<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Development and progression of human malignancies involve multiple genetic changes including chromosomal instabilities such as translocations, deletions, and inversions. Chromosomal abnormalities were observed in 23 cases with ovarian and endometrial cancer by cytogenetic studies using a GTG (G bands by trypsin using Giemsa) banding technique. Specific chromosome bands were frequently involved, and were most frequent on chromosomes 1, 2, 3, 5, 12 and 17. Clonal alterations were observed at the cancer breakpoints, such as 1q21, 1q32, 3p21, 7q22, 11q23 in ovarian and 1p36, 1q32, 2p12, 3p21, 7q22, 9q34, 11p15, 11q23, 12q13, 14q11, 14q32, 16p13, 21q22 in endometrial cases. These findings provide evidence that multiple genetic lesions are associated with the pathogenesis of endometrial and ovarian cancer.</p></abstract>

Development and progression of human malignancies involve multiple genetic changes including chromosomal instabilities such as translocations, deletions, and inversions. Chromosomal abnormalities were observed in 23 cases with ovarian and endometrial cancer by cytogenetic studies using a GTG (G bands by trypsin using Giemsa) banding technique. Specific chromosome bands were frequently involved, and were most frequent on chromosomes 1, 2, 3, 5, 12 and 17. Clonal alterations were observed at the cancer breakpoints, such as 1q21, 1q32, 3p21, 7q22, 11q23 in ovarian and 1p36, 1q32, 2p12, 3p21, 7q22, 9q34, 11p15, 11q23, 12q13, 14q11, 14q32, 16p13, 21q22 in endometrial cases. These findings provide evidence that multiple genetic lesions are associated with the pathogenesis of endometrial and ovarian cancer.

Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas

Department of Medical Biology and Genetics, University of Çukurova, School of Medicine, Adana, Turkey

Department of Obstetrics and Gynecology, University of Çukurova, School of Medicine, Adana, Turkey

Department of Pathology, University of Çukurova, School of Medicine, Adana, Turkey

Balkan Journal of Medical Genetics

{"article-title":"Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas"}

Development and progression of human malignancies involve multiple genetic changes including chromosomal instabilities such as translocations, deletions, and...

Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas

Pubblicato online: 30 mag 2008

Pagine: 61 - 70

DOI: https://doi.org/10.2478/v10034-008-0008-y

Parole chiave
Endometrial cancer, Ovarian cancer, Cytogenetics

This content is open access.

Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas

Pubblicato online: 30 mag 2008

Pagine: 61 - 70

DOI: https://doi.org/10.2478/v10034-008-0008-y

Parole chiaveEndometrial cancer, Ovarian cancer, Cytogenetics

This content is open access.

Parole chiave
Endometrial cancer, Ovarian cancer, Cytogenetics