<abstract xmlns="http://www.w3.org/1999/xhtml">

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<h3>Introduction:</h3> <p>The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represented a disruptive pathology that emerged in late 2019 with profound implications ranging from individual health to health systems and world economy. Our study aimed to evaluate clinical, biochemical and computerized tomography (CT) parameters values in determining the severity of pulmonary embolism (PE) associated with COVID-19.</p>
</sec>
<sec>
<h3>Methods</h3><p>We performed an observational cohort study evaluating demographic, clinical, biochemical, coagulation markers, as well as CT imaging parameters.</p>
</sec>
<sec><h3>Results</h3>
<p>In our study on 186 patients with COVID-19, we found that 31 patients (16,66%) had pulmonary embolism. Significant correlations for the patients with PE were detected in C-reactive protein, lactate dehydrogenase, serum ferritin, IL-6, serum myoglobin, NT-proBNP, D-dimers, serum proteins, transaminases as well as white cell blood counts. Patients with pulmonary embolism had a more severe lung involvement, with thrombi distribution mainly involving the lower lobes.</p>
</sec>
<sec><h3>Conclusion</h3>
<p>Early identification of PE is an important step for timely and efficient treatment in the intensive care management of COVID-19 patients. Our study showed that high plasmatic values of lactate dehydrogenase, ferritin, IL-6, white blood cells and D-dimers and low proteins serum levels are strongly linked with COVID-19-associated pulmonary embolism.</p>
</sec>
</abstract>

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represented a disruptive pathology that emerged in late 2019 with profound implications ranging from individual health to health systems and world economy. Our study aimed to evaluate clinical, biochemical and computerized tomography (CT) parameters values in determining the severity of pulmonary embolism (PE) associated with COVID-19.


MethodsWe performed an observational cohort study evaluating demographic, clinical, biochemical, coagulation markers, as well as CT imaging parameters.

Results
In our study on 186 patients with COVID-19, we found that 31 patients (16,66%) had pulmonary embolism. Significant correlations for the patients with PE were detected in C-reactive protein, lactate dehydrogenase, serum ferritin, IL-6, serum myoglobin, NT-proBNP, D-dimers, serum proteins, transaminases as well as white cell blood counts. Patients with pulmonary embolism had a more severe lung involvement, with thrombi distribution mainly involving the lower lobes.

Conclusion
Early identification of PE is an important step for timely and efficient treatment in the intensive care management of COVID-19 patients. Our study showed that high plasmatic values of lactate dehydrogenase, ferritin, IL-6, white blood cells and D-dimers and low proteins serum levels are strongly linked with COVID-19-associated pulmonary embolism.

COVID-19 associated pulmonary embolism: clinical, biochemical and CT imaging findings

University of Medicine and Pharmacy Carol Davila

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection represented a disruptive pathology that emerged in late 2019 with...

COVID-19 associated pulmonary embolism: clinical, biochemical and CT imaging findings

Pubblicato online: 19 apr 2024

Pagine: -

Ricevuto: 20 gen 2024

DOI: https://doi.org/10.2478/rjim-2024-0017

Parole chiave
pulmonary embolism, thrombosis, thromboinflammation, COVID-19, SARS-CoV-2 infection, risk factors

© 2024 Eduard Dumea et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

COVID-19 associated pulmonary embolism: clinical, biochemical and CT imaging findings

Pubblicato online: 19 apr 2024

Pagine: -

Ricevuto: 20 gen 2024

DOI: https://doi.org/10.2478/rjim-2024-0017

Parole chiavepulmonary embolism, thrombosis, thromboinflammation, COVID-19, SARS-CoV-2 infection, risk factors

© 2024 Eduard Dumea et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
pulmonary embolism, thrombosis, thromboinflammation, COVID-19, SARS-CoV-2 infection, risk factors