<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec>
<h3>Introduction</h3>
<p>In this study, we seek to determine the association between the polymorphism of the <italic>ADIPOQ (rs1501299)</italic> gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.</p>
</sec>
<sec>
<h3>Methods</h3>
<p>The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.</p>
</sec>
<sec>
<h3>Results</h3>
<p>Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).</p>
</sec>
<sec>
<h3>Conclusion</h3>
<p>Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.</p>
</sec>
</abstract>

Introduction
In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.


Methods
The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.


Results
Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).


Conclusion
Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.

Association between adiponectin and <italic>ADIPOQ (rs 1501299)</italic> gene polymorphism in gestational diabetes mellitus patients

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution 4.0 International License.

Association between adiponectin and  gene polymorphism in gestational diabetes mellitus patients

Introduction
In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational...

Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

Article Category: Research Article

Pubblicato online: 04 mag 2023

Pagine: 119 - 124

Ricevuto: 12 gen 2023

Accettato: 07 mar 2023

DOI: https://doi.org/10.2478/rrlm-2023-0010

Parole chiave
gestational diabetes mellitus, adiponectin, polymorphism

© 2023 Suat Cakina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

Article Category: Research Article

Pubblicato online: 04 mag 2023

Pagine: 119 - 124

Ricevuto: 12 gen 2023

Accettato: 07 mar 2023

DOI: https://doi.org/10.2478/rrlm-2023-0010

Parole chiavegestational diabetes mellitus, adiponectin, polymorphism

© 2023 Suat Cakina et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Parole chiave
gestational diabetes mellitus, adiponectin, polymorphism