[
1. Duffy, D. Elon Musk says SpaceX will get humans to Mars in 2026. https://www.businessinsider.co.za/elon-musk-spacex-starship-humans-mars-mission-2026-experts-question-2021-2. Accessed 11th May 2021.
]Search in Google Scholar
[
2. Mars One Roadmap. https://www.mars-one.com/mission/roadmap. Accessed 11th May 2021.
]Search in Google Scholar
[
3. How Investing in the Moon Prepares NASA for First Human Mission to Mars. https://www.nasa.gov/sites/default/files/atoms/files/moon-investments-prepare-us-for-mars.pdf. Accessed 1th May 2021.
]Search in Google Scholar
[
4. Braddock, M, Wilhelm, CP, Romain, A, Bale L, Szocik, K. Application of socio-technical systems models to Martian colonisation and society build. Theoret. Issues Ergonomics Sci. 21, 2019, pp.131-152.10.1080/1463922X.2019.1658242
]Search in Google Scholar
[
5. Vincente, K.J. Cognitive work analysis: towards safe, productive and health computer-based work. CRC press, 1999.
]Search in Google Scholar
[
6. Naikar, N. Work domain analysis: concepts, guidelines and cases. CRC press, 2013.
]Search in Google Scholar
[
7. Cooper, M., Douglas, D. & Perchonok, M. Developing the NASA food system for long-duration missions. J. Food Sci. 76, 2011, R40-R48.10.1111/j.1750-3841.2010.01982.x21535783
]Search in Google Scholar
[
8. Verseux, C., Lima, I.G.P., Baque, M., Rothschild, M. Synthetic Biology for Space Exploration: Promises and Societal Implications. In: Ambivalences of Creating Life. Societal and Philosophical Dimensions of Synthetic Biology. Hagen, K., Engelhard, M., Toepfer (eds.), Springer-Verlag publishers, 2016, pp. 73-100.
]Search in Google Scholar
[
9. Ishimatsu, T., Grogan, P., de Weck, O. Interplanetary Trajectory Analysis and Logistical Considerations of Human Mars Exploration J. Cosmol. 12, 2010, pp, 3588-3600.
]Search in Google Scholar
[
10. Ogawa, N., Haruki, M., Kondoh, Y. et al. Orbit plan and mission design for Mars EDL and surface exploration technologies demonstrator. Trans. JSASS Aerospace Tech. 14, 2016, pp. 9-15.10.2322/tastj.14.Pk_9
]Search in Google Scholar
[
11. Hohmann, W. The Attainability of Heavenly Bodies. In: NASA Technical Translation, F-44, 1960.
]Search in Google Scholar
[
12. Jones, H.W. The recent large reduction in space launch cost. In: 48th International Conference on Environmental Systems, 2018, CES-2018-81, pp. 1-10.
]Search in Google Scholar
[
13. Roberts, T.G. Space Launch to Low Earth Orbit: How Much Does It Cost? Civil and Commercial Space Space Security, 2020 https://aerospace.csis.org/data/space-launch-to-low-earth-orbit-how-much-does-it-cost/, accessed 28th April 2021.
]Search in Google Scholar
[
14. World population projections. https://www.worldometers.info/world-population/world-population-projections/. Accessed 11th May 2021.
]Search in Google Scholar
[
15. Eydelman, A. Temperature on the surface of Mars. The Physics Factbook. Elert, G. (ed.), 2001.
]Search in Google Scholar
[
16. Mars facts, NASA (2013). https://web.archive.org/web/20130607140708/http:/quest.nasa.gov/aero/planetary/mars.html. Accessed April 28th 2021.
]Search in Google Scholar
[
17. Mars fact sheet, NASA (2018). https://nssdc.gsfc.nasa.gov/planetary/factsheet/marsfact.html. Accessed May 10th 2021.
]Search in Google Scholar
[
18. Matthiä, D. et al. The radiation environment on the surface of Mars – Summary of model calculations and comparison to RAD data. Life Sci. Space Res., 14, 2017, pp. 18-28.10.1016/j.lssr.2017.06.00328887939
]Search in Google Scholar
[
19. Bloshenko, A.D., Robinson, J.M., Colon, R.A., Anchordoqui, L.A. Health threat from cosmic radiation during manned missions to Mars. arXiv:2012.09604v1.
]Search in Google Scholar
[
20. Paris, J., Davis, E.T., Tognetti, L., Zahniser, C. Prospective Lava Tubes at Hellas Planitia, J. Wash. Acad. Sci. 2004.13156, 2019.
]Search in Google Scholar
[
21. Voroney, R.P., Heck, R. J. The soil habitat. In: Soil microbiology, ecology and biochemistry (3rd ed.). Eldor, P.A. (ed.). Amsterdam, the Netherlands: Elsevier publishers. 2007, pp. 25–49.10.1016/B978-0-08-047514-1.50006-8
]Search in Google Scholar
[
22. Needelman, B. A. What Are Soils? Nature Education Knowledge 4, 2013, 2.
]Search in Google Scholar
[
23. Kalev, S.D., Toor, G.S. Chapter 3.9 - The Composition of soils and sediments. In: Green Chemistry. Torok, B., Dransfield, T. (eds.) Elsevier publishers, 2018, pp. 339-357.10.1016/B978-0-12-809270-5.00014-5
]Search in Google Scholar
[
24. McSween, H.Y., Taylor, G.J., Wyatt, M.B. Elemental Composition of the Martian Crust. Science, 324, 2009, pp. 736-739.10.1126/science.116587119423810
]Search in Google Scholar
[
25. Cousin, A., Meslin, P.Y., Wiens, R.C. et al. Compositions of coarse and fine particles in martian soils at gale: A window into the production of soils. Icarus, 249, 2015, pp.22-42.10.1016/j.icarus.2014.04.052
]Search in Google Scholar
[
26. Ming, D. W., Morris, R. V. Dust in the Atmosphere of Mars and Its Impact on Human Exploration. In: Proceedings of the LPI, contribution No. 1966, 2017, id.6027.
]Search in Google Scholar
[
27. Bohle, S., Montaño, H.S.P., Bille, M., Turnbull, D. Evolution of soil on Mars. Astron. & Geophys., 57, 2016, pp. 2.18–2.23.10.1093/astrogeo/atw071
]Search in Google Scholar
[
28. Ramkissoon, N.K., Pearson, V.K., Schwenzer, S.P. et al. New simulants for Martian regolith: Controlling iron variability. Planetary Space. Sci., 179, 2019, 104722.10.1016/j.pss.2019.104722
]Search in Google Scholar
[
29. Braddock, M. Mission to Mars: Countdown to Building a Brave New World – Laying the Foundations. In: Yearbook of Astronomy. Jones, B. (ed.), White Owl publishers 2022, In press.
]Search in Google Scholar
[
30. Hecht, M. H., Kounaves, S.P., Quinn, R.C. et al. Detection of perchlorate and the soluble chemistry of Martian soil at the Phoenix Lander Site. Science 325, 2009, pp. 64–67.10.1126/science.117246619574385
]Search in Google Scholar
[
31. Davila, A.F., Willson, D., Coates, J.D. & McKay, C.P. Perchlorate on Mars: a chemical hazard and a resource for humans. Int. J. Astrobiol. 12, 2013, pp 321-325.10.1017/S1473550413000189
]Search in Google Scholar
[
32. Glavin, D., Grotzinger, J.P. Evidence for perchlorates and the origin of chlorinated hydrocarbons detected by SAM at the Rocknest aeolian deposit in Gale Crater. J. Geophys. Res. Planets 118, 2013, pp.1955–1973.10.1002/jgre.20144
]Search in Google Scholar
[
33. Niziński P, Błażewicz A, Kończyk J, Michalski R. Perchlorate - properties, toxicity and human health effects: an updated review. Rev. Environ. Health. 2020, doi: 10.1515/reveh-2020-0006.10.1515/reveh-2020-000632887207
]Search in Google Scholar
[
34. He, H., Gao, H. Chen, G. et al. Effects of perchlorate on growth of four wetland plants and its accumulation in plant tissues. Environ. Sci. Poll. Res. Int. 20, 2013, pp. 7301-7308.10.1007/s11356-013-1744-423673920
]Search in Google Scholar
[
35. Wadsworth, J., Cockell, C.S. Perchlorates on Mars enhance the bacteriocidal effects of UV light. Sci. Rep. 7, 2017, 4662.
]Search in Google Scholar
[
36. Carrier, B.L. Kounaves, S.P. The origins of perchlorate in the Martian soil. Geophys. Res. Lett. 42, 2015, pp. 3739–3745.10.1002/2015GL064290
]Search in Google Scholar
[
37. Race, M.S., Moses, J., McKay, C., Venkateswaran, K.J. Synthetic biology in space: considering the broad societal and ethical implications. Int. J. Astrobiol. 11, 2012, pp. 133-139.10.1017/S1473550412000018
]Search in Google Scholar
[
38. Menezes, A.A., Montague, M.G., Cumbers, J., Hogan, J.A., Arkin, A.P. Grand challenges in space synthetic biology. J. R. Soc. Interface 12, 2015, 20150803.10.1098/rsif.2015.0803470785226631337
]Search in Google Scholar
[
39. Llorente, B., Williams, T.C., Goold, H.D. The multiplanetary future of plant synthetic biology. Genes, 9, 2018, 348.10.3390/genes9070348607103129996548
]Search in Google Scholar
[
40. McNulty, M.J., Xiong, Y., Yates, K. et al. Molecular pharming to support human life on the moon, Mars, and beyond. Preprints 2020, 2020090086.10.20944/preprints202009.0086.v1
]Search in Google Scholar
[
41. Nangle, S.N., Wolfson, M.Y., Hartsough, L. et al. The case for biotech on Mars. Nat. Biotechnol. 38, 2020, pp. 401–407.10.1038/s41587-020-0485-432265561
]Search in Google Scholar
[
42. Patel, Z.S., Brunstetter, T.J., Tarver, W.J. Red risks for a journey to the red planet: the highest priority human health risks for a mission to Mars. npj Microgravity 6, 2020, 33.10.1038/s41526-020-00124-6764568733298950
]Search in Google Scholar
[
43. Duncan, P.B., Morrison, R.D., Vavricka, E. Forensic identification of anthropogenic and naturally occurring sources of perchlorate. Environ. Forensics. 6, 2005, pp.205–215.10.1080/15275920590952883
]Search in Google Scholar
[
44. Cole-Dai, J., Peterson, K.M., Kennedy, J.A., Cox, T.S., Ferris, D.G. Evidence of influence of human activities and volcanic eruptions on environmental perchlorate from a 300-year Greenland ice core record. Environmental Science & Technology, 52, 2018, pp. 8373–8380.10.1021/acs.est.8b0189029943569
]Search in Google Scholar
[
45. Acevedo-Barrios, R., Sabater-Marco, C., Olivero-Verbel, J. Ecotoxicological assessment of perchlorate using in vitro and in vivo assays. Environmental Science and Pollution Research, 25, 2018, pp. 13697–13708.10.1007/s11356-018-1565-629504076
]Search in Google Scholar
[
46. Maffini, M.V., Trasande, L., Neltner, T.G. Perchlorate and diet: human exposures, risks, and mitigation strategies. Current Environmental Health Reports, 3, 2016 pp. 107–117.10.1007/s40572-016-0090-327029550
]Search in Google Scholar
[
47. Smith, P.N. In: The Ecotoxicology of Perchlorate in the Environment BT-Perchlorate: Environmental Occurrence, Interactions and Treatment, Gu, B and Coates, J.D. (eds.), Boston, USA, Springer publishers 2006.
]Search in Google Scholar
[
48. Knight, B.A., Shields, B.M., He, X. et al. Effect of perchlorate and thiocyanate exposure on thyroid function of pregnant women from South-West England: a cohort study. Thyroid Res., 11, 2018, 9.10.1186/s13044-018-0053-x603547630002731
]Search in Google Scholar
[
49. Steinmaus, C., Pearl, M., Kharrazi, M. et al. Thyroid hormones and moderate exposure to perchlorate during pregnancy in women in southern California. Environ. Health Perspect., 124, 2016, pp. 861–867.10.1289/ehp.1409614489291326485730
]Search in Google Scholar
[
50. Srinivasan, A., Viraraghavan, T. Perchlorate: health effects and technologies for its removal from water resources. Int. J. Environ. Res. Public Health 6, 2009, pp 1418-1442.10.3390/ijerph6041418268119119440526
]Search in Google Scholar
[
51. Orris, G.J., Harvey, G.J., Tsui, D.T., Eldrige, J.E. Preliminary analyses for perchlorate in selected natural materials and their derivative products. USGS, 2003. https://www.fws.gov/uploadedFiles/AR%200025%202003%20Preliminary%20analyses%20for%20perchlorate%20in%20selected%20natural%20materials%20and%20their%20derivative%20products.pdf accessed on 10th May 2021.
]Search in Google Scholar
[
52. Wang, O., Coates, J.D. Biotechnological Applications of Microbial (Per)chlorate Reduction. Microorganisms. 5, 2017, pp, 76.10.3390/microorganisms5040076574858529186812
]Search in Google Scholar
[
53. Arkin, A. A Synthetic Biology Architecture to Detoxify and Enrich Mars Soil for Agriculture, 2017. https://www.nasa.gov/directorates/spacetech/niac/2017_Phase_I_Phase_II/Mars_Soil_Agriculture/. Accessed on April 27th 2021.
]Search in Google Scholar
[
54. Venturelli, O S; Egbert, R G; Arkin, A P. Towards engineering biological systems in a broader context. J. Mol. Biol., 428, 2016, pp. 928–944.10.1016/j.jmb.2015.10.02526546279
]Search in Google Scholar
[
55. Enrichment of Martian regolith to useful agricultural soil. https://cubes.space/divisions/mmfd. Accessed May 11th 2021.
]Search in Google Scholar
[
56. Orosei, R., Lauro, S.E., Pettinelli, E. et al. Radar evidence for subglacial liquid water on Mars. Science, 361, 2018, pp. 490-493.10.1126/science.aar726830045881
]Search in Google Scholar
[
57. Nazari-Sharavian, M., Aghababaei, M., Karakouzian, M., Karami, M. Water on Mars – a literature review. Galaxies 8, 2020, 40.10.3390/galaxies8020040
]Search in Google Scholar
[
58. Joseph, R., Gibson, C.H., Schild, R. Water, ice, mud in the Gale crater: implications for life on Mars. J. Cosmol. 29, 2020, pp. 1-33.10.1515/astro-2020-0019
]Search in Google Scholar
[
59. Scheller, E.L., Ehlmann, B.L., Hu, R., Adams, D.J., Yung, Y.L. Long-term drying of Mars by sequestration of ocean-scale volumes of water in the crust. Science, 372, 2021, pp. 56-62.10.1126/science.abc7717837009633727251
]Search in Google Scholar
[
60. Rosa, L. et al. Global agricultural economic water scarcity. Science Advances 6, 2020, eaaz6031.10.1126/sciadv.aaz6031719030932494678
]Search in Google Scholar
[
61. Mekonnen, M.M., Gerbens-Leenes, W. The water footprint of global food production. Water 12, 2020, 2696.10.3390/w12102696
]Search in Google Scholar
[
62. Yang, X., Cushman, J.C., Borland, A.M., Liu, Q. Editorial: Systems Biology and Synthetic Biology in Relation to Drought Tolerance or Avoidance in Plants. Front. Plant Sci. 11, 2020, 394.10.3389/fpls.2020.00394716143132328077
]Search in Google Scholar
[
63. Głowacka, K., Kromdijk, J., Kucera, K. et al. Photosystem II Subunit S overexpression increases the efficiency of water use in a field-grown crop. Nat. Commun. 9, 2018, 868.10.1038/s41467-018-03231-x584041629511193
]Search in Google Scholar
[
64. Park, S.-Y. et al. Agrochemical control of plant water use using engineered abscisic acid receptors. Nature, 520, 2015, pp. 545-548.10.1038/nature1412325652827
]Search in Google Scholar
[
65. Sanghera, G.S., Wani, S.H., Hussain, W., Singh, N.N. Engineering cold stress tolerance in crop plants. Curr. Genomics 12, 2011, pp. 30-43.10.2174/138920211794520178312904121886453
]Search in Google Scholar
[
66. Wisniewski, M., Nassuth, A., Arora, R. (2018). Cold hardiness in trees: a mini-review. Front. Plant Sci. 9, 2018, 1394.
]Search in Google Scholar
[
67. Joshi R., Singh, B., Chinnusamy, V. Genetically Engineering Cold Stress-Tolerant Crops: Approaches and Challenges. In: Cold Tolerance in Plants, Wani S., Herath V. (eds). Springer, Cham. 2020, pp. 179-195.10.1007/978-3-030-01415-5_10
]Search in Google Scholar
[
68. Singh, A,, Grover, A. Genetic engineering for heat tolerance in plants. Physiol. Mol. Biol. Plants. 14, 2008, pp. 155-166.10.1007/s12298-008-0014-2355065523572882
]Search in Google Scholar
[
69. Jia, Y., Ding, Y., Shi Y. et al. The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis. New Phytol. 212, 2016, pp. 345–353.10.1111/nph.1408827353960
]Search in Google Scholar
[
70. Zhao C., Zhang Z., Xie S., Si T., Li Y., Zhu J. K. Mutational evidence for the critical role of CBF transcription factors in cold acclimation in Arabidopsis. Plant Physiol. 171, 2016, pp. 2744–2759.10.1104/pp.16.00533497228027252305
]Search in Google Scholar
[
71. Kumar SR, Kiruba R, Balamurugan S, Cardoso HG, Birgit A-S, et al. Carrot antifreeze protein enhances chilling tolerance in transgenic tomato. Acta Physiologiae Plantarum, 36, 2014, pp. 21-27.10.1007/s11738-013-1383-x
]Search in Google Scholar
[
72. Zaidi, S.SeA., Mahas, A., Vanderschuren, H. et al. Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants. Genome Biol. 21, 2020, 289.10.1186/s13059-020-02204-y770269733256828
]Search in Google Scholar
[
73. Bouis, H. E., Saltzman, A. Improving nutrition through biofortification: A review of evidence from HarvestPlus, 2003 through 2016. Glob. Food Sec.12, 2017, pp.49-58.10.1016/j.gfs.2017.01.009543948428580239
]Search in Google Scholar
[
74. Bhullar, N.K. Gruissem, W. Nutritional enhancement of rice for human health: the contribution of biotechnology. Biotechnol. Adv. 31, 2013, pp. 50-57.10.1016/j.biotechadv.2012.02.00122343216
]Search in Google Scholar
[
75. Ye, X., Al-Babili, S., Klöti, A. et al. Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287, 2000, pp. 303–305.10.1126/science.287.5451.30310634784
]Search in Google Scholar
[
76. Paine, J.A., Shipton, C.A., Chaggar, S. et al. Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat. Biotechnol. 23, 2005, pp. 482–487.10.1038/nbt108215793573
]Search in Google Scholar
[
77. Datta, S.K., Datta, K., Parkhi, V. et al. Golden rice: introgression, breeding, and field evaluation. Euphytica, 154, 2007, pp. 271–278.10.1007/s10681-006-9311-4
]Search in Google Scholar
[
78. Tang, G., Qin, J., Dolnikowski, G.G., Russell, R.M., Grusak, M.A. Golden rice is an effective source of vitamin A. Am. J. Clin. Nutr. 89, 2009, pp. 1776–1783.10.3945/ajcn.2008.27119268299419369372
]Search in Google Scholar
[
79. New Plant Variety Consultation: FDA (2018). https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=NewPlantVarietyConsultations. Accessed December 12th 2020.
]Search in Google Scholar
[
80. Provitamin A Biofortified Rice Event GR2E (Golden Rice): Health Canada (2018).https://www.canada.ca/en/health-canada/services/food-nutrition/genetically-modified-foods-other-novel-foods/approved-products/golden-rice-gr2e.html. Accessed 28th April 2021.
]Search in Google Scholar
[
81. Sautter, C., Poletti, S., Zhang, P., Gruissem, W. Biofortification of essential nutritional compounds and trace elements in rice and cassava. Proc. Nutr. Soc. 65, 2006, pp. 153–159.10.1079/PNS200648816672076
]Search in Google Scholar
[
82. Diretto G, Al-Babili S, Tavazza R. et al. Metabolic engineering of potato carotenoid content through tuber-specific overexpression of a bacterial mini-pathway. PLoS ONE 2, 2007, e350.10.1371/journal.pone.0000350183149317406674
]Search in Google Scholar
[
83. Díaz de la Garza, R.I., Gregory III, G.F., Hanson, A.D. Folate biofortification of tomato fruit. Proc. Natl. Acad. Sci. USA, 104, 2007, pp. 4218-4222.10.1073/pnas.0700409104181033217360503
]Search in Google Scholar
[
84. Narayanan, N., Beyene, G., Chauhan R.,D. et al. Biofortification of field-grown cassava by engineering expression of an iron transporter and ferritin. Nat. Biotechnol. 37, 2019, pp. 144-151.10.1038/s41587-018-0002-1678489530692693
]Search in Google Scholar
[
85. Connor, M.R., Atsumi, S. Synthetic biology guide biofuel production. BioMed Res. Int. 2010, 2010, 54169810.1155/2010/541698293519620827393
]Search in Google Scholar
[
86. Khatib, S.E., Yassine, N.A. Advances in Synthetic Biology and Metabolic Engineering in the Production of Biofuel. Int. J. Curr. Microbiol. App. Sci., 8, 2019, pp. 1762-1772.10.20546/ijcmas.2019.809.204
]Search in Google Scholar
[
87. Mortimer JC. Plant synthetic biology could drive a revolution in biofuels and medicine. Experimental Biology and Medicine. 244, 2019, pp,323-331.10.1177/1535370218793890643588530249124
]Search in Google Scholar
[
88. Verseux, C. et al. Sustainable life support on Mars – the potential roles of cyanobacteria. Int. J. Astrobiol. 15, 2016, pp. 65-92.10.1017/S147355041500021X
]Search in Google Scholar
[
89. Getting there and back. In: Human missions to Mars. Springer Praxis Books. Springer, Berlin, Heidelberg, 2008.
]Search in Google Scholar
[
90. Merino, N., Aronson, H.S., Bojanova, D.P. Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context. Front. Microbiol., 10, 2019, 780.10.3389/fmicb.2019.00780647634431037068
]Search in Google Scholar
[
91. Schröder, C., Burkhardt, C. & Antranikian, G. What we learn from extremophiles. ChemTexts 2020, 6, 8.10.1007/s40828-020-0103-6
]Search in Google Scholar
[
92. Ginsburg, I., Lingam, M., Loeb, A. Galactic panspermia. Astrophys. J. Lett., 868, 2018, L12.10.3847/2041-8213/aaef2d
]Search in Google Scholar
[
93. Wassmann, M., Moeller, R., Rabbow, E. et al. Survival of spores of the UV-resistant Bacillus subtilis strain MW01 after exposure to low-earth orbit and simulated Martian conditions: data from the space experiment ADAPT on EXPOSE-E. Astrobiology, 12, 2012, pp. 498-507.10.1089/ast.2011.077222680695
]Search in Google Scholar
[
94. Santomartino, R., Waajen, A.C., de Wit, W. No effect of microgravity and simulated Mars gravity on final bacterial cell concentrations on the International Space Station: applications to space bioproduction. Front. Microbiol. 11, 2020, 579156.10.3389/fmicb.2020.579156759170533154740
]Search in Google Scholar
[
95. Braddock, M. Limitations for colonisation and civilisation build and the potential for human enhancements. In: Human Enhancements for Space Missions. Space and Society. Szocik K. (eds) Springer, Cham. publishers 2020, pp. 71-93.10.1007/978-3-030-42036-9_5
]Search in Google Scholar
[
96. Ilardo M, Nielsen R. Human adaptation to extreme environmental conditions. Curr. Opin. Genet. Dev. 53, 2018, pp. 77-82.10.1016/j.gde.2018.07.003719376630077046
]Search in Google Scholar
[
97. Burtscher, M., Gatterer, H., Burtscher, J., Mairbäurl, H. Extreme terrestrial environments: life in thermal stress and hypoxia. A narrative review. Front. Physiol. 9, 2018, 572.10.3389/fphys.2018.00572596429529867589
]Search in Google Scholar
[
98. Clemente F.J. et al. A selective sweep on a deleterious mutation in CPT1A in Arctic populations. Am. J. Hum. Genet. 95, 2014, pp.584–589.10.1016/j.ajhg.2014.09.016422558225449608
]Search in Google Scholar
[
99. Fumagalli, M. et al.: Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science, 349, 2015, pp.1343–1347.10.1126/science.aab231926383953
]Search in Google Scholar
[
100. Key F.M. et al. Human local adaptation of the TRPM8 cold receptor along a latitudinal cline. PLoS Genet. 14, 2018, e1007298.10.1371/journal.pgen.1007298593370629723195
]Search in Google Scholar
[
101. Bigham A.W. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum. Genomics 4, 2009, pp.79–90.10.1186/1479-7364-4-2-79285738120038496
]Search in Google Scholar
[
102. Simonson, T.S, et al. Genetic evidence for high-altitude adaptation in Tibet. Science. 2010 329, 2010, pp. 72-75.
]Search in Google Scholar
[
103. Simonson, T.S., McClain, D.A., Jorde, L.B., Prchal, J.T. Genetic determinants of Tibetan high-altitude adaptation. Hum. Genet. 2012,131, pp.527-533.
]Search in Google Scholar
[
104. Hanaoka M. et al. Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas. PLoS One. 7, 2012, 50566.10.1371/journal.pone.0050566351561023227185
]Search in Google Scholar
[
105. MacInnis MJ, Wang P, Koehle MS, Rupert JL. The genetics of altitude tolerance: the evidence for inherited susceptibility to acute mountain sickness. J. Occup. Environ. Med. 53, 2011, pp.159-168.10.1097/JOM.0b013e318206b11221270658
]Search in Google Scholar
[
106. Peng Y, et al. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol. Biol. Evol. 28, 2011, pp, 1075-1081.10.1093/molbev/msq29021030426
]Search in Google Scholar
[
107. van Patot MC, Gassmann M. Hypoxia: adapting to high altitude by mutating EPAS-1, the gene encoding HIF-2α. High Alt. Med. Biol. 2011 12, 2011, pp.157-167.
]Search in Google Scholar
[
108. Zhou D. et al. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am. J. Hum. Genet. 93, 2013, pp. 452-62.10.1016/j.ajhg.2013.07.011376992523954164
]Search in Google Scholar
[
109. Valverde G. et al. A novel candidate region for genetic adaptation to high altitude in Andean populations. PLoS One 10, 2015, 0125444.10.1371/journal.pone.0125444442740725961286
]Search in Google Scholar
[
110. Angelin-Duclos, C. et al. Thyroid hormone T3 acting through the thyroid hormone α receptor is necessary for implementation of erythropoiesis in the neonatal spleen environment in the mouse. Development 132, 2005, pp. 925–934.10.1242/dev.0164815673575
]Search in Google Scholar
[
111. Ilardo, M.A. et al. Physiological and genetic adaptations to diving in sea nomads. Cell, 173, 2018, pp. 569–580.10.1016/j.cell.2018.03.05429677510
]Search in Google Scholar
[
112. Hickey, L.T., Hafeez, A.N., Robinson, H. et al. Breeding crops to feed 10 billion. Nat. Biotechnol. 37, 2019, pp. 744–754.10.1038/s41587-019-0152-931209375
]Search in Google Scholar
[
113. Voigt, C.A. Synthetic biology 2020-2030: six commercially-available products that are changing the world. Nat Commun. 11, 2020, article 6379.10.1038/s41467-020-20122-2773342033311504
]Search in Google Scholar
[
114. Brooks, S.M., Alper, H.S. Applications, challenges, and needs for employing synthetic biology beyond the lab. Nat. Commun. 2021, 12, 1390.
]Search in Google Scholar
[
115. Reynolds, J.L. Engineering biological diversity: the international governance of synthetic biology, gene drives and de-extinction for conservation. Curr. Op. Environ. Sust. 49, 2021, pp. 1-6.10.2139/ssrn.3688323
]Search in Google Scholar
[
116. Del Valle, I., Fulk, E.M., Kalvapalle, P. et al. Translating new synthetic biology advances for biosensing into the Earth and environmental sciences. Front. Microbiol. 11, 2021, article 618373.10.3389/fmicb.2020.618373790189633633695
]Search in Google Scholar
[
117. Douglas, T., Savulescu, J. Synthetic biology and the ethics of knowledge. J. Med. Ethics. 36, 2010, pp. 687-694.10.1136/jme.2010.038232304587920935316
]Search in Google Scholar
[
118. Wang, F., Zhang, W. Synthetic biology: recent progress, biosafety and biosecurity concerns, and possible solutions. J. Biosafety & Biosecurity 1, 2019, pp. 22-30.10.1016/j.jobb.2018.12.003
]Search in Google Scholar
[
119. Conde-Pueyo N, Vidiella B, Sardanyés J, et al. Synthetic biology for terraformation lessons from Mars, Earth, and the microbiome. Life 10, 2020:14.10.3390/life10020014717524232050455
]Search in Google Scholar