<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 3<sup>2</sup> full factorial design. The microspheres were made by incorporating the drug in a polar organic solvent, which was emulsified using liquid paraffin as an external oil phase. Effects of various process parameters such as viscosity of the external phase, selection of the internal phase, surfactant selection and selection of stirring speed were studied. Microspheres were evaluated for product yield, encapsulation efficiency and particle size. Various drug/ethylcellulose ratios and PEG concentrations were assayed. <italic>In vitro</italic> dissolution profiles showed that ethylcellulose microspheres were able to control release of the drug for a period of 12 h.</p></abstract>

An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 32 full factorial design. The microspheres were made by incorporating the drug in a polar organic solvent, which was emulsified using liquid paraffin as an external oil phase. Effects of various process parameters such as viscosity of the external phase, selection of the internal phase, surfactant selection and selection of stirring speed were studied. Microspheres were evaluated for product yield, encapsulation efficiency and particle size. Various drug/ethylcellulose ratios and PEG concentrations were assayed. In vitro dissolution profiles showed that ethylcellulose microspheres were able to control release of the drug for a period of 12 h.

Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters

Sinhgad College of Pharmacy Vadgaon (Bk), Pune-411041 (MS), India

Acta Pharmaceutica

An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose...

Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters

Pubblicato online: 25 dic 2011

Pagine: 363 - 376

DOI: https://doi.org/10.2478/v10007-011-0032-4

Parole chiave
ropinirol hidroklorid, mikrosfere, etilceluloza, isparavanje otapala, faktorijalno dizajniranje

This content is open access.

Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters

Pubblicato online: 25 dic 2011

Pagine: 363 - 376

DOI: https://doi.org/10.2478/v10007-011-0032-4

Parole chiaveropinirol hidroklorid, mikrosfere, etilceluloza, isparavanje otapala, faktorijalno dizajniranje

This content is open access.

Parole chiave
ropinirol hidroklorid, mikrosfere, etilceluloza, isparavanje otapala, faktorijalno dizajniranje