<abstract xmlns="http://www.w3.org/1999/xhtml">

The aim of this study was to assess and compare the oxidative stress status in STEMI and NSTEMI patients by measuring markers of free radical production and levels of antioxidant. The research was designed as an observational study with a cohort of 83 AMI hospitalized patients divided into a case (STEMI) and control (NSTEMI) group. In the study, we used the data from the patients’ electronic medical records and paper files and two scores (TIMI, and GRACE) analyzed routine biochemical parameters and biochemical assays for ROS. The statistical analysis included descriptive methods, hypothesis testing and bivariate correlation. In our research, the results clearly showed that patients with STEMI had an increased activity of vSOD compared with NSTEMI patients (p&lt;0.01). Also, the levels of TBARS in plasma of patients with STEMI were significantly increased compared to the NSTEMI patients (p&lt;0.01). Importantly, there were no differences between STEMI patients and NSTEMI patients, for the levels of O2−, H2O2, NO, CAT, GSH. In STEMI patients, we found a positive correlation between TBARS and troponin level and a positive correlation between SOD and troponin level. In addition, our results also showed a positive correlation between AST levels and TBARS and a positive correlation between AST levels and SOD. We also found a positive correlation between GRACE score values and TBARS and SOD. Our study demonstrated that the levels of TBARS and SOD were significantly higher in STEMI patients than in NSTEMI.
</abstract>

The aim of this study was to assess and compare the oxidative stress status in STEMI and NSTEMI patients by measuring markers of free radical production and levels of antioxidant. The research was designed as an observational study with a cohort of 83 AMI hospitalized patients divided into a case (STEMI) and control (NSTEMI) group. In the study, we used the data from the patients’ electronic medical records and paper files and two scores (TIMI, and GRACE) analyzed routine biochemical parameters and biochemical assays for ROS. The statistical analysis included descriptive methods, hypothesis testing and bivariate correlation. In our research, the results clearly showed that patients with STEMI had an increased activity of vSOD compared with NSTEMI patients (p<0.01). Also, the levels of TBARS in plasma of patients with STEMI were significantly increased compared to the NSTEMI patients (p<0.01). Importantly, there were no differences between STEMI patients and NSTEMI patients, for the levels of O2−, H2O2, NO, CAT, GSH. In STEMI patients, we found a positive correlation between TBARS and troponin level and a positive correlation between SOD and troponin level. In addition, our results also showed a positive correlation between AST levels and TBARS and a positive correlation between AST levels and SOD. We also found a positive correlation between GRACE score values and TBARS and SOD. Our study demonstrated that the levels of TBARS and SOD were significantly higher in STEMI patients than in NSTEMI.

Oxidative Stress in Acute Myocardial Infarction Patients

University of Kragujevac, Faculty of Medical Sciences

University Clinical Centre “Kragujevac”

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Oxidative Stress in Acute Myocardial Infarction Patients"}

The aim of this study was to assess and compare the oxidative stress status in STEMI and NSTEMI patients by measuring markers of free radical production and...

Oxidative Stress in Acute Myocardial Infarction Patients

Pubblicato online: 11 apr 2024

Pagine: 51 - 56

Ricevuto: 21 gen 2021

Accettato: 25 gen 2021

DOI: https://doi.org/10.2478/sjecr-2021-0008

Parole chiave
Acute myocardial infarction, oxidative stress, free radical, troponin

© 2024 Jovan Jovanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Oxidative Stress in Acute Myocardial Infarction Patients

Pubblicato online: 11 apr 2024

Pagine: 51 - 56

Ricevuto: 21 gen 2021

Accettato: 25 gen 2021

DOI: https://doi.org/10.2478/sjecr-2021-0008

Parole chiaveAcute myocardial infarction, oxidative stress, free radical, troponin

© 2024 Jovan Jovanovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
Acute myocardial infarction, oxidative stress, free radical, troponin