<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The aim of this study was to determine whether early commencement of clean intermittent catheterisation can improve impaired kidney function in children with continent vesicostomy as well as to analyse the effect of different types of continent vesicostomy and the observed outcome. All children with continent urinary derivation performed at the University Children’s Hospital in Belgrade, Serbia, during the period 1990-2016, were included in this retrospective-prospective study. The participants were divided into three groups with respect to type of continent vesicostomy (appendicovesicostomy, preputial continent vesicostomy, and vesicostomy using distal ureter). Clean Intermittent Catheterisation with continent vesicostomy, oxybutynin, and antibiotic prophylaxis were used in a standard way. Renal function was monitored by the value of glomerular filtration rate taken before the start of the therapy and three years afterward. The significance of differences was tested by the paired-samples t-test and ANOVA test. We analysed 74 patients aged 3 to 10 years (5.5-y average) of which 80% were boys. Renal function improved in 60.5% patients. A highly significant improvement in kidney function three years after the commencement of combined treatment was shown irrespective of the performed method of vesicostomy (p&lt;0.01). Using the ANOVA test, we have proved that there is no difference in the efficiency of therapy between particular groups (p= 0,256). The timely started therapy lead to significant kidney function improvement. The type of continent vesicostomy did not affect kidney function.</p>
</abstract>

The aim of this study was to determine whether early commencement of clean intermittent catheterisation can improve impaired kidney function in children with continent vesicostomy as well as to analyse the effect of different types of continent vesicostomy and the observed outcome. All children with continent urinary derivation performed at the University Children’s Hospital in Belgrade, Serbia, during the period 1990-2016, were included in this retrospective-prospective study. The participants were divided into three groups with respect to type of continent vesicostomy (appendicovesicostomy, preputial continent vesicostomy, and vesicostomy using distal ureter). Clean Intermittent Catheterisation with continent vesicostomy, oxybutynin, and antibiotic prophylaxis were used in a standard way. Renal function was monitored by the value of glomerular filtration rate taken before the start of the therapy and three years afterward. The significance of differences was tested by the paired-samples t-test and ANOVA test. We analysed 74 patients aged 3 to 10 years (5.5-y average) of which 80% were boys. Renal function improved in 60.5% patients. A highly significant improvement in kidney function three years after the commencement of combined treatment was shown irrespective of the performed method of vesicostomy (p<0.01). Using the ANOVA test, we have proved that there is no difference in the efficiency of therapy between particular groups (p= 0,256). The timely started therapy lead to significant kidney function improvement. The type of continent vesicostomy did not affect kidney function.

Evolution of Impaired Renal Function in Children After Continent Vesicostomy

University of Kragujevac, Faculty of Medical Sciences

Department of Surgery, Clinic of Pediatric Surgery, Clinical Centre Kragujevac

Department of Surgery, Clinical Center Kragujevac, Clinic for General Surgery

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Evolution of Impaired Renal Function in Children After Continent Vesicostomy"}

The aim of this study was to determine whether early commencement of clean intermittent catheterisation can improve impaired kidney function in children with...

Evolution of Impaired Renal Function in Children After Continent Vesicostomy

Pubblicato online: 11 apr 2024

Pagine: 33 - 37

Ricevuto: 12 dic 2020

Accettato: 25 gen 2021

DOI: https://doi.org/10.2478/sjecr-2021-0001

Parole chiave
Clean intermittent catheterisation, continent vesicostomy, renal function, children

© 2024 Milan Paunovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Evolution of Impaired Renal Function in Children After Continent Vesicostomy

Pubblicato online: 11 apr 2024

Pagine: 33 - 37

Ricevuto: 12 dic 2020

Accettato: 25 gen 2021

DOI: https://doi.org/10.2478/sjecr-2021-0001

Parole chiaveClean intermittent catheterisation, continent vesicostomy, renal function, children

© 2024 Milan Paunovic et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
Clean intermittent catheterisation, continent vesicostomy, renal function, children