[
1. Bomford R. Immunomodulators from plants and fungi. Phytother Res. 1988; 2(4):159-64.10.1002/ptr.2650020402
]Search in Google Scholar
[
2. Saroj P, Verma M, Jha K, Pal M. An overview on immunomodulation. J Adv Sci Res. 2012; 3(1):7-12.
]Search in Google Scholar
[
3. Jantan I, Ahmad W, Bukhari SN. Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci. 2015; 6:655.10.3389/fpls.2015.00655454809226379683
]Search in Google Scholar
[
4. Dobrange E, Peshev D, Loedolff B, Van den Ende W. Fructans as Immunomodulatory and Antiviral Agents: The Case of Echinacea. Biomolecules. 2019; 9(10):615.10.3390/biom9100615684340731623122
]Search in Google Scholar
[
5. Jaradat NA. Review of the taxonomy, ethnobotany, phytochemistry, phytotherapy and phytotoxicity of germander plant (Teucrium polium L.). Medicine. 2015; 3:4.
]Search in Google Scholar
[
6. Esmaeili MA, Yazdanparast R. Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets. J Ethnopharm. 2004; 95(1):27-30.10.1016/j.jep.2004.06.02315374603
]Search in Google Scholar
[
7. Ljubuncic P, Dakwar S, Portnaya I, et al. Aqueous extracts of Teucrium polium possess remarkable antioxidant activity in vitro. Evid Based Complement Alternat Med. 2006; 3(3):329-38.10.1093/ecam/nel028151315116951717
]Search in Google Scholar
[
8. Darabpour E, Motamedi H, Nejad SMS. Antimicrobial properties of Teucrium polium against some clinical pathogens. Asian Pac J Trop Med. 2010; 3(2):124-7.10.1016/S1995-7645(10)60050-8
]Search in Google Scholar
[
9. Rajabalian S. Methanolic extract of Teucrium polium L potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines. Exp Oncol. 2008; 30(2):133-8.
]Search in Google Scholar
[
10. Tariq M, Ageel A, Al-Yahya M, Mossa J, Al-Said M. Anti-inflammatory activity of Teucrium polium. Int J Tissue React. 1989; 11(4):185-8.
]Search in Google Scholar
[
11. Brunt EM. Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond. Hepatology. 2000; 31(1):241-6.10.1002/hep.51031013610613753
]Search in Google Scholar
[
12. Stankovic MS, Niciforovic N, Mihailovic V, Topuzovic M, Solujic S. Antioxidant activity, total phenolic content and flavonoid concentrations of different plant parts of Teucrium polium L. subsp. polium. Acta Soc Bot Pol. 2012; 81(2):117-122.10.5586/asbp.2012.010
]Search in Google Scholar
[
13. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2):55-63.10.1016/0022-1759(83)90303-46606682
]Search in Google Scholar
[
14. Verma A, Prasad KN, Singh AK, et al. Evaluation of the MTT lymphocyte proliferation assay for the diagnosis of neurocysticercosis. J Microbiol Methods. 2010; 81(2): 175-8.10.1016/j.mimet.2010.03.00120211664
]Search in Google Scholar
[
15. Petruzziello A, Samantha M, Loquercio G, Cozzolino A, Cacciapuoti C. Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol. 2016; 22:7824.10.3748/wjg.v22.i34.7824501638327678366
]Search in Google Scholar
[
16. Organization WH. Global health sector strategy on viral hepatitis 2016-2021. Towards ending viral hepatitis. World Health Organization; 2016.
]Search in Google Scholar
[
17. Santantonio T, Wiegand J, Gerlach JT. Acute hepatitis C: current status and remaining challenges. J Hepatol. 2008; 49(4):625-33.10.1016/j.jhep.2008.07.00518706735
]Search in Google Scholar
[
18. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med. 2001; 345(1):41-52.10.1056/NEJM20010705345010711439948
]Search in Google Scholar
[
19. Thimme R, Bukh J, Spangenberg HC, et al. Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci USA. 2002; 99(24):15661-8.10.1073/pnas.20260829913777312441397
]Search in Google Scholar
[
20. B Dustin L. Innate and adaptive immune responses in chronic HCV infection. Curr Drug Targets. 2017; 18(7): 826-43.10.2174/1389450116666150825110532562583826302811
]Search in Google Scholar
[
21. Iken K, Huang L, Bekele H, Schmidt EV, Koziel MJ. Apoptosis of activated CD4+ and CD8+ T cells is enhanced by co-culture with hepatocytes expressing hepatitis C virus (HCV) structural proteins through FasL induction. Virology. 2006; 346(2):363-72.10.1016/j.virol.2005.11.017286519016336987
]Search in Google Scholar
[
22. Barathan M, Mohamed R, Yong YK, et al. Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion. Cells. 2018; 7(10):165.10.3390/cells7100165621037030322028
]Search in Google Scholar
[
23. Luxenburger H, Neumann-Haefelin C, Thimme R, Boettler T. HCV-specific T cell responses during and after chronic HCV infection. Viruses. 2018; 10(11):645.10.3390/v10110645626578130453612
]Search in Google Scholar
[
24. Saeidi A, Zandi K, Cheok YY, et al. T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses. Front Immunol. 2018; 9:2569.10.3389/fimmu.2018.02569623793430473697
]Search in Google Scholar
[
25. Brattig NW, Diao GJ, Berg PA. Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis. Int J Immunopharmacol. 1984; 6(3):205-15.10.1016/0192-0561(84)90018-36746173
]Search in Google Scholar
[
26. Chiang L-C, Ng LT, Chiang W, Chang M-Y, Lin C-C. Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. Planta Med. 2003; 69(07): 600-4.10.1055/s-2003-4111312898413
]Search in Google Scholar
[
27. Norian R, Delirezh N, Azadmehr A. Evaluation of proliferation and cytokines production by mitogen-stimulated bovine peripheral blood mononuclear cells. Vet Res Forum. 2015; 6(4):265-71.
]Search in Google Scholar
[
28. Jose J, Sudhakaran S, Sumesh Kumar TM, Jayaraman S, Jayadevi Variyar E. Study of in vitro immunomodulatory effect of flavonoid isolated from Phyllanthus niruri on human blood lymphocytes and evaluation of its antioxidant potential. Int J Pharmacogn Phytochem Res. 2014; 6(2): 284-9.
]Search in Google Scholar
[
29. Berg AU, Baron DP, Berg PA. Immunomodulating properties of cianidanol on responsiveness and function of human peripheral blood T-cells and K-cells. Int J Immunopharmacol. 1988; 10(4):387-94.10.1016/0192-0561(88)90125-72971631
]Search in Google Scholar
[
30. Vallotton JJ, Frei PC. Influence of (+)-cyanidanol-3 on the leukocyte migration inhibition test carried out in the presence of purified protein derivative and hepatitis B surface antigen. Infect Immun. 1981; 32(2):432-7.10.1128/iai.32.2.432-437.19813514617251131
]Search in Google Scholar
[
31. Ruckstuhl M, Beretz A, Anton R, Landry Y. Flavonoids are selective cyclic GMP phosphodiesterase inhibitors. Biocheml pharma. 1979; 28(4):535-8.10.1016/0006-2952(79)90249-1218594
]Search in Google Scholar