<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Oligochaeta <italic>Tubifex tubifex</italic>, fish fathead minnow (<italic>Pimephales promelas</italic>), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different organisms and yet their acute toxicity indices correlate. Correlation equations for special effects were developed for a large heterogeneous series of compounds (QSAR, quantitative structure-activity relationships). Knowing those correlation equations and their statistic evaluation, one can extrapolate the toxic indices. The reason is that a common physicochemical property governs the biological effect, namely the partition coefficient between two unmissible phases, simulated generally by n-octanol and water. This may mean that the transport of chemicals towards a target is responsible for the magnitude of the effect, rather than reactivity, as one would assume suppose.</p></abstract>

Oligochaeta Tubifex tubifex, fish fathead minnow (Pimephales promelas), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different organisms and yet their acute toxicity indices correlate. Correlation equations for special effects were developed for a large heterogeneous series of compounds (QSAR, quantitative structure-activity relationships). Knowing those correlation equations and their statistic evaluation, one can extrapolate the toxic indices. The reason is that a common physicochemical property governs the biological effect, namely the partition coefficient between two unmissible phases, simulated generally by n-octanol and water. This may mean that the transport of chemicals towards a target is responsible for the magnitude of the effect, rather than reactivity, as one would assume suppose.

Extrapolation of toxic indices among test objects

National Institute of Public Health, Šrobárova 48, 10042 Praha 10, Czech Republic

Interdisciplinary Toxicology

{"article-title":"Extrapolation of toxic indices among test objects"}

Oligochaeta Tubifex tubifex, fish fathead minnow (Pimephales promelas), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different...

Extrapolation of toxic indices among test objects

Pubblicato online: 28 gen 2011

Pagine: 137 - 139

DOI: https://doi.org/10.2478/v10102-010-0054-7

Parole chiave
QAAR, QSAR, extrapolation, acute toxicity, oligochaeta, fish, ciliate, hepatocytes

This content is open access.

Extrapolation of toxic indices among test objects

Pubblicato online: 28 gen 2011

Pagine: 137 - 139

DOI: https://doi.org/10.2478/v10102-010-0054-7

Parole chiaveQAAR, QSAR, extrapolation, acute toxicity, oligochaeta, fish, ciliate, hepatocytes

This content is open access.

Parole chiave
QAAR, QSAR, extrapolation, acute toxicity, oligochaeta, fish, ciliate, hepatocytes