<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics, <italic>viz.</italic>, hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied for <italic>in vitro</italic> drug release characteristics for 9 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on <italic>in vitro</italic> characteristics and was used <italic>in vivo</italic> radiographic studies by incorporating BaSO<sub>4</sub>. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for the absorption window drugs.</p></abstract>

Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxypropyl methylcellulose (HPMC K4M, HPMC K100M) and xanthan gum. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied for in vitro drug release characteristics for 9 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for the absorption window drugs.

Development and evaluation of gastroretentive norfloxacin floating tablets

University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India

Natco Pharma Ltd., Kotthur Mahaboobnagar District, India

Acta Pharmaceutica

{"article-title":"Development and evaluation of gastroretentive norfloxacin floating tablets"}

Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared...

Development and evaluation of gastroretentive norfloxacin floating tablets

Pubblicato online: 29 giu 2009

Pagine: 211 - 221

DOI: https://doi.org/10.2478/v10007-009-0019-6

Parole chiave
norfloksacin, plutajuće tablete, vrijeme zadržavanja u želucu, sustav za isporuku lijeka s produljenim zadržavanjem u želucu

This content is open access.

Development and evaluation of gastroretentive norfloxacin floating tablets

Pubblicato online: 29 giu 2009

Pagine: 211 - 221

DOI: https://doi.org/10.2478/v10007-009-0019-6

Parole chiavenorfloksacin, plutajuće tablete, vrijeme zadržavanja u želucu, sustav za isporuku lijeka s produljenim zadržavanjem u želucu

This content is open access.

Parole chiave
norfloksacin, plutajuće tablete, vrijeme zadržavanja u želucu, sustav za isporuku lijeka s produljenim zadržavanjem u želucu