Type-2 diabetes mellitus (DM2) is a major risk factor for the development of coronary artery disease (CAD) and subsequent myocardial infarction (MI). Because the pro-inflammatory cytokine tumor necrosis factor α (TNFα) takes part in several stages of the development of atherosclerosis, we investigated the association of the TNFα gene G(-308)A polymorphism with MI in 142 DM2 patients and in 310 patients who had had DM2 for over 10 years with no clinical signs of CAD and measured the serum TNFα levels in 70 consecutive DM2 patients: 10 with MI and 60 without MI.
We found no association between the G(-308)A polymorphism and MI in DM2 [odds ratio (OR) = 0.8, 95% confidence interval (CI) = 0.5-1.3,