<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The cause of acute and severe hypoxia of the organism is acute posthemorrhagic anemia. To eliminate posthemorrhagic anemia in animals, the perfluorocarbon blood substitute Perftoran (Russia) with a gas-transporting function was used. The aim of this study was to determine the clinical effectiveness of the perfluorocarbon based blood substitute Perftoran with a gas-carrying function in acute posthemorrhagic anemia in animals and reveal possible side effect of the blood substitute and remove them. In the study conducted in the Clinic of Veterinary Medicine of Pushchino Research Center (Russia) participated 20 cats of both sexes, who were admitted with internal bleeding as a result of injuries. The animals were divided into two groups: the control and the treatment groups (10 per group). All animals with anemia were examined according to the standard scheme: anamnesis vitae and anamnesis morbi, physical examination (basic methods of research were used), additional methods that were used: complete blood count (CBC) and biochemical analysis of blood (BA), microscopy of blood smears, abdominal ultrasonography. Based on the obtained results, we can conclude that the use of the gas-carrying substitute for donor blood Perftoran in the treatment group of animals with posthemorrhagic anemia, which resulted from polytrauma, eliminated tissue hypoxia; the treatment of the animals in the control group with standard solutions (by infusing Stabisol) without gas transport correction led to the development of persistent hypoxia, which persisted to the stage of reticulocyte crisis.</p></abstract>

The cause of acute and severe hypoxia of the organism is acute posthemorrhagic anemia. To eliminate posthemorrhagic anemia in animals, the perfluorocarbon blood substitute Perftoran (Russia) with a gas-transporting function was used. The aim of this study was to determine the clinical effectiveness of the perfluorocarbon based blood substitute Perftoran with a gas-carrying function in acute posthemorrhagic anemia in animals and reveal possible side effect of the blood substitute and remove them. In the study conducted in the Clinic of Veterinary Medicine of Pushchino Research Center (Russia) participated 20 cats of both sexes, who were admitted with internal bleeding as a result of injuries. The animals were divided into two groups: the control and the treatment groups (10 per group). All animals with anemia were examined according to the standard scheme: anamnesis vitae and anamnesis morbi, physical examination (basic methods of research were used), additional methods that were used: complete blood count (CBC) and biochemical analysis of blood (BA), microscopy of blood smears, abdominal ultrasonography. Based on the obtained results, we can conclude that the use of the gas-carrying substitute for donor blood Perftoran in the treatment group of animals with posthemorrhagic anemia, which resulted from polytrauma, eliminated tissue hypoxia; the treatment of the animals in the control group with standard solutions (by infusing Stabisol) without gas transport correction led to the development of persistent hypoxia, which persisted to the stage of reticulocyte crisis.

Use of Perfluorocarbon based Blood Substitute Perftoran in Correction of Hypoxia During Acute Anemia in Animals

I.M. Sechenov First Moscow State Medical University (Sechenov University)

The Federal state budgetary institution “The Federal bureau for medical-social expertise” of Ministry of labour and social protection of the Russian Federation (FSBI FB MSE of Mintrud of Russia)

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The cause of acute and severe hypoxia of the organism is acute posthemorrhagic anemia. To eliminate posthemorrhagic anemia in animals, the perfluorocarbon...

Use of Perfluorocarbon based Blood Substitute Perftoran in Correction of Hypoxia During Acute Anemia in Animals

Pubblicato online: 07 nov 2019

Pagine: 245 - 250

Ricevuto: 20 giu 2018

Accettato: 25 lug 2018

DOI: https://doi.org/10.2478/sjecr-2018-0056

Parole chiave
perfluorocarbon blood substitute, hypoxia, cats

© 2019 Sergey Vladimirovich Votrin et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Use of Perfluorocarbon based Blood Substitute Perftoran in Correction of Hypoxia During Acute Anemia in Animals

Pubblicato online: 07 nov 2019

Pagine: 245 - 250

Ricevuto: 20 giu 2018

Accettato: 25 lug 2018

DOI: https://doi.org/10.2478/sjecr-2018-0056

Parole chiaveperfluorocarbon blood substitute, hypoxia, cats

© 2019 Sergey Vladimirovich Votrin et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
perfluorocarbon blood substitute, hypoxia, cats