N-acetylcysteine (NAC) Attenuating Apoptosis and Autophagy in RAW264.7 Cells in Response to Incubation with Mycolic Acid from Bovine Mycobacterium tuberculosis Complex
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Aldini G, Altomare A, Baron G, Vistoli G, Carini M, Borsani L, Sergio F. N-acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why. Free Radic Res. 2018 Jul;52(7):751–762. https://doi.org/10.1080/10715762.2018.1468564AldiniGAltomareABaronGVistoliGCariniMBorsaniLSergioF.N-acetylcysteine as an antioxidant and disulphide breaking agent: The reasons why. 2018Jul;52(7):751–762. https://doi.org/10.1080/10715762.2018.146856410.1080/10715762.2018.146856429742938Search in Google Scholar
Amaral EP, Conceição EL, Costa DL, Rocha MS, Marinho JM, Cordeiro-Santos M, D’Império-Lima MR, Barbosa T, Sher A, Andrade BB. N-acetylcysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions. BMC Microbiol. 2016 Oct 28;16(1):251. https://doi.org/10.1186/s12866-016-0872-7AmaralEPConceiçãoELCostaDLRochaMSMarinhoJMCordeiro-SantosMD’Império-LimaMRBarbosaTSherAAndradeBB.N-acetylcysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions. 2016Oct 28;16(1):251. https://doi.org/10.1186/s12866-016-0872-710.1186/s12866-016-0872-7508444027793104Search in Google Scholar
Baker JJ, Dechow SJ, Abramovitch RB. Acid fasting: modulation of Mycobacterium tuberculosis metabolism at acidic pH. Trends Microbiol. 2019 Nov;27(11):942–953. https://doi.org/10.1016/j.tim.2019.06.005BakerJJDechowSJAbramovitchRB.Acid fasting: modulation of Mycobacterium tuberculosis metabolism at acidic pH. 2019Nov;27(11):942–953. https://doi.org/10.1016/j.tim.2019.06.00510.1016/j.tim.2019.06.005680063231324436Search in Google Scholar
Cerni S, Shafer D, To K, Venketaraman V. Mycobacterium tuberculosis investigating the role of everolimus in mtor inhibition and autophagy promotion as a potential host-directed therapeutic target in infection. J Clin Med. 2019 Feb 11;8(2):232. https://doi.org/10.3390/jcm8020232CerniSShaferDToKVenketaramanV.Mycobacterium tuberculosis investigating the role of everolimus in mtor inhibition and autophagy promotion as a potential host-directed therapeutic target in infection. 2019Feb 11;8(2):232. https://doi.org/10.3390/jcm802023210.3390/jcm8020232640658130754665Search in Google Scholar
Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004 Dec 17;119(6):753–766. https://doi.org/10.1016/j.cell.2004.11.038GutierrezMGMasterSSSinghSBTaylorGAColomboMIDereticV.Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 2004Dec 17;119(6):753–766. https://doi.org/10.1016/j.cell.2004.11.03810.1016/j.cell.2004.11.03815607973Search in Google Scholar
Hardie DG. AMPK-sensing energy while talking to other signaling pathways. Cell Metab. 2014 Dec 2;20(6):939–952. https://doi.org/10.1016/j.cmet.2014.09.013HardieDG.AMPK-sensing energy while talking to other signaling pathways. 2014Dec 2;20(6):939–952. https://doi.org/10.1016/j.cmet.2014.09.01310.1016/j.cmet.2014.09.013569332525448702Search in Google Scholar
Lederer E, Adam A, Ciorbaru R, Petit JF, Wietzerbin J. Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties. Mol Cell Biochem. 1975 May 30; 7(2): 87–104. https://doi.org/10.1007/bf01792076LedererEAdamACiorbaruRPetitJFWietzerbinJ.Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties. 1975May 30; 7(2): 87–104. https://doi.org/10.1007/bf0179207610.1007/BF017920761095912Search in Google Scholar
Lehmann J, Cheng T-Y, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB et al. An antibacterial β-lactone kills Mycobacterium tuberculosis by disrupting mycolic acid biosynthesis. Angew Chem Int Ed Engl. 2018 Jan 2; 57(1):348–353. https://doi.org/10.1002/anie.201709365LehmannJChengT-YAggarwalAParkASZeilerERajuRMAkopianTKandrorOSacchettiniJCMoodyDBAn antibacterial β-lactone kills Mycobacterium tuberculosis by disrupting mycolic acid biosynthesis. 2018Jan 2; 57(1):348–353. https://doi.org/10.1002/anie.20170936510.1002/anie.201709365610482929067779Search in Google Scholar
Li G, Liu G, Song N, Kong C, Huang Q, Su H, Bi A, Luo L, Zhu L, Xu Y et al. A novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice. Mol Immunol. 2015 Aug;66(2):346–356. https://doi.org/10.1016/j.molimm.2015.04.003LiGLiuGSongNKongCHuangQSuHBiALuoLZhuLXuYA novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice. 2015Aug;66(2):346–356. https://doi.org/10.1016/j.molimm.2015.04.00310.1016/j.molimm.2015.04.00325942359Search in Google Scholar
Lin J, Chang Q, Dai X, Liu D, Jiang Y, Dai Y. Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages. Mol Cell Biochem. 2019 Jul;457(1–2):179–189. https://doi.org/10.1007/s11010-019-03522-xLinJChangQDaiXLiuDJiangYDaiY.Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis promotes caspase-9/caspase-3-mediated apoptosis in macrophages. 2019Jul;457(1–2):179–189. https://doi.org/10.1007/s11010-019-03522-x10.1007/s11010-019-03522-x30911956Search in Google Scholar
Liu J, Nikaido H. A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates. Proc Natl Acad Sci USA. 1999 Mar 30;96(7):4011–4016. https://doi.org/10.1073/pnas.96.7.4011LiuJNikaidoH.A mutant of Mycobacterium smegmatis defective in the biosynthesis of mycolic acids accumulates meromycolates. 1999Mar 30;96(7):4011–4016. https://doi.org/10.1073/pnas.96.7.401110.1073/pnas.96.7.40112241110097154Search in Google Scholar
Liu L, Yim H, Choi JH, Kim S-T, Jin Y, Lee SK. ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α – induced apoptosis of HeLa cells. FEBS Lett. 2014 Mar 18;588(6): 929–935. https://doi.org/10.1016/j.febslet.2014.01.050LiuLYimHChoiJHKimS-TJinYLeeSK.ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α – induced apoptosis of HeLa cells. 2014Mar 18;588(6): 929–935. https://doi.org/10.1016/j.febslet.2014.01.05010.1016/j.febslet.2014.01.05024530529Search in Google Scholar
Marrakchi H, Lanéelle M-A, Daffé M. Mycolic acids: structures, biosynthesis, and beyond. Chem Biol. 2014 Jan 16;21(1):67–85. https://doi.org/10.1016/j.chembiol.2013.11.011MarrakchiHLanéelleM-ADafféM.Mycolic acids: structures, biosynthesis, and beyond. 2014Jan 16;21(1):67–85. https://doi.org/10.1016/j.chembiol.2013.11.01110.1016/j.chembiol.2013.11.01124374164Search in Google Scholar
Menon MB, Dhamija S. Beclin 1 phosphorylation – at the center of autophagy regulation. Front Cell Dev Biol. 2018 Oct 12;6:137. https://doi.org/10.3389/fcell.2018.00137MenonMBDhamijaS.Beclin 1 phosphorylation – at the center of autophagy regulation. 2018Oct 12;6:137. https://doi.org/10.3389/fcell.2018.0013710.3389/fcell.2018.00137619499730370269Search in Google Scholar
Mohanty S, Dal Molin M, Ganguli G, Padhi A, Jena P, Selchow P, Sengupta S, Meuli M, Sander P, Sonawane A. Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages. Tuberculosis (Edinb). 2016 Jan;96:44–57. https://doi.org/10.1016/j.tube.2015.11.006MohantySDal MolinMGanguliGPadhiAJenaPSelchowPSenguptaSMeuliMSanderPSonawaneA.Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages. 2016Jan;96:44–57. https://doi.org/10.1016/j.tube.2015.11.00610.1016/j.tube.2015.11.00626786654Search in Google Scholar
Slama N, Jamet S, Frigui W, Pawlik A, Bottai D, Laval F, Constant P, Lemassu A, Cam K, Daffé M et al. The changes in mycolic acid structures caused by hadc mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis. Mol Microbiol. 2016 Feb; 99(4):794–807. https://doi.org/10.1111/mmi.13266SlamaNJametSFriguiWPawlikABottaiDLavalFConstantPLemassuACamKDafféMThe changes in mycolic acid structures caused by hadc mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis. 2016Feb; 99(4):794–807. https://doi.org/10.1111/mmi.1326610.1111/mmi.1326626538472Search in Google Scholar
Wang C, Chen K, Xia Y, Dai W, Wang F, Shen M, Cheng P, Wang J, Lu J, Zhang Y et al. N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PLoS ONE. 2014 Sep 29;9(9):e108855. https://doi.org/10.1371/journal.pone.0108855WangCChenKXiaYDaiWWangFShenMChengPWangJLuJZhangYN-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. 2014Sep 29;9(9):e108855. https://doi.org/10.1371/journal.pone.010885510.1371/journal.pone.0108855418167825264893Search in Google Scholar