<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay. The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and muscle inexcitability. Sepsis induced myopathy is characterized by several electrophysiological and histopathological abnormalities of the muscle, also has clinical consequences such as flaccid weakness and failure to wean from ventilator. In order to reach definite diagnosis, clinical assessment, electrophysiological studies and muscle biopsy must be performed, which can be challenging in daily practice. Ultrasonography as a screening tool can be a promising alternative, especially in the ICU setting. Sepsis and mechanical ventilation have additive effects leading to diaphragm dysfunction thus complicating the patient’s clinical course and recovery. Here, we summarize the effects of the septic syndrome on the muscle tissue based on the existing literature.</p>
</abstract>

Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay. The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and muscle inexcitability. Sepsis induced myopathy is characterized by several electrophysiological and histopathological abnormalities of the muscle, also has clinical consequences such as flaccid weakness and failure to wean from ventilator. In order to reach definite diagnosis, clinical assessment, electrophysiological studies and muscle biopsy must be performed, which can be challenging in daily practice. Ultrasonography as a screening tool can be a promising alternative, especially in the ICU setting. Sepsis and mechanical ventilation have additive effects leading to diaphragm dysfunction thus complicating the patient’s clinical course and recovery. Here, we summarize the effects of the septic syndrome on the muscle tissue based on the existing literature.

Sepsis and the muscle tissue. A narrative review

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Sepsis and the muscle tissue. A narrative review"}

Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity...

Sepsis and the muscle tissue. A narrative review

Pubblicato online: 26 ago 2021

Pagine: 218 - 226

Ricevuto: 05 dic 2020

DOI: https://doi.org/10.2478/rjim-2021-0005

Parole chiave
sepsis, muscle tissue, myopathy, intensive care unit, diaphragm, critical illness

© 2021 Eleousa Oikonomou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Sepsis and the muscle tissue. A narrative review

Pubblicato online: 26 ago 2021

Pagine: 218 - 226

Ricevuto: 05 dic 2020

DOI: https://doi.org/10.2478/rjim-2021-0005

Parole chiavesepsis, muscle tissue, myopathy, intensive care unit, diaphragm, critical illness

© 2021 Eleousa Oikonomou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
sepsis, muscle tissue, myopathy, intensive care unit, diaphragm, critical illness