<abstract xmlns="http://www.w3.org/1999/xhtml"><p>MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.</p></abstract>

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular functions. A growing number of studies suggest the abnormal expression of microRNAs in different types of cancer cells. MiRNA-124 is a microRNA that is down-regulated in many types of cancer cells, including bladder cancer. Our objective is to provide a review of the key publications that studied the effect of miR-124 on bladder cancer. This review focus on the targets and different pathways of miR-124 that were identified in various studies and differences between their expressions in normal urothelium and tumor tissues. We also include data regarding urinary methylations levels of miR-124 and their role in bladder cancer diagnosis and prognosis. Subsequently, we establish future perspectives of miR-124 research and its promising role in bladder cancer.

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

“Carol Davila” University of Medicine and Pharmacy

Department for Immunogenetics and Virology

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Role of MiR-124 in Bladder Cancer \u2013 A Review of the Literature"}

MicroRNAs (miRNAs) are a group of non-coding RNA molecules that have an important role in modulating the expression of genes involved in regulating cellular...

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Pubblicato online: 29 gen 2021

Pagine: 9 - 18

Ricevuto: 30 giu 2020

Accettato: 19 nov 2020

DOI: https://doi.org/10.2478/rrlm-2021-0001

Parole chiave
bladder cancer, miR-124, microRNA, miR-124 target, miRNAs

© 2021 Costin Petcu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Role of MiR-124 in Bladder Cancer – A Review of the Literature

Pubblicato online: 29 gen 2021

Pagine: 9 - 18

Ricevuto: 30 giu 2020

Accettato: 19 nov 2020

DOI: https://doi.org/10.2478/rrlm-2021-0001

Parole chiavebladder cancer, miR-124, microRNA, miR-124 target, miRNAs

© 2021 Costin Petcu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
bladder cancer, miR-124, microRNA, miR-124 target, miRNAs