Maintenance treatment with trofosfamide in patients with primary bone ewing sarcoma – single center experience

1Rodriguez-Galindo C, Liu T, Krasin MJ, Wu J, Billups CA, Daw NC, Spunt SL, Rao BN, Santana VM, Navid F. Analysis of prognostic factors in Ewing sarcoma family of tumors: review of St. Jude Children’s Research Hospital studies. Cancer 2007 Jul 15;110(2):375-384. Rodriguez-Galindo C Liu T Krasin MJ Wu J Billups CA Daw NC Spunt SL Rao BN Santana VM Navid F. Analysis of prognostic factors in Ewing sarcoma family of tumors: review of St Jude Children’s Research Hospital studies. Cancer 2007 Jul 151102375 38410.1002/cncr.2282117569105Search in Google Scholar

2Rodriguez-Galindo C, Billups CA, Kun LE, Kun LE, Rao BN, Merchant TE, Santana VM, Pappo AS. Survival after recurrence of Ewing tumors. Cancer 2002;94(2):561-569. Rodriguez-Galindo C Billups CA Kun LE Kun LE Rao BN Merchant TE Santana VM Pappo AS Survival after recurrence of Ewing tumors Cancer 2002942561 56910.1002/cncr.1019211900241Search in Google Scholar

3Raciborska A, Bilska K, Drabko K, Chaber R, Sobol G, Pogorzała M, Wyrobek E, Połczyńska K, Rogowska E, Rodriguez-Galindo C, Woźniak W. Validation of a multimodal treatment protocol for Ewing sarcoma – a report from the Polish Pediatric Oncology Group. Pediatr Blood Cancer. 2014 Dec;61(12):2170-2174. Raciborska A Bilska K Drabko K Chaber R Sobol G Pogorzała M Wyrobek E Połczyńska K Rogowska E Rodriguez-Galindo C Woźniak W Validation of a multimodal treatment protocol for Ewing sarcoma – a report from the Polish Pediatric Oncology Group Pediatr Blood Cancer 2014 Dec61122170 217410.1002/pbc.2516725163763Search in Google Scholar

4Ladenstein R, Ötscher U, Le Deley MC, Whelan J, Paulussen M, Oberlin O, van den Berg H, Dirksen U, Hjorth L, Michon J, Lewis I, Craft A, Jürgens H. Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.J Clin Oncol. 2010;28:3284-3291. Ladenstein R Ötscher U Le Deley MC Whelan J Paulussen M Oberlin O van den Berg H Dirksen U Hjorth L Michon J Lewis I Craft A Jürgens H Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial J Clin Oncol 2010283284 329110.1200/JCO.2009.22.986420547982Search in Google Scholar

5Shankar AG, Ashley S, Craft AW, Pinkerton CR. Outcome after relapse in an unselected cohort of children and adolescents with Ewing sarcoma. Med Pediatr Oncol. 2003;40:141-147. Shankar AG Ashley S Craft AW Pinkerton CR Outcome after relapse in an unselected cohort of children and adolescents with Ewing sarcoma Med Pediatr Oncol 200340141 14710.1002/mpo.1024812518341Search in Google Scholar

6Leavey PJ, Mascarenhas L, Marina N, Chen Z, Krailo M, Miser J, Brown K, Tarbell N, Bernstein ML, Granowetter L, Gebhardt M, Grier HE; Children’s Oncology Group. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: a report from the Children’s Oncology Group. Pediatr Blood Cancer 2008;51:334-338. Leavey PJ Mascarenhas L Marina N Chen Z Krailo M Miser J Brown K Tarbell N Bernstein ML Granowetter L Gebhardt M Grier HE; Children’s Oncology Group. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: a report from the Children’s Oncology Group Pediatr Blood Cancer 200851334 33810.1002/pbc.21618272835718506764Search in Google Scholar

7Stahl M, Ranft A, Paulussen M, Bölling T, Vieth V, Bielack S, Görtitz I, Braun-Munzinger G, Hardes J, Jürgens H, Dirksen U. Risk of recurrence and survival after relapse in patients with Ewing sarcoma. Pediatr Blood Cancer 2011;57:549-553. Stahl M Ranft A Paulussen M Bölling T, Vieth V Bielack S Görtitz I, Braun-Munzinger G Hardes J Jürgens H, Dirksen U Risk of recurrence and survival after relapse in patients with Ewing sarcoma Pediatr Blood Cancer 201157549 55310.1002/pbc.2304021442722Search in Google Scholar

8Rodriguez-Galindo C. Ewing sarcoma and its many faces: are we close to a cure? Med Wieku Rozwoj. 2013 Apr-Jun;17(2):113-116. Rodriguez-Galindo C. Ewing sarcoma and its many faces: are we close to a cure? Med Wieku Rozwoj 2013 Apr-Jun172113 116Search in Google Scholar

9Klingebiel T, Boos J, Beske F, Hallmen E, Int-Veen C, Dantonello T, Treuner J, Gadner H, Marky I, Kazanowska B, Koscielniak E. Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial. Pediatr Blood Cancer. 2008 Apr;50(4):739-745. Klingebiel T Boos J Beske F Hallmen E Int-Veen C Dantonello T Treuner J Gadner H Marky I Kazanowska B Koscielniak E Treatment of children with metastatic soft tissue sarcoma with oral maintenance compared to high dose chemotherapy: report of the HD CWS-96 trial Pediatr Blood Cancer 2008 Apr504739 74510.1002/pbc.2149418286501Search in Google Scholar

10Blomqvist C, Wiklund T, Pajunen M, Virolainen M, Elomaa I. Oral trofosfamide: an active drug in the treatment of soft-tissue sarcoma. Cancer Chemother. Pharmacol. (1995) 36: 263. doi:10.1007/BF00685858. Blomqvist C Wiklund T Pajunen M Virolainen M Elomaa I Oral trofosfamide: an active drug in the treatment of soft-tissue sarcoma. Cancer Chemother Pharmacol 1995 36 263 10.1007/BF006858587781149Open DOISearch in Google Scholar

11Kroiss M, Deutschbein T, Schlötelburg W, Ronchi CL, Neu B, Müller HH, Quinkler M, Hahner S, Heidemeier A, Fassnacht M; German Adrenocortical Carcinoma Study Group. Salvage Treatment of Adrenocortical Carcinoma with Trofosfamide. Horm Cancer. 2016 Jun;7(3):211-218. Kroiss M Deutschbein T Schlötelburg W Ronchi CL Neu B Müller HH, Quinkler M Hahner S Heidemeier A Fassnacht M German Adrenocortical Carcinoma Study Group. Salvage Treatment of Adrenocortical Carcinoma with Trofosfamide Horm Cancer 2016 Jun73211 21810.1007/s12672-016-0260-726961793Search in Google Scholar

12Atzpodien J, Morawek L, Fluck M, Reitz M. Bleomycin, vinorelbine and trofosfamide in relapsed stage IV cutaneous malignant melanoma patients. Cancer Chemother Pharmacol. 2009 Oct;64(5):901-905. Atzpodien J Morawek L Fluck M Reitz M Bleomycin, vinorelbine and trofosfamide in relapsed stage IV cutaneous malignant melanoma patients Cancer Chemother Pharmacol 2009 Oct645901 90510.1007/s00280-009-0939-319229537Search in Google Scholar

13Greiner J, Küfer R, Reske SN, Martin V, Döhner H, Ringhoffer M. Metronomic treatment with low-dose trofosfamide leads to a long-term remission in a patient with docetaxel-refractory advanced metastatic prostate cancer. Case Rep Med. 2010:2010:395720. doi: 10.1155/2010/395720. Greiner J Küfer R, Reske SN Martin V Döhner H, Ringhoffer M Metronomic treatment with low-dose trofosfamide leads to a long-term remission in a patient with docetaxel-refractory advanced metastatic prostate cancer Case Rep Med 20102010395720 10.1155/2010/395720285385720396674Open DOISearch in Google Scholar

14Jahnke K, Thiel E, Bechrakis NE, Willerding G, Kraemer DF, Fischer L, Korfel A. Ifosfamide or trofosfamide in patients with intraocular lymphoma. J Neurooncol. 2009 Jun;93(2):213-217. Jahnke K Thiel E Bechrakis NE Willerding G Kraemer DF Fischer L Korfel A Ifosfamide or trofosfamide in patients with intraocular lymphoma J Neurooncol 2009 Jun932213 21710.1007/s11060-008-9761-819099202Search in Google Scholar

15Hartmann JT, Oechsle K, Mayer F, Kanz L, Bokemeyer C. Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas. Anticancer Res. 2003 Mar-Apr;23(2C):1899-1901. Hartmann JT Oechsle K Mayer F Kanz L Bokemeyer C Phase II trial of trofosfamide in patients with advanced pretreated soft tissue sarcomas Anticancer Res 2003 Mar-Apr232C1899 1901Search in Google Scholar

16Laws HJ, van Kaick B, Pape H, Paulussen M, Göbel U. Relapse after high-dose therapy in relapsed Ewing’s tumor patients: effects of maintenance chemotherapy in two selected patients? Onkologie 2003 Dec;26(6):573-577. Laws HJ van Kaick B Pape H Paulussen M Göbel U Relapse after high-dose therapy in relapsed Ewing’s tumor patients: effects of maintenance chemotherapy in two selected patients? Onkologie 2003 Dec266573 57710.1159/00007415414709933Search in Google Scholar

17Kollmannsberger C, Brugger W, Hartmann JT, Maurer F, Böhm P, Kanz L, Bokemeyer C. Phase II study of oral trofosfamide as palliative therapy in pretreated patients with metastatic soft-tissue sarcoma. Anticancer Drug 1999 Jun;10(5):453-456. Kollmannsberger C Brugger W Hartmann JT Maurer F Böhm P, Kanz L Bokemeyer C Phase II study of oral trofosfamide as palliative therapy in pretreated patients with metastatic soft-tissue sarcoma Anticancer Drug 1999 Jun105453 45610.1097/00001813-199906000-0000410477164Search in Google Scholar

18Jurgens C, Weston C, Lewis I et al. Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. Pediatr Blood Cancer 2006;47(l):22-29. Jurgens C Weston C Lewis I et al Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G 99 clinical trial. Pediatr Blood Cancer 200647l22 2910.1002/pbc.2082016572419Search in Google Scholar

19Cash T, Mcllvaine E, Rrailo MD, Lessnick SL, Lawlor ER, Laack N, Sorger J, Marina N, Grier HE, Granowetter L, Womer RB, DuBois SG. Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children’s Oncology Group. Pediatr Blood Cancer. 2016 Oct;63(10):1771-1779. Cash T Mcllvaine E Rrailo MD Lessnick SL Lawlor ER Laack N Sorger J Marina N Grier HE Granowetter L Womer RB DuBois SG Comparison of clinical features and outcomes in patients with extraskeletal versus skeletal localized Ewing sarcoma: A report from the Children’s Oncology Group Pediatr Blood Cancer 2016 Oct63101771 177910.1200/jco.2015.33.15_suppl.10051Search in Google Scholar

20Gunsilius E, Gierlich T, Mross K, Gastl G, Unger C. Palliative chemotherapy in pretreated patients with advanced cancer: oral trofosfamide is effective in ovarian carcinoma. Cancer Invest. 2001;19(8):808-811. Gunsilius E Gierlich T Mross K Gastl G Unger C Palliative chemotherapy in pretreated patients with advanced cancer: oral trofosfamide is effective in ovarian carcinoma Cancer Invest 2001198808 81110.1081/CNV-10010774211768034Search in Google Scholar

21Raciborska A, Bilska K, Rychlowska-Pruszynska M, Drabko K, Chaber R, Pogorzała M, Połczyńska K, Godziński J, Rodriguez-Galindo C, Wożniak W. Internal hemipelvectomy in the management of pelvic Ewing sarcoma – are outcomes better than with radiation therapy? J Pediatr Surg. 2014 0ct;49(10):1500-1504.Raciborska A Bilska K Rychlowska-Pruszynska M Drabko K Chaber R Pogorzała M Połczyńska K Godziński J Rodriguez-Galindo C Wożniak W Internal hemipelvectomy in the management of pelvic Ewing sarcoma – are outcomes better than with radiation therapy? J Pediatr Surg 2014 0ct49101500 150410.1016/j.jpedsurg.2014.04.01325280655Search in Google Scholar

22Reichardt P, Pink D, Tilgner J, Kretzschmar A, Thuss-Patience PC, Dörken B. Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas. Results of a retrospective analysis. Onkologie 2002 Dec;25(6):541-546. Reichardt P Pink D Tilgner J Kretzschmar A Thuss-Patience PC Dörken B. Oral trofosfamide: an active and well-tolerated maintenance therapy for adult patients with advanced bone and soft tissue sarcomas Results of a retrospective analysis. Onkologie 2002 Dec256541 54610.1159/00006862512566899Search in Google Scholar