373154 60 10.3109/00365513.2012.73569423098343Open DOISearch in Google Scholar

11Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016;23(3):189-97. doi: 10.1097/MOH.0000000000000236.Wang CY Babitt JL Hepcidin regulation in the anemia of inflammation Curr Opin Hematol 2016233189 97 10.1097/MOH.0000000000000236499315926886082Open DOISearch in Google Scholar

12Tacke F, Nuraldeen R, Koch A, Strathmann K, Hutschenreuter G, Trautwein C, Strnad P. Iron Parameters Determine the Prognosis of Critically Ill Patients. Crit Care Med. 2016;44(6): 1049-1058. doi: 10.1097/ CCM.0000000000001607.Tacke F Nuraldeen R Koch A Strathmann K Hutschenreuter G Trautwein C Strnad P Iron Parameters Determine the Prognosis of Critically Ill Patients Crit Care Med 2016446 1049 1058 10.1097/CCM.000000000000160726934143Open DOISearch in Google Scholar

13Houamel D, Ducrot N, Lefebvre T, Daher R, Moulouel B, Sari MA, Letteron P, Lyoumi S, Millot S, Tourret J, Bouvet O, Vaulont S, Vandewalle A, Denamur E, Puy H, Beaumont C, Gouya L, Karim Z. Hepcidin as a major component of renal antibacterial defenses against uropathogenic Escherichia coli. J Am Soc Nephrol. 2016;27(3):835-846. doi: 10.1681/ ASN.2014101035.Houamel D Ducrot N Lefebvre T Daher R Moulouel B Sari MA Letteron P Lyoumi S Millot S Tourret J Bouvet O Vaulont S Vandewalle A Denamur E Puy H Beaumont C Gouya L Karim Z Hepcidin as a major component of renal antibacterial defenses against uropathogenic Escherichia coli J Am Soc Nephrol 2016273835 846 10.1681/ASN.2014101035476918726293821Open DOISearch in Google Scholar

14Mahajan G, Sharma S, Chandra J, Nangia A. Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia. Blood Res. 2017;52(3): 212-217. doi: 10.5045/br.2017.52.3.212.Mahajan G Sharma S Chandra J Nangia A Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia Blood Res 2017523 212 217 10.5045/br.2017.52.3.212564151429043237Open DOISearch in Google Scholar

15Weiss G. Anemia of chronic disorders: New diagnostic tools and new treatment strategies. Semin Hematol. 2015;52(4):313--20. doi: 10.1053/j.seminhematol.2015.07.004.Weiss G Anemia of chronic disorders: New diagnostic tools and new treatment strategies Semin Hematol 2015524313 20 10.1053/j.seminhematol.2015.07.00426404443Open DOISearch in Google Scholar

16Stefanova KI, Delcheva GT, Maneva AI, Batalov AZ, Geneva-Popova MG, Karalilova RV, Simitchiev KK. Pathobiochemical mechanisms relating iron homeostasis to parameters of inflammatory activity and autoimmune disorders in rheumatoid arthritis. Folia Med (Plovdiv). 2016;58(4):257-263. doi: 10.1515/folmed-2016-0040.Stefanova KI Delcheva GT Maneva AI Batalov AZ Geneva-Popova MG Karalilova RV Simitchiev KK Pathobiochemical mechanisms relating iron homeostasis to parameters of inflammatory activity and autoimmune disorders in rheumatoid arthritis Folia Med (Plovdiv) 2016584257 263 10.1515/folmed-2016-004028068286Open DOISearch in Google Scholar

17Krawiec P, Mroczkowska-Juchkiewicz A, Pac-Kożuchowska E. Serum hepcidin in children with inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(12):2165-2171. doi: 10.1097/MIB.0000000000001245.Krawiec P Mroczkowska-Juchkiewicz A Pac-Kożuchowska E Serum hepcidin in children with inflammatory bowel disease Inflamm Bowel Dis 201723122165 2171 10.1097/MIB.000000000000124528945637Open DOISearch in Google Scholar

18Huang YH, Kuo HC. Anemia in Kawasaki disease: Hepcidin as a potential biomarker. Dallinger R, ed. Int J Mol Sci. 2017; 18(4):820. doi: 10.3390/ijms18040820.Huang YH Kuo HC Anemia in Kawasaki disease: Hepcidin as a potential biomarker Dallinger R Int J Mol Sci 2017 184820 10.3390/ijms18040820541240428417923Open DOISearch in Google Scholar

19Hutchinson C. A review of iron studies in overweight and obese children and adolescents: a double burden in the young? Eur J Nutr. 2016;55(7):2179-97. doi: 10.1007/ s00394-016-1155-7.Hutchinson C A review of iron studies in overweight and obese children and adolescents: a double burden in the young? Eur J Nutr 20165572179 97 10.1007/s00394-016-1155-726883916Open DOISearch in Google Scholar

20Moreno-Navarrete JM, Moreno M, Puig J, Blasco G, Ortega F, Xifra G, Ricart W, Fernández-Real AM. Hepatic iron content is independently associated with serum hepcidin levels in subjects with obesity. Clin Nutr. 2017;36(5):1434-1439. doi: 10.1016/j.clnu.2016.09.022.Moreno-Navarrete JM Moreno M Puig J Blasco G Ortega F Xifra G Ricart W Fernández-Real AM Hepatic iron content is independently associated with serum hepcidin levels in subjects with obesity Clin Nutr 20173651434 1439 10.1016/j.clnu.2016.09.02227745814Open DOISearch in Google Scholar

21Andrews M, Soto N, Arredondo-Olguin M. Association between ferritin and hepcidin levels and inflammatory status in patients with type 2 diabetes mellitus and obesity. Nutrition. 2015; 31 (1):51-57. doi: 10.1016/j.nut.2014.04.019.Andrews M Soto N Arredondo-Olguin M Association between ferritin and hepcidin levels and inflammatory status in patients with type 2 diabetes mellitus and obesity Nutrition 2015 31 151 57 10.1016/j.nut.2014.04.01925441587Open DOISearch in Google Scholar

22Aregbesola A, Voutilainen S, Virtanen JK, Aregbesola A, Tuomainen TP. Serum hepcidin concentrations and type 2 diabetes. World J Diabetes. 2015;6(7):978-982. doi: 10.4239/wjd.v6.i7.978.Aregbesola A Voutilainen S Virtanen JK Aregbesola A Tuomainen TP Serum hepcidin concentrations and type 2 diabetes World J Diabetes 201567978 982 10.4239/wjd.v6.i7.978449953126185605Open DOISearch in Google Scholar

23Makis A, Hatzimichael E, Papassotiriou I, Voskaridou E. 2017 Clinical trials update in new treatments of β-thalassemia. Am J Hematol. 2016;91(11): 1135-1145. doi: 10.1002/ajh.24530.Makis A Hatzimichael E Papassotiriou I Voskaridou E. 2017 Clinical trials update in new treatments of β-thalassemia Am J Hematol 20169111 1135 1145 10.1002/ajh.2453027502996Open DOISearch in Google Scholar

24Kawabata H. Progress in iron metabolism research. Rinsho Ketsueki The Japanese Journal of Clinical Hematology. 2017;58(10):1864-1871. doi: 10.11406/rinketsu.58.1864.Kawabata H Progress in iron metabolism research Rinsho Ketsueki The Japanese Journal of Clinical Hematology 201758101864 1871 10.11406/rinketsu.58.186428978826Open DOISearch in Google Scholar

25Lyberopoulou A, Chachami G, Gatselis NK, Kyratzopoulou E, Saitis A, Gabeta S, Eliades P, Paraskeva E, Zachou K, Koukoulis GK, Mamalaki A, Dalekos GN, Simos G. Low serum hepcidin in patients with autoimmune liver diseases. PLoS One. 2015;10(8):e0135486. doi: 10.1371/journal.pone.0135486.Lyberopoulou A Chachami G Gatselis NK Kyratzopoulou E Saitis A Gabeta S Eliades P Paraskeva E Zachou K Koukoulis GK Mamalaki A Dalekos GN Simos G Low serum hepcidin in patients with autoimmune liver diseases PLoS One 2015108e0135486 10.1371/journal.pone.0135486453588426270641Open DOISearch in Google Scholar

26Cakir M, Erduran E, Turkmen ES, Aliyazicioglu Y, Reis GP, Cobanoglu U, Demir S. Hepcidin levels in children with chronic liver disease. Saudi J Gastroenterol. 2015;21(5):300-305. doi: 10.4103/1319-3767.166205.Cakir M Erduran E Turkmen ES Aliyazicioglu Y Reis GP Cobanoglu U Demir S Hepcidin levels in children with chronic liver disease Saudi J Gastroenterol 2015215300 305 10.4103/1319-3767.166205463225526458857Open DOISearch in Google Scholar

27Cylwik B, Chrostek L, Szmitkowski M. Wpływ alkoholu na mechanizmy regulacyjne metabolizmu żelaza. [The effect of alcohol on the regulation of iron metabolism]. [Article in Polish]. Pol Merkur Lekarski. 2008;25(147):273-275.Cylwik B Chrostek L Szmitkowski M Wpływ alkoholu na mechanizmy regulacyjne metabolizmu żelaza. [The effect of alcohol on the regulation of iron metabolism]. [Article in Polish] Pol Merkur Lekarski 200825147273 275Search in Google Scholar

28Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122(2-3):78-86. doi: 10.1159/000243791.Nemeth E Ganz T The role of hepcidin in iron metabolism Acta Haematol 20091222-378 86 10.1159/000243791285527419907144Open DOISearch in Google Scholar

29Ueda N, Takasawa K. Role of Hepcidin-25 in chronic kidney disease: Anemia and beyond. Curr Med Chem. 2017;24(14):1417-1452. doi: 10.2174/092986732466617 0316120538.Ueda N Takasawa K Role of Hepcidin-25 in chronic kidney disease: Anemia and beyond Curr Med Chem 201724141417 1452 10.2174/092986732466617 0316120538Open DOISearch in Google Scholar

30Mercadal L, Metzger M, Haymann JP, Thervet E, Boffa JJ, Flamant M, Vrtovsnik F, Houillier P, Froissart M, Stengel B; NephroTest Study Group. The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease. PLoS One. 2014;9(6):e99781. doi: 10.1371/ journal.pone.0099781.Mercadal L Metzger M Haymann JP Thervet E Boffa JJ Flamant M Vrtovsnik F Houillier P Froissart M Stengel B NephroTest Study Group. The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease PLoS One 201496e99781 10.1371/journal.pone.0099781407618924978810Open DOISearch in Google Scholar

31van Eijk LT, John AS, Schwoebel F, Summo L, Vauléon S, Zöllner S, Laarakkers CM, Kox M, van der Hoeven JG, Swinkels DW, Riecke K, Pickkers P. Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans. Blood. 2014;124(17):2643-2646. doi: 10.1182/blood-2014-03-559484.van Eijk LT John AS Schwoebel F Summo L Vauléon S Zöllner S Laarakkers CM Kox M van der Hoeven JG Swinkels DW Riecke K Pickkers P Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans Blood 2014124172643 2646 10.1182/blood-2014-03-559484420827925163699Open DOISearch in Google Scholar

32Reichert CO, da Cunha J, Levy D, Maselli LMF, Bydlowski SP, Spada C. Hepcidin: Homeostasis and diseases related to iron metabolism. Acta Haematol. 2017;137(4):220-236. doi: 10.1159/000471838.Reichert CO da Cunha J Levy D Maselli LMF Bydlowski SP Spada C Hepcidin: Homeostasis and diseases related to iron metabolism Acta Haematol 20171374220 236 10.1159/00047183828514781Open DOISearch in Google Scholar

33Liu J, Sun B, Yin H, Liu S. Hepcidin: A promising therapeutic target for iron disorders: A systematic review. Medicine (Baltimore). 2016;95(14):e3150. doi: 10.1097/ MD.0000000000003150.Liu J Sun B Yin H Liu S Hepcidin: A promising therapeutic target for iron disorders: A systematic review Medicine (Baltimore) 20169514e3150 10.1097/MD.0000000000003150499875527057839Open DOISearch in Google Scholar