<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (<bold>2</bold>) was used as the key molecule for preparation of various furopyrimidines <bold>3-9</bold> and formation of spiro-cycloalkane furopyrimidines <bold>10, 11</bold>. Also, poly fused heterocyclic compounds <bold>13-17</bold> were prepared from compound <bold>2</bold>. The synthesized compounds were screened for their antimicrobial activity.</p></abstract>

3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of spiro-cycloalkane furopyrimidines 10, 11. Also, poly fused heterocyclic compounds 13-17 were prepared from compound 2. The synthesized compounds were screened for their antimicrobial activity.

Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems

Photochemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451 Saudi Arabia

Chemistry of Natural and Microbial Product Department, National Research Centre, 12622 Dokki, Cairo, Egypt

Acta Pharmaceutica

3-Amino-5-(4-chlorophenylamino)-4-cyanofuran-2-carboxamide (2) was used as the key molecule for preparation of various furopyrimidines 3-9 and formation of...

Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems

Pubblicato online: 17 dic 2010

Pagine: 479 - 491

DOI: https://doi.org/10.2478/v10007-010-0033-8

Parole chiave
pirimidin, glukopiranozil-pirimidin, oksazin, antimikrobno djelovanje

This content is open access.

Antimicrobial activity of some synthesized glucopyranosyl-pyrimidine carbonitrile and fused pyrimidine systems

Pubblicato online: 17 dic 2010

Pagine: 479 - 491

DOI: https://doi.org/10.2478/v10007-010-0033-8

Parole chiavepirimidin, glukopiranozil-pirimidin, oksazin, antimikrobno djelovanje

This content is open access.

Parole chiave
pirimidin, glukopiranozil-pirimidin, oksazin, antimikrobno djelovanje