<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Objective</bold>: Microsatellite instability (MSI) in gastric cancer contributes to genetic complexities of gastric cancer. In the current study, we employed a panel of mononucleotide and dinucleotide markers to detect MSI in 99 gastric cancer patients and 91 chronic gastritis patients and further analyzed the association of MSI with clinicopathologic variables of the study patients.<bold>Methods</bold>: We retrospectively analyzed the clinicopathologic data of primary gastric cancer patients and chronic gastritis patients. MSI was analyzed using five microsatellite markers, including D2S12, D5S346, D17S799, BAT26, and D18S34. MSI was defined as either a band shift or the appearance of a novel band in DNA. Multivariate logistic regression analysis was used to predict risk of MSI.<bold>Results</bold>: Seventeen (17.2%) gastric cancer patients and 7 (7.7%) chronic gastritis patients were positive for MSI (P=0.012). Multivariate analysis further showed that gastric cancer was associated with a significantly higher likelihood for MSI versus gastritis (OR 3.73; 95% CI 1.19, 11.72; P=0.024) while age, drinking or smoking was not associated with increased MSI.<bold>Conclusion</bold>: Gastric cancer is associated with a high rate of MSI. MSI should be further explored in future studies with a larger sample size for its role in gastric cancer development and as a predictive biomarker.</abstract>

Objective: Microsatellite instability (MSI) in gastric cancer contributes to genetic complexities of gastric cancer. In the current study, we employed a panel of mononucleotide and dinucleotide markers to detect MSI in 99 gastric cancer patients and 91 chronic gastritis patients and further analyzed the association of MSI with clinicopathologic variables of the study patients.Methods: We retrospectively analyzed the clinicopathologic data of primary gastric cancer patients and chronic gastritis patients. MSI was analyzed using five microsatellite markers, including D2S12, D5S346, D17S799, BAT26, and D18S34. MSI was defined as either a band shift or the appearance of a novel band in DNA. Multivariate logistic regression analysis was used to predict risk of MSI.Results: Seventeen (17.2%) gastric cancer patients and 7 (7.7%) chronic gastritis patients were positive for MSI (P=0.012). Multivariate analysis further showed that gastric cancer was associated with a significantly higher likelihood for MSI versus gastritis (OR 3.73; 95% CI 1.19, 11.72; P=0.024) while age, drinking or smoking was not associated with increased MSI.Conclusion: Gastric cancer is associated with a high rate of MSI. MSI should be further explored in future studies with a larger sample size for its role in gastric cancer development and as a predictive biomarker.

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study

Second Hospital of Hebei Medical University

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Objective: Microsatellite instability (MSI) in gastric cancer contributes to genetic complexities of gastric cancer. In the current study, we employed a panel...

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study

Pubblicato online: 07 feb 2020

Pagine: 57 - 65

Ricevuto: 22 apr 2019

Accettato: 13 dic 2019

DOI: https://doi.org/10.2478/rrlm-2020-0006

Parole chiave
microsatellite instability (MSI), gastric cancer, gastritis, predictive biomarker, clinicopathologic variables

© 2020 Li Xing et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study

Pubblicato online: 07 feb 2020

Pagine: 57 - 65

Ricevuto: 22 apr 2019

Accettato: 13 dic 2019

DOI: https://doi.org/10.2478/rrlm-2020-0006

Parole chiavemicrosatellite instability (MSI), gastric cancer, gastritis, predictive biomarker, clinicopathologic variables

© 2020 Li Xing et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
microsatellite instability (MSI), gastric cancer, gastritis, predictive biomarker, clinicopathologic variables