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Characteristics of the Cervicovaginal Microenvironment in Childbearing-Age Women with Different Degrees of Cervical Lesions and HR-HPV Positivity

QINGZHI ZHAI

QINGZHI ZHAI

  • Chinese PLA Medical SchoolBeijing, China
  • Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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ZHAI, QINGZHI
, 
WEIYI ZHANG

WEIYI ZHANG

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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ZHANG, WEIYI
, 
ZHE ZHANG

ZHE ZHANG

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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ZHANG, ZHE
, 
YURONG FU

YURONG FU

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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FU, YURONG
, 
YANG LI

YANG LI

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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LI, YANG
, 
XUEQI WANG

XUEQI WANG

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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WANG, XUEQI
, 
LI’AN LI

LI’AN LI

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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LI, LI’AN
 e 
YUANGUANG MENG

YUANGUANG MENG

Department of Obstetrics and Gynecology, First Medical Center, Chinese PLA General HospitalBeijing, China
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MENG, YUANGUANG
  
20 dic 2021
Characteristics of the Cervicovaginal Microenvironment in Childbearing-Age Women with Different Degrees of Cervical Lesions and HR-HPV Positivity's Cover Image
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Categoria dell'articolo: original-paper
Pubblicato online: 20 dic 2021
Pagine: 489 - 500
Ricevuto: 31 ago 2021
Accettato: 10 nov 2021
DOI: https://doi.org/10.33073/pjm-2021-046
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© 2021 Qingzhi Zhai et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Fig. 1.

Microbiome communities of five groups.
Microbiome communities of five groups.

Fig. 2.

Alpha diversity index of cervical microflora between groups. Group 1 – healthy group; Group 2 – HR-HPV infection group; Group 3 – LSIL group; Group 4 – HSIL group; Group 5 – cervical cancer group.
Alpha diversity index of cervical microflora between groups. Group 1 – healthy group; Group 2 – HR-HPV infection group; Group 3 – LSIL group; Group 4 – HSIL group; Group 5 – cervical cancer group.

Fig. 3.

Beta diversity between five groups; A) beta diversity between groups; B) box plot based on weighted UniFrac beta diversity.
Beta diversity between five groups; A) beta diversity between groups; B) box plot based on weighted UniFrac beta diversity.

Fig. 4.

Abundance heatmap of different speciesat the genus level in phase 1.
Abundance heatmap of different speciesat the genus level in phase 1.

Fig. 5.

Abundance heatmap of different species at the genus level in phase 2.
Abundance heatmap of different species at the genus level in phase 2.

Fig. 6.

Co-occurrence network diagram.
Co-occurrence network diagram.

Analysis of essential information in each group_

GroupCases numberAge BMI
Group 12940.08 ± 4.8323.20 ± 3.47
Group 22942.17 ± 5.1822.00 ± 2.16
Group 33240.63 ± 4.5522.32 ± 2.93
Group 44040.64 ± 5.5722.37 ± 1.62
Group 53842.43 ± 5.3122.88 ± 1.96
K-W test (H) 5.3367.640
K-W test (P) 0.2550.106
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Scienze biologiche, Microbiologia e virologia
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