The frequency of EGFR gene mutations in a cohort of Romanian patients with non-small cell lung cancer and their association with PD-L1 expression level and ALK rearrangements

1 Cai Y, Wang Y, Sun J, Wang X, Xu Y, Sun C, Guo Y, Sun M, Ma K. Successful treatment of a patient with NSCLC carrying uncommon compound EGFR G719X and S768I mutations using osimertinib: A case report. J Int Med Res. 2020 Jun;48(6):300060520928793. DOI: 10.1177/0300060520928793 Search in Google Scholar

2 Peng L, Zhu L, Sun Y, Stebbing J, Selvaggi G, Zhang Y, Yu Z. Targeting ALK Rearrangements in NSCLC: Current State of the Art. Front Oncol. 2022 Apr 6;12:863461. DOI: 10.3389/fonc.2022.863461 Search in Google Scholar

3 Yin S, Chen Z, Chen D, Yan D. Strategies targeting PD-L1 expression and associated opportunities for cancer combination therapy. Theranostics. 2023 Mar 5;13(5):1520-1544. DOI: 10.7150/thno.80091 Search in Google Scholar

4 NCCN Guidelines Version 3.2023 Non-Small Cell Lung Cancer, 2023 Search in Google Scholar

5 DNA Sample Preparation Kit, Roche Diagnostics kit insert Search in Google Scholar

6 cobas® EGFR Mutation Test v2 insert Search in Google Scholar

7 SP263 (Ventana) kit insert Search in Google Scholar

8 OptiView DAB Amplification kit insert Search in Google Scholar

9 D5F3 Rabbit Monoclonal Antibody clone (Ventana) insert kit Search in Google Scholar

10 OptiView DAB IHC Detection Kit insert 16. Search in Google Scholar

11 https://www.who.int Search in Google Scholar

12 Hou J, Li H, Ma S, He Z, Yang S, Hao L, Zhou H, Zhang Z, Han J, Wang L, Wang Q. EGFR exon 20 insertion mutations in advanced non-small-cell lung cancer: current status and perspectives. Biomark Res. 2022 Apr 13;10(1):21. DOI: 10.1186/s40364-022-00372-6 Search in Google Scholar

13 Melosky B, Kambartel K, Häntschel M, Bennetts M, Nickens DJ, Brinkmann J, et al. Worldwide Prevalence of Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer: A Meta-Analysis. Mol Diagn Ther. 2022 Jan;26(1):7-18. DOI: 10.1007/s40291-021-00563-1 Search in Google Scholar

14 Lahmadi M, Beddar L, Rouibah AL, Boumegoura A, Boufendi H, Temim A, et al. Analysis of EGFR Mutation Status in Algerian Patients with Non-Small Cell Lung Cancer. Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1063-1068. DOI: 10.31557/APJCP.2021.22.4.1063 Search in Google Scholar

15 Mao L, Zhao W, Li X, Zhang S, Zhou C, Zhou D, et al. Mutation Spectrum of EGFR From 21,324 Chinese Patients with Non-Small Cell Lung Cancer (NSCLC) Successfully Tested by Multiple Methods in a CAP-Accredited Laboratory. Pathol Oncol Res. 2021 Apr 7; 27:602726. DOI: 10.3389/pore.2021.602726 Search in Google Scholar

16 Lee K, Jung HA, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ. Clinical Characteristics and Outcomes of Non-small Cell Lung Cancer Patients with HER2 Alterations in Korea. Cancer Res Treat. 2020 Jan;52(1):292-300. DOI: 10.4143/crt.2019.186 Search in Google Scholar

17 Mehta A, Vasudevan S. Rare epidermal growth factor receptor gene alterations in non-small cell lung cancer patients, tyrosine kinase inhibitor response and outcome analysis. Cancer Treat Res Commun. 2021;28:100398. DOI: 10.1016/j.ctarc.2021.100398 Search in Google Scholar

18 Kaler AK, Patel K, Patil H, Tiwarekar Y, Kulkarni B, Hastak M, et al. Mutational Analysis of EGFR Mutations in Non-Small Cell Lung Carcinoma-An Indian Perspective of 212 Patients. Int J Environ Res Public Health. 2022 Dec 31;20(1):758. DOI: 10.3390/ijerph20010758 Search in Google Scholar

19 Kim IA, Hur JY, Kim HJ, Lee SA, Hwang JJ, Kim WS, Lee KY. Targeted Next-Generation Sequencing Analysis Predicts the Recurrence in Resected Lung Adenocarcinoma Harboring EGFR Mutations. Cancers (Basel). 2021 Jul 20;13(14):3632 DOI: 10.3390/cancers13143632 Search in Google Scholar

20 Lee H, Han J, Choi YL. Real-World Analysis of the EGFR Mutation Test in Tissue and Plasma Samples from Non-Small Cell Lung Cancer. Diagnostics (Basel). 2021 Sep 17;11(9):1695. DOI: 10.3390/diagnostics11091695 Search in Google Scholar

21 Gu L, Huang H, Xu Z, Niu X, Li Z, Xia L, Yu Y, Lu S. Landscape and Predictive Significance of the Structural Classification of EGFR Mutations in Chinese NSCLCs: A Real-World Study. J Clin Med. 2022 Dec 28;12(1):236. DOI: 10.3390/jcm12010236 Search in Google Scholar

22 Ko HW, Shie SS, Wang CW, Chiu CT, Wang CL, Yang TY, et al. Association of smoking status with non-small cell lung cancer patients harboring uncommon epidermal growth factor receptor mutation. Front Immunol. 2022 Oct 20;13:1011092. DOI: 10.3389/fimmu.2022.1011092 Search in Google Scholar

23 Yu X, Si J, Wei J, Wang Y, Sun Y, Jin J, Zhang X, Ma T, Song Z. The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study. Cancer Med. 2023 Mar;12(5):5630-5638. DOI: 10.1002/cam4.5413 Search in Google Scholar

24 Chang JW, Huang CY, Fang YF, Chang CF, Yang CT, Kuo CS, Hsu PC, Wu CE. Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer harboring uncommon EGFR mutations: Real-world data from Taiwan. Thorac Cancer. 2023 Jan;14(1):12-23. DOI: 10.1111/1759-7714.14537 Search in Google Scholar

25 Nakra T, Mehta A, Bal A, Nambirajan A, Mishra D, Midha D, et al. Epidermal growth factor receptor mutation status in pulmonary adenocarcinoma: Multi-institutional data discussion at national conference of “Lung Cancer Management in Indian context”. Curr Probl Cancer. 2020 Jun;44(3):100561. DOI: 10.1016/j. currproblcancer.2020.100561 Search in Google Scholar

26 Masuda K, Horinouchi H, Tanaka M, Higashiyama R, Shinno Y, Sato J, Matsumoto Y, Okuma Y, Yoshida T, Goto Y, Yamamoto N, Ohe Y. Efficacy of anti-PD-1 antibodies in NSCLC patients with an EGFR mutation and high PD-L1 expression. J Cancer Res Clin Oncol. 2021 Jan;147(1):245-251. DOI: 10.1007/s00432-020-03329-0 Search in Google Scholar

27 Imyanitov EN, Iyevleva AG, Levchenko EV. Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives. Crit rev oncol hematol. 2021;157:103194. DOI: 10.1016/j.critrevonc.2020.103194 Search in Google Scholar

28 Dalurzo ML, Avilés-Salas A, Soares FA, Hou Y, Li Y, Stroganova A, et al. Testing for EGFR Mutations and ALK Rearrangements in Advanced Non-Small-Cell Lung Cancer: Considerations for Countries in Emerging Markets. Onco Targets Ther. 2021 Sep 1;14:4671-4692. DOI: 10.2147/OTT.S313669 Search in Google Scholar