<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec id="j_sjph-2019-0022_s_006">
<h3>Background</h3>
<p>The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of age.</p></sec>
<sec id="j_sjph-2019-0022_s_007">
<h3>Methods</h3>
<p>Authors conducted a retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles performed at the Department of Reproductive Medicine and Gynecologic Endocrinology, University Medical Centre Maribor, Slovenia between January 2006 and December 2015 in women aged 40 or more. The characteristics of patients and cycles were compared regarding live birth as the final outcome.</p></sec>
<sec id="j_sjph-2019-0022_s_008">
<h3>Results</h3>
<p>A total of 1920 IVF/ICSI cycles with egg retrieval in women ≥40 years of age were performed leading to 1591 embryo transfers. The live birth rate per embryo transfer was 17.3% at 40, 11.6% at 41, 8.2% at 42, 7.9% at 43, 1.9% at 44 and 0.0% at ≥45 years of age. The multivariate logistic regression model showed that besides women’s age (OR 0.66, 95% CI: 0.55–0.78), the number of previous cycles (OR 0.88, 95% CI: 0.82–0.95), number of good quality embryos on day 2 (OR 1.19, 95% CI: 1.05-1.36), number of embryos transferred (OR 1.57, 95% CI: 1.19–2.07) and day 5 embryo transfer (OR 2.21, 95% CI: 1.37–3.55) were also independent prognostic factors for live birth.</p></sec>
<sec id="j_sjph-2019-0022_s_009">
<h3>Conclusions</h3>
<p>The chance of in vitro fertilization success in women ≥40 years of age should not be estimated only on the woman’s age, but also on other predictive factors: number of previous cycles, number of good quality embryos on day 2, number of transferred embryos and blastocyst embry transfer.</p></sec></abstract>

Background
The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of age.

Methods
Authors conducted a retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles performed at the Department of Reproductive Medicine and Gynecologic Endocrinology, University Medical Centre Maribor, Slovenia between January 2006 and December 2015 in women aged 40 or more. The characteristics of patients and cycles were compared regarding live birth as the final outcome.

Results
A total of 1920 IVF/ICSI cycles with egg retrieval in women ≥40 years of age were performed leading to 1591 embryo transfers. The live birth rate per embryo transfer was 17.3% at 40, 11.6% at 41, 8.2% at 42, 7.9% at 43, 1.9% at 44 and 0.0% at ≥45 years of age. The multivariate logistic regression model showed that besides women’s age (OR 0.66, 95% CI: 0.55–0.78), the number of previous cycles (OR 0.88, 95% CI: 0.82–0.95), number of good quality embryos on day 2 (OR 1.19, 95% CI: 1.05-1.36), number of embryos transferred (OR 1.57, 95% CI: 1.19–2.07) and day 5 embryo transfer (OR 2.21, 95% CI: 1.37–3.55) were also independent prognostic factors for live birth.

Conclusions
The chance of in vitro fertilization success in women ≥40 years of age should not be estimated only on the woman’s age, but also on other predictive factors: number of previous cycles, number of good quality embryos on day 2, number of transferred embryos and blastocyst embry transfer.

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Slovenian Journal of Public Health

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Napovedni dejavniki za živorojenost v avtolognih ciklih zunajtelesne oploditve pri ženskah, starih 40 let in več

Background
The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of...

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Article Category: Original scientific article

Pubblicato online: 01 ott 2019

Pagine: 173 - 178

Ricevuto: 07 nov 2018

Accettato: 08 ago 2019

DOI: https://doi.org/10.2478/sjph-2019-0022

Parole chiave
in vitro fertilization, late reproductive age, pregnancy rate, abortion rate, live birth rate, predictive factors

© 2019 National Institute of Public Health, Slovenia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Article Category: Original scientific article

Pubblicato online: 01 ott 2019

Pagine: 173 - 178

Ricevuto: 07 nov 2018

Accettato: 08 ago 2019

DOI: https://doi.org/10.2478/sjph-2019-0022

Parole chiavein vitro fertilization, late reproductive age, pregnancy rate, abortion rate, live birth rate, predictive factors

© 2019 National Institute of Public Health, Slovenia

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
in vitro fertilization, late reproductive age, pregnancy rate, abortion rate, live birth rate, predictive factors