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Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study

Hua Yang

Hua Yang

Department of Gynecology, The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai, China
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Yang, Hua
  
13 dic 2024
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Categoria dell'articolo: ORIGINAL PAPER
Pubblicato online: 13 dic 2024
Pagine: 491 - 503
Ricevuto: 30 giu 2024
Accettato: 19 set 2024
DOI: https://doi.org/10.33073/pjm-2024-041
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© 2024 Hua Yang, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Fig. 1.

The detailed flowchart of present mendelian randomization analysis.
The detailed flowchart of present mendelian randomization analysis.

Fig. 2.

The forest plot summarized the causality of gut microbiota on the risk of endometriosis.
The forest plot summarized the causality of gut microbiota on the risk of endometriosis.

Fig. 3.

The forest plot summarized the causality of circulating metabolites on the risk of endometriosis.
The forest plot summarized the causality of circulating metabolites on the risk of endometriosis.

Fig. 4.

The forest plot summarized the causality between circulating metabolites and gut microbiota.
The forest plot summarized the causality between circulating metabolites and gut microbiota.

The causality of circulating metabolites on risk of endometriosis_

Exposure Subset IVW/Wald ratio MR Egger Weighted median Horizontal pleiotropy Heterogeneity
α SE p-value α SE p-value α SE p-value ERI SE p-value Q p-value
1-Eicosatrienoylglycero-phosphocholine lipid 0.7316 0.001575 0.02416 2.538 0.7409 0.006486 0.005782 0.002841 0.04843 –0.048 0.018 0.0253 8.367 0.593
1-Oleoylglycero-phosphocholine lipid 1.15 0.4893 0.01871 –1.011 1.023 0.3685 1.157 0.652 0.07597 0.043 0.018 0.0658 1.725 0.8858
2-Aminooctanoic acid amino acid 0.3516 0.1602 0.02819 0.2772 0.262 0.3716 0.3716 0.1729 0.06623 0.004 0.011 0.72 10.64 0.301
3 - Phenylpropionate amino acid –0.6252 0.2425 0.009951 –0.4805 0.3796 0.3331 –0.5788 0.2893 0.04539 –0.0095 0.019 0.669 0.7925 0.6729
Decanoylcarnitine lipid 0.4646 0.1842 0.01166 0.5798 0.3388 0.1307 0.5456 0.2251 0.01536 –0.0055 0.013 0.697 4.314 0.743
Dihomo-linolenate fatty acid –0.7076 0.3451 0.04032 0.05512 0.9978 0.9569 –0.4608 0.4847 0.3418 –0.015 0.018 0.43 12.96 0.3723
Dimethylarginine (SDMA + ADMA) amino acid –1.255 0.4615 0.006548 –2.798 1.317 0.04693 –2.063 0.6368 0.001197 0.017 0.014 0.226 14.04 0.7814
Ergothioneine xenobiotics –1.13 0.4685 0.4685 – – – – – – – – – – –
Hexadecanedioate lipid 0.3527 0.128 0.005867 0.3823 0.1914 0.06711 0.4095 0.1608 0.01088 –0.002 0.0095 0.834 17.36 0.1832
Hexanoylcarnitine lipid 0.4772 0.2379 0.04487 0.4677 0.4768 0.3523 0.4522 0.2656 0.08871 0.00032 0.014 0.982 12.08 0.2089
Octanoylcarnitine lipid 0.4604 0.2092 0.02779 0.4957 0.3655 0.2466 0.4395 0.2324 0.05855 –0.0017 0.015 0.912 0.3964 0.9828
Palmitate (16:0) fatty acid –1.415 0.4277 0.0009344 –2.996 0.9716 0.006741 –0.9829 0.6468 0.1286 0.021 0.011 0.0878 11.85 0.809
Pseudouridine nucleotide –1.312 0.6122 0.03213 1.971 2.362 0.4164 –1.942 0.8565 0.02334 –0.035 0.024 0.17 16.41 0.4244
Stearate (18:0) fatty acid –0.7386 0.3701 0.04598 –0.1354 –0.1354 0.8967 –0.3944 0.5247 0.4522 –0.007 0.011 0.537 15.77 0.8962
Threonine amino acid 0.9348 0.4587 0.04153 0.04153 1.501 1.501 0.6212 0.5832 0.2868 0.011 0.022 0.635 8.823 0.6382

The causality of gut microbiota abundance on risk of endometriosis_

Exposure n SNP IVW MR Egger Weighted median Horizontal pleiotropy Heterogeneity
β se p-value β se p-value β se p-value ERI se p-value Q p-value
class Negativicutes 7 0.002521 0.001072 0.01863 0.005405 0.003049 0.1364 0.002102 0.001445 0.1458 –0.00022 0.00022 0.359 6.198 0.4014
genus Dialister 2 0.003723 0.001718 0.03027 – – – – – – – – – 0.7413 0.3893
genus Enterorhabdus 3 0.002015 0.0009595 0.03575 0.0005135 0.002386 0.8651 0.001771 0.001182 0.134 0.00026 0.00038 0.617 0.7286 0.6947
genus Eubacterium xylanophilum group 7 0.003385 0.000999 0.0007027 –0.001805 –0.001805 0.5773 0.003223 0.001374 0.01897 0.00044 0.00025 0.131 6.42 0.3778
genus Methanobrevibacter 3 0.001948 0.0007719 0.0007719 0.002244 0.003202 0.6108 0.001635 0.001025 0.1107 –0.00005 0.00051 0.938 1.767 0.4134
order Selenomonadales 7 0.002521 0.001072 0.01863 0.005405 0.003049 0.1364 0.1364 0.001445 0.1458 –0.00022 0.00022 0.359 6.198 0.4014
genus Coprococcus 1 7 –0.003294 0.001028 0.001354 –0.001902 0.003123 0.5692 –0.002869 0.001362 0.03517 –0.00011 0.00022 0.657 4.788 0.5713
genus Senegalimassilia 2 –0.003588 0.00158 0.02319 – – – – – – – – – 1.34 0.2471
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