<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Aim</h3>
<p>To make the treatment approach in patients suffering a European hornet sting allergy reaction more personalized, preparing them also for possible future risks.</p>
</sec>
<sec><h3>Methods</h3>
<p>In Slovenia an extended retrospective observational cohort epidemiological study about the natural history of Hymenoptera venom sensitivity is in progress. The study is based on data from the healthcare records of the University Clinic Golnik (UCG) and data collected by a questionnaire sent to patients from May 2019 to April 2021. For a pilot study, we selected patients who were referred to UCG because of an allergic reaction to European hornet sting and had been re-stung later by a wasp (n=68). The association between severe systemic allergic reactions (SSAR) after wasp sting and potential risk factors in subjects with a history of hornet sting allergy was assessed univariately using the likelihood ratio test.</p>
</sec>
<sec><h3>Results</h3>
<p>Among 68 European hornet allergic patients 27 reacted with an SSAR and 41 reacted with a mild SAR. Among 27 patients with SSAR, 4 reacted with an SSAR also to a subsequent wasp sting. Among 41 patients with a mild European hornet sting SAR nobody reacted with an SSAR to a subsequent wasp sting. The association between the severity of the wasp SAR reaction in European hornet allergic patients was statistically significant (p=0.022).</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Our results suggest that patients with severe European hornet SAR should be considered for wasp venom immunotherapy or prophylactic prescription of epinephrine auto-injector as they are at risk for an SSAR also after wasp string.</p>
</sec>
</abstract>

Aim
To make the treatment approach in patients suffering a European hornet sting allergy reaction more personalized, preparing them also for possible future risks.

Methods
In Slovenia an extended retrospective observational cohort epidemiological study about the natural history of Hymenoptera venom sensitivity is in progress. The study is based on data from the healthcare records of the University Clinic Golnik (UCG) and data collected by a questionnaire sent to patients from May 2019 to April 2021. For a pilot study, we selected patients who were referred to UCG because of an allergic reaction to European hornet sting and had been re-stung later by a wasp (n=68). The association between severe systemic allergic reactions (SSAR) after wasp sting and potential risk factors in subjects with a history of hornet sting allergy was assessed univariately using the likelihood ratio test.

Results
Among 68 European hornet allergic patients 27 reacted with an SSAR and 41 reacted with a mild SAR. Among 27 patients with SSAR, 4 reacted with an SSAR also to a subsequent wasp sting. Among 41 patients with a mild European hornet sting SAR nobody reacted with an SSAR to a subsequent wasp sting. The association between the severity of the wasp SAR reaction in European hornet allergic patients was statistically significant (p=0.022).

Conclusion
Our results suggest that patients with severe European hornet SAR should be considered for wasp venom immunotherapy or prophylactic prescription of epinephrine auto-injector as they are at risk for an SSAR also after wasp string.

Risk Factors Associated with Severe Systemic Allergic Reaction after Wasp Sting in Subjects with a History of European Hornet Sting Allergy

University of Ljubljana, Faculty of Medicine

University Clinic of Respiratory and Allergic Diseases Golnik

University of Ljubljana, Faculty of Medicine, Chair of Internal Medicine

University of Ljubljana, Faculty of Medicine, Chair of Public Health

Slovenian Journal of Public Health

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Dejavniki Tveganja, Povezani s Težko Sistemsko Alergijsko Reakcijo (SAR) Po Piku Ose Pri Opazovancih s SAR Po Piku Evropskega Sršena v Anamnezi

Aim
To make the treatment approach in patients suffering a European hornet sting allergy reaction more personalized, preparing them also for possible future...

Risk factor for SSAR after a wasp sting	Category	N_tot	N_hornet/N_cat (%)	p
Severe SAR after European hornet sting	No	68	0/41 (0.0%)	0.005
Severe SAR after European hornet sting	Yes		4/27 (14.8%)	0.005
Gender	Female	68	1/18 (5.6%)	0.945
Gender	Male		3/50 (6.0%)	0.945
Age	0–40	65	3/29 (10.3%)	0.203
Age	41+		1/36 (2.8%)	0.203
Carrying out farm work	No	68	2/34 (5.9%)	1.000
Carrying out farm work	Yes		2/34 (5.9%)	1.000
Type of living environment	Rural	68	2/45 (4.4%)	0.492
Type of living environment	Urban		2/23 (8.7%)	0.492
Family history of Hymenoptera allergy	No	68	3/53 (5.7%)	0.885
Family history of Hymenoptera allergy	Yes		1/15 (6.7%)	0.885
Time between two stings	0–2 years	68	0/25 (0.0%)	0.051
Time between two stings	>3 years		4/43 (9.3%)	0.051
History of asthma	No	68	4/67 (6.0%)	0.727
History of asthma	Yes		0/1 (0.0%)	0.727
Accompanying diseases	No	68	4/60 (6.7%)	0.309
Accompanying diseases	Yes		0/8 (0.0%)	0.309
Concentrations of sIgE	Low	68	1/7 (14.3%)	0.646
	Moderate		2/35 (5.7%)
	High		1/26 (3.8%)

Risk Factors Associated with Severe Systemic Allergic Reaction after Wasp Sting in Subjects with a History of European Hornet Sting Allergy

Article Category: Original scientific article

Pubblicato online: 20 mar 2024

Pagine: 66 - 72

Ricevuto: 25 set 2023

Accettato: 05 dic 2023

DOI: https://doi.org/10.2478/sjph-2024-0010

Parole chiave
Hymenoptera allergy, European hornet sting, Wasp sting, Severe systemic allergic reactions, Healthcare, Public health

© 2024 Simona Perčič et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Results of analysis of association between severe SAR after a wasp sting in hornet sting allergic patients and selected risk.

Risk Factors Associated with Severe Systemic Allergic Reaction after Wasp Sting in Subjects with a History of European Hornet Sting Allergy

Article Category: Original scientific article

Pubblicato online: 20 mar 2024

Pagine: 66 - 72

Ricevuto: 25 set 2023

Accettato: 05 dic 2023

DOI: https://doi.org/10.2478/sjph-2024-0010

Parole chiaveHymenoptera allergy, European hornet sting, Wasp sting, Severe systemic allergic reactions, Healthcare, Public health

© 2024 Simona Perčič et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Results of analysis of association between severe SAR after a wasp sting in hornet sting allergic patients and selected risk.

Parole chiave
Hymenoptera allergy, European hornet sting, Wasp sting, Severe systemic allergic reactions, Healthcare, Public health