<abstract xmlns="http://www.w3.org/1999/xhtml"><p>In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.</p></abstract>

In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid lipid nanoparticles (SLN), became a revolutionary approach in the early nineties. The present review is designed to provide an insight into how SLN are finding a niche as promising nanovectors and forms a sound basis to troubleshoot the existing problems associated with traditional systems. Herein, authors had tried to highlight the frontline aspects prominent to SLN. An updated list of lipids, advanced forms of SLN, methods of preparation, characterization parameters, and various routes of administration of SLN are explored in-depth. Stability, toxicity, stealthing, targeting efficiency and other prospectives of SLN are also discussed in detail. The present discussion embodies the potential of SLN, now being looked up by various research groups around the world for their utility in the core areas of pharmaceutical sciences, thereby urging pharmaceutical industries to foster their scale-up.

Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled

R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India

Rajarshi Shahu College of Pharmacy and Research, Pune-411033, India

H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, India

Formulation Research and Development Department, Marksans Pharma., Ltd., Verna Industrial Estate, Verna-403722 India

Baxil Pharma, Pvt. Ltd., Nainital Highway, Shyampur, Haridwar-249408 India

Acta Pharmaceutica

In the era of nanoparticulate controlled and site specific drug delivery systems, use of solid lipids to produce first generation lipid nanoparticles, solid...

Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled

Pubblicato online: 15 gen 2013

Pagine: 433 - 472

DOI: https://doi.org/10.2478/v10007-012-0040-z

Parole chiave
colloidal drug carrier, solid lipid nanoparticles (SLN), stability, targeting efficiency, cytotoxicity, stealthing of SLN

This content is open access.

Solid lipid based nanocarriers: An overview / Nanonosači na bazi čvrstih lipida: Pregled

Pubblicato online: 15 gen 2013

Pagine: 433 - 472

DOI: https://doi.org/10.2478/v10007-012-0040-z

Parole chiavecolloidal drug carrier, solid lipid nanoparticles (SLN), stability, targeting efficiency, cytotoxicity, stealthing of SLN

This content is open access.

Parole chiave
colloidal drug carrier, solid lipid nanoparticles (SLN), stability, targeting efficiency, cytotoxicity, stealthing of SLN