<abstract xmlns="http://www.w3.org/1999/xhtml">Introduction: Myxofibrosarcoma is a rare subtype of soft tissue sarcoma with a locally infiltrative behavior and ability to determine distant metastases.Materials and methods: We presented two myxofibrosarcoma cases who benefited from segmental or radical resection.Management and outcome: In the case of the 80-year-old woman, with grade 3 myxofibrosarcoma, we practiced radical surgery with scapulohumeral disarticulation followed by adjuvant radiotherapy.The therapeutic option for the 77-year-old man with grade 2 myxofibrosarcoma was segmental resection followed by adjuvant radiotherapy. After three months, the patient was in a good clinical condition with no sign of local recurrence, but with the presence of pulmonary metastases for the patient who benefited of segmental resection.Discussion: The radical resection had better short-term results, with no local or distant metastases at three months after surgery, although the tumor had a higher grade (G3), compared to segmental resection practiced for a lower grade tumor (G2), in which case the patient developed pulmonary metastasis at three months follow up.Conclusion: Myxofibrosarcoma represents a challenging situation regarding the management due to its unpredictive clinical course. Our cases raised the following question: should we consider treating it more aggressively in order to obtain good local control and reduce the risk of metastasis?</abstract>

Introduction: Myxofibrosarcoma is a rare subtype of soft tissue sarcoma with a locally infiltrative behavior and ability to determine distant metastases.Materials and methods: We presented two myxofibrosarcoma cases who benefited from segmental or radical resection.Management and outcome: In the case of the 80-year-old woman, with grade 3 myxofibrosarcoma, we practiced radical surgery with scapulohumeral disarticulation followed by adjuvant radiotherapy.The therapeutic option for the 77-year-old man with grade 2 myxofibrosarcoma was segmental resection followed by adjuvant radiotherapy. After three months, the patient was in a good clinical condition with no sign of local recurrence, but with the presence of pulmonary metastases for the patient who benefited of segmental resection.Discussion: The radical resection had better short-term results, with no local or distant metastases at three months after surgery, although the tumor had a higher grade (G3), compared to segmental resection practiced for a lower grade tumor (G2), in which case the patient developed pulmonary metastasis at three months follow up.Conclusion: Myxofibrosarcoma represents a challenging situation regarding the management due to its unpredictive clinical course. Our cases raised the following question: should we consider treating it more aggressively in order to obtain good local control and reduce the risk of metastasis?

Short-term comparative results of segmental resection versus radical resection in two patients with myxofibrosarcoma of the limbs - case series

“Carol Davila” University of Medicine and Pharmacy

Romanian Journal of Orthopaedic Surgery and Traumatology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: Myxofibrosarcoma is a rare subtype of soft tissue sarcoma with a locally infiltrative behavior and ability to determine distant...

Short-term comparative results of segmental resection versus radical resection in two patients with myxofibrosarcoma of the limbs - case series

Pubblicato online: 03 ago 2020

Pagine: 9 - 14

Accettato: 23 giu 2020

DOI: https://doi.org/10.2478/rojost-2020-0003

Parole chiave
myxofibrosarcoma, segmental resection, radical resection, treatment, case report

© 2020 Sergiu-Andrei Iordache et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Short-term comparative results of segmental resection versus radical resection in two patients with myxofibrosarcoma of the limbs - case series

Pubblicato online: 03 ago 2020

Pagine: 9 - 14

Accettato: 23 giu 2020

DOI: https://doi.org/10.2478/rojost-2020-0003

Parole chiavemyxofibrosarcoma, segmental resection, radical resection, treatment, case report

© 2020 Sergiu-Andrei Iordache et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
myxofibrosarcoma, segmental resection, radical resection, treatment, case report