<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia cutis can have varied cutaneous presentations such as papules, macules, nodules, plaques and ulcers. We report a case of 52-year-old woman who presented with erythematous macules and papules over her trunk, thighs and upper arms. A skin punch biopsy showed monomorphic, perivascular and periadnexal infiltration by the cells positive for CD45, CD15, CD68 and lysozyme. According to the subsequent bone marrow biopsy and immunophenotypic analysis of peripheral blood cells, the diagnosis of acute monocytic leukemia (FAB AML-M5b) was made. In our case, the first clinical sign suggestive of the diagnosis of leukemia was the presence of erythematous macules and papules. Therefore, we believe that leukemia cutis should be taken into consideration in the differential diagnosis of maculopapular rush on the trunk, upper arms and leg</p></abstract>

Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia cutis can have varied cutaneous presentations such as papules, macules, nodules, plaques and ulcers. We report a case of 52-year-old woman who presented with erythematous macules and papules over her trunk, thighs and upper arms. A skin punch biopsy showed monomorphic, perivascular and periadnexal infiltration by the cells positive for CD45, CD15, CD68 and lysozyme. According to the subsequent bone marrow biopsy and immunophenotypic analysis of peripheral blood cells, the diagnosis of acute monocytic leukemia (FAB AML-M5b) was made. In our case, the first clinical sign suggestive of the diagnosis of leukemia was the presence of erythematous macules and papules. Therefore, we believe that leukemia cutis should be taken into consideration in the differential diagnosis of maculopapular rush on the trunk, upper arms and leg

Leukemia Cutis – A Case Report

Department of Dermatology, Medical Faculty

Institute of Pathology and Forensic Medicine

Department of Hematology, Medical Faculty

Serbian Journal of Dermatology and Venereology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Leukemia Cutis \u2013 A Case Report"}

Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia...

Leukemia Cutis – A Case Report

Pubblicato online: 28 mar 2019

Pagine: 119 - 123

Ricevuto: 28 ago 2018

Accettato: 04 set 2018

DOI: https://doi.org/10.2478/sjdv-2018-0017

Parole chiave
Leukemia, Monocytic, Acute, Skin Neoplasms, Exanthema, Diagnosis, Differential, Case Reports

© 2018 Dušan Mihajlović et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Leukemia Cutis – A Case Report

Pubblicato online: 28 mar 2019

Pagine: 119 - 123

Ricevuto: 28 ago 2018

Accettato: 04 set 2018

DOI: https://doi.org/10.2478/sjdv-2018-0017

Parole chiaveLeukemia, Monocytic, Acute, Skin Neoplasms, Exanthema, Diagnosis, Differential, Case Reports

© 2018 Dušan Mihajlović et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Leukemia, Monocytic, Acute, Skin Neoplasms, Exanthema, Diagnosis, Differential, Case Reports