<abstract xmlns="http://www.w3.org/1999/xhtml">

Perioperative acid-base disturbance could be informative regarding the possible slow graft function (SGF) or delayed graft function (DGF) development. There is a lack of data regarding the relationship between perioperative acid-base parameters and graft dysfunction in kidney transplant (KT) recipients. We aim to determine the incidence of graft dysfunction types and the association between them and acid-base parameters.
We performed a prospective, cohort study on 54 adults, KT recipients, between 1st of January 2019 and 31st of December 2019. Graft function was defined and classified in three categories: immediate graft function (IGF) (serum creatinine &lt; 3 mg/dL at day 5 after KT), SGF (serum creatinine ≥ 3mg/dL at day 5 or ≥ 2.5mg dL at day 7 after KT) and DGF (the need for at least one dialysis treatment in the first week after kidney transplantation). Among the 54 KT recipients, the incidence of SGF and DGF was 13% and 11.1%, respectively. SGF was significantly associated with lower intraoperative pH (7.26± 0.05 vs 7.35± 0.06, p= 0.004), preoperative and intraoperative base excess (BE) [−7.0 (−10.0 ߝ −6.0) vs −3.4 (−7.8 ߝ − 2.1) mmol/L, p= 0.04 and −10.3 (−11.0 ߝ −9.1) vs −4.0 (−6.3 ߝ − 3.0) mmol/L, p= 0.002, respectively] and serum bicarbonate (HCO3−) (16.0± 2.7 vs 19.3± 3.4 mmol/L, p= 0.01 and 14.1± 1.9 vs 18.8± 3.2 mmol/L, p= 0.002 respectively), compared to IGF. DGF was significantly associated with lower intraoperative values of pH (7.27± 0.05 vs 7.35± 0.06, p= 0.003), BE [−7.1 (−10.9 ߝ −6.1) vs −4.0 (−6.3 ߝ − 3.0) mmol/L, p= 0.02] and HCO3− (15.9± 2.4 vs 18.8± 3.2 mmol/L, p=0.02) compared to IGF. No differences were observed between SGF and DGF patients in any of the perioperative acid-base parameters.
In conclusion we found that kidney graft dysfunction types are associated with perioperative acid-base parameters and perioperative metabolic acidosis could provide important information to predict SGF or DGF occurrence.
</abstract>

Perioperative acid-base disturbance could be informative regarding the possible slow graft function (SGF) or delayed graft function (DGF) development. There is a lack of data regarding the relationship between perioperative acid-base parameters and graft dysfunction in kidney transplant (KT) recipients. We aim to determine the incidence of graft dysfunction types and the association between them and acid-base parameters.
We performed a prospective, cohort study on 54 adults, KT recipients, between 1st of January 2019 and 31st of December 2019. Graft function was defined and classified in three categories: immediate graft function (IGF) (serum creatinine < 3 mg/dL at day 5 after KT), SGF (serum creatinine ≥ 3mg/dL at day 5 or ≥ 2.5mg dL at day 7 after KT) and DGF (the need for at least one dialysis treatment in the first week after kidney transplantation). Among the 54 KT recipients, the incidence of SGF and DGF was 13% and 11.1%, respectively. SGF was significantly associated with lower intraoperative pH (7.26± 0.05 vs 7.35± 0.06, p= 0.004), preoperative and intraoperative base excess (BE) [−7.0 (−10.0 ߝ −6.0) vs −3.4 (−7.8 ߝ − 2.1) mmol/L, p= 0.04 and −10.3 (−11.0 ߝ −9.1) vs −4.0 (−6.3 ߝ − 3.0) mmol/L, p= 0.002, respectively] and serum bicarbonate (HCO3−) (16.0± 2.7 vs 19.3± 3.4 mmol/L, p= 0.01 and 14.1± 1.9 vs 18.8± 3.2 mmol/L, p= 0.002 respectively), compared to IGF. DGF was significantly associated with lower intraoperative values of pH (7.27± 0.05 vs 7.35± 0.06, p= 0.003), BE [−7.1 (−10.9 ߝ −6.1) vs −4.0 (−6.3 ߝ − 3.0) mmol/L, p= 0.02] and HCO3− (15.9± 2.4 vs 18.8± 3.2 mmol/L, p=0.02) compared to IGF. No differences were observed between SGF and DGF patients in any of the perioperative acid-base parameters.
In conclusion we found that kidney graft dysfunction types are associated with perioperative acid-base parameters and perioperative metabolic acidosis could provide important information to predict SGF or DGF occurrence.

Association between peri-transplant acid-base parameters and graft dysfunction types in kidney transplantation

“Carol Davila” University of Medicine and Pharmacy

Craiova University of Medicine and Pharmacy

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Perioperative acid-base disturbance could be informative regarding the possible slow graft function (SGF) or delayed graft function (DGF) development. There is...

Association between peri-transplant acid-base parameters and graft dysfunction types in kidney transplantation

Pubblicato online: 28 dic 2023

Pagine: 178 - 183

Ricevuto: 11 ott 2023

DOI: https://doi.org/10.2478/rjim-2023-0037

Parole chiave
kidney transplant, acid-base, pH, graft function, slow, delayed, bicarbonate, base excess

© 2023 Teodor Căluşi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Association between peri-transplant acid-base parameters and graft dysfunction types in kidney transplantation

Pubblicato online: 28 dic 2023

Pagine: 178 - 183

Ricevuto: 11 ott 2023

DOI: https://doi.org/10.2478/rjim-2023-0037

Parole chiavekidney transplant, acid-base, pH, graft function, slow, delayed, bicarbonate, base excess

© 2023 Teodor Căluşi et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Parole chiave
kidney transplant, acid-base, pH, graft function, slow, delayed, bicarbonate, base excess