<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Wegener’s granulomatosis (Granulomatosis with Polyangiitis) is an autoimmune granulomatous disorder of unknown etiology. The basic pathology is necrotizing granulomatous inflammation with necrotizing vasculitis involving medium-sized blood vessels. The typical triad of involvement of the upper and lower respiratory tracts and the kidneys is observed in varying proportions in individual patients. The sinonasal involvement is observed in the majority of patients and it can be involved in isolation in up to a quarter of affected individuals. The sinonasal changes involve both the soft tissue and bony architecture, with refractory chronic sinusitis associated with erosion of the cartilaginous and bony skeleton and may lead to saddle nose and other facial deformities in advanced cases. The radiology has a contributory role as diagnostic and diseases monitoring aid.</p><p>The various radiological findings associated with the disease (bone erosion with osteoneogenesis) have been mentioned in the literature. We present the progression of a radiological abnormality in a patient with a localized form of Wegener’s Granulomatosis and highlight some peculiar appearances observed on radiology in the patient.</p></abstract>

Wegener’s granulomatosis (Granulomatosis with Polyangiitis) is an autoimmune granulomatous disorder of unknown etiology. The basic pathology is necrotizing granulomatous inflammation with necrotizing vasculitis involving medium-sized blood vessels. The typical triad of involvement of the upper and lower respiratory tracts and the kidneys is observed in varying proportions in individual patients. The sinonasal involvement is observed in the majority of patients and it can be involved in isolation in up to a quarter of affected individuals. The sinonasal changes involve both the soft tissue and bony architecture, with refractory chronic sinusitis associated with erosion of the cartilaginous and bony skeleton and may lead to saddle nose and other facial deformities in advanced cases. The radiology has a contributory role as diagnostic and diseases monitoring aid.The various radiological findings associated with the disease (bone erosion with osteoneogenesis) have been mentioned in the literature. We present the progression of a radiological abnormality in a patient with a localized form of Wegener’s Granulomatosis and highlight some peculiar appearances observed on radiology in the patient.

Evolution of sinonasal radiological findings in a case of granulomatosis with polyangiitis

Department of Otolaryngology and Head and Neck Surgery

Division of Radiology and Nuclear Medicine

Romanian Journal of Rhinology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Wegener’s granulomatosis (Granulomatosis with Polyangiitis) is an autoimmune granulomatous disorder of unknown etiology. The basic pathology is necrotizing...

Evolution of sinonasal radiological findings in a case of granulomatosis with polyangiitis

Pubblicato online: 07 mar 2019

Pagine: 43 - 48

Ricevuto: 02 nov 2018

Accettato: 10 dic 2018

DOI: https://doi.org/10.2478/rjr-2019-0006

Parole chiave
Wegener’s Granulomatosis, chronic rhinosinusitis, radiology, osteoneogenesis

© 2019 Aru Chhabra Handa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Evolution of sinonasal radiological findings in a case of granulomatosis with polyangiitis

Pubblicato online: 07 mar 2019

Pagine: 43 - 48

Ricevuto: 02 nov 2018

Accettato: 10 dic 2018

DOI: https://doi.org/10.2478/rjr-2019-0006

Parole chiaveWegener’s Granulomatosis, chronic rhinosinusitis, radiology, osteoneogenesis

© 2019 Aru Chhabra Handa et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Wegener’s Granulomatosis, chronic rhinosinusitis, radiology, osteoneogenesis