<abstract xmlns="http://www.w3.org/1999/xhtml"><p> We reported a case of a 22-year-old male patient with swallowing difficulties and double vision. He was diagnosed on the basis of a positive pharmacological test, damage to the postsynaptic neuromuscular junction and computed tomography of the thorax. Tests for antibodies targeted to acetylcholine receptors and to muscle-specific tyrosine kinase were negative. A partial improvement in neurological findings following treatment with pyridostigmine bromide, cyclosporine and methylprednisolone was notedadministered. Th e patient responded favourably to plasma exchange with a withdrawal of all clinical symptoms, confirming the hypothesis that humoral factors may underlie the pathogenesis of double-negative MG .</p></abstract>

We reported a case of a 22-year-old male patient with swallowing difficulties and double vision. He was diagnosed on the basis of a positive pharmacological test, damage to the postsynaptic neuromuscular junction and computed tomography of the thorax. Tests for antibodies targeted to acetylcholine receptors and to muscle-specific tyrosine kinase were negative. A partial improvement in neurological findings following treatment with pyridostigmine bromide, cyclosporine and methylprednisolone was notedadministered. Th e patient responded favourably to plasma exchange with a withdrawal of all clinical symptoms, confirming the hypothesis that humoral factors may underlie the pathogenesis of double-negative MG .

The Clinical Outcome and Therapeutic Treatment of a Patient with Double Seronegative Myasthenia Gravis

Clinic of neurology, Clinical center Kragujevac, Zmaj Jovina 30, 34 000 Kragujevac, Serbia

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

We reported a case of a 22-year-old male patient with swallowing difficulties and double vision. He was diagnosed on the basis of a positive pharmacological...

The Clinical Outcome and Therapeutic Treatment of a Patient with Double Seronegative Myasthenia Gravis

Pubblicato online: 23 apr 2014

Pagine: 43 - 45

DOI: https://doi.org/10.2478/sjecr-2014-0007

Parole chiave
seronegative Myasthenia gravis, anti-LRP4 autoantibodies

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Clinical Outcome and Therapeutic Treatment of a Patient with Double Seronegative Myasthenia Gravis

Pubblicato online: 23 apr 2014

Pagine: 43 - 45

DOI: https://doi.org/10.2478/sjecr-2014-0007

Parole chiaveseronegative Myasthenia gravis, anti-LRP4 autoantibodies

© 2014

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
seronegative Myasthenia gravis, anti-LRP4 autoantibodies