A Case Report of Pediatric Langerhans Cell Histiocytosis: Current Approach and Diagnostic Challenges for Dermatologist

1. Allen CE, Ladisch S, McClain KL. How I treat Langer-hans cell histiocytosis. Blood. 2015;126(1):26-35.10.1182/blood-2014-12-569301449219525827831Search in Google Scholar

2. Lau SK, Chu PG, Weiss LM. lmmunohistochemical expression of Langerin in Langerhans cell histiocytosis and non-Langerhans cell histiocytic disorders. Am J Surg Pathol. 2008;32(4):615-9.10.1097/PAS.0b013e31815b212b18277880Search in Google Scholar

3. Hutter C, Minkov M. Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies. Immunotargets Ther. 2016;5:81-91.10.2147/ITT.S91058506685027785447Search in Google Scholar

4. Tran G, Huynh TN, Paller AS. Langerhans cell histiocytosis: a neoplastic disorder driven by Ras-ERK pathway mutations. J Am Acad Dermatol. 2018;78(3):579-90.10.1016/j.jaad.2017.09.02229107340Search in Google Scholar

5. Favara BE, Jaffe R. The histopathology of Langerhans cell histiocytosis. Br J Cancer Suppl. 1994;23:S17-23.Search in Google Scholar

6. Steen AE, Steen KH, Bauer R, Bieber T. Successful treatment of cutaneous Langerhans cell histiocytosis with low-dose methotrexate. Br J Dermatol. 2001;145 (1):137-40.10.1046/j.1365-2133.2001.04298.x11453923Search in Google Scholar

7. Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Aricò M, et al. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood. 2013;121(25):5006-14.10.1182/blood-2012-09-45577423589673Search in Google Scholar

8. Minkov M. An update on the treatment of pediatric-onset Langerhans cell histiocytosis through pharmacotherapy. Expert Opin Pharmacother. 2018;19(3):233-42.10.1080/14656566.2018.142940529355432Search in Google Scholar

9. Gadner H, Grois N, Pötschger U, Minkov M, Aricò M, Braier J, et al. Improved outcome in multisystem Lang-erhans cell histiocytosis is associated with therapy intensification. Blood. 2008;111(5):2556-62.10.1182/blood-2007-08-10621118089850Search in Google Scholar

10. Behera B, Malathi M, Prabhakaran N, Divya K, Thappa DM, Srinivas BH. Dermoscopy of Langerhans cell histiocytosis. J Am Acad Dermatol. 2017;76(2S1):S79-81.10.1016/j.jaad.2016.09.04228087041Search in Google Scholar

11. Kanik-Yuksek S, Ozkaya-Parlakay A, Gulhan B, Ozyoruk D, Karakus E, Cinel G, et al. A rare diagnosis in children: isolated pulmonary Langerhans cell histiocytosis. Clin Respir J. 2018;12(1):355-6.10.1111/crj.1248027067531Search in Google Scholar

12. Ladisch S. Treating Langerhans cell histiocytosis, globally. Pediatr Blood Cancer. 2018;65(8):e27079.10.1002/pbc.27079Search in Google Scholar

13. James WD, Berger TG, Elston DM, Neuhaus I. Andrews’ diseases of the skin: clinical dermatology. 12th ed. Edinburgh: Elsevier; 2016. p. 722-5.Search in Google Scholar

14. Fitzpatrick TB, Goldsmith LA, Wolff K. Fitzpatrick’s dermatology in general medicine. 8th ed. New York: McGraw-Hill. 2012. p. 1782-95.Search in Google Scholar

15. Hande KR. Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer. 1998;34(10):1514-21.10.1016/S0959-8049(98)00228-7Search in Google Scholar

16. Pommier Y, Leo E, Zhang H, Marchand C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010;17(5):421-33.10.1016/j.chembiol.2010.04.012Search in Google Scholar

17. Pinkus GS, Lones MA, Matsumura F, Yamashiro S, Said JW, Pinkus JL. Langerhans cell histiocytosis: immunohistochemical expression of fascin, a dendritic cell marker. Am J Clin Pathol. 2002;118(3):335-43.10.1309/N2TW-ENRB-1N1C-DWL0Search in Google Scholar

18. Ravi S. Treatment of adult onset multifocal single system Langerhans cell histiocytosis using single agent induction chemotherapy followed by maintenance oral etoposide and external beam radiotherapy. Int J Sci Res (Ahmedabad). 2016;5(6):74-6.Search in Google Scholar

19. Felix CA, Blatt J. Etoposide and Langerhans cell histiocytosis: second malignancies, a second look. Pediatr Hematol Oncol. 1999;16(3):183-5.10.1080/088800199277236Search in Google Scholar

20. Bolognia J, Jorizzo JL, Schaffer JV. Dermatology. 4th ed. Philadelphia: Elsevier Saunders; 2018. p. 1614-20.Search in Google Scholar

21. Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, et al. A randomized trial of treatment for multisystem Langerhans cell histiocytosis. J Pediatr. 2001;138(5):728-34.10.1067/mpd.2001.111331Search in Google Scholar

22. Ng Wing Tin S, Martin-Duverneuil N, Idbaih A, Garel C, Ribeiro M, Parker JL, et al. Efficacy of vinblastine in central nervous system Langerhans cell histiocytosis: a nationwide retrospective study. Orphanet J Rare Dis. 2011;6:83.10.1186/1750-1172-6-83Search in Google Scholar

23. Schmitt AR, Wetter DA, Camilleri MJ, Khan SP, Tollefson MM. Langerhans cell histiocytosis presenting as a blueberry muffin rash. Lancet. 2017;390(10090):155.10.1016/S0140-6736(17)30564-0Search in Google Scholar