<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Background.</bold> Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition and electrolyte deficiencies. Although many autoimmune diseases are seen with increased frequency in CVID patients, primary hypoparathyroidism is extremely rare.<bold>Case presentation.</bold> A 50-year-old man with CVID presented with diarrhea. The patient had complaints for 2 years and was cachectic. He had severe electrolyte and vitamin deficiencies that did not respond to oral treatment. The diarrhea causes such as celiac, inflammatory bowel diseases, and gastrointestinal infections were excluded and the endoscopy showed enteropathic changes in the duodenum and colon. Concomitant hypoparathyroidism was also detected in the patient with hypocalcemia despite adequate replacement.<bold>Conclusion.</bold> Parenteral therapy should be considered in the management of CVID enteropathy cases that do not respond to oral replacement. Although very rare, hypoparathyroidism should be considered in the differential diagnosis of CVID patients with treatment-resistant hypocalcemia.</abstract>

Background. Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and gastrointestinal infections, and may cause enteropathy in some patients, which leads to severe malnutrition and electrolyte deficiencies. Although many autoimmune diseases are seen with increased frequency in CVID patients, primary hypoparathyroidism is extremely rare.Case presentation. A 50-year-old man with CVID presented with diarrhea. The patient had complaints for 2 years and was cachectic. He had severe electrolyte and vitamin deficiencies that did not respond to oral treatment. The diarrhea causes such as celiac, inflammatory bowel diseases, and gastrointestinal infections were excluded and the endoscopy showed enteropathic changes in the duodenum and colon. Concomitant hypoparathyroidism was also detected in the patient with hypocalcemia despite adequate replacement.Conclusion. Parenteral therapy should be considered in the management of CVID enteropathy cases that do not respond to oral replacement. Although very rare, hypoparathyroidism should be considered in the differential diagnosis of CVID patients with treatment-resistant hypocalcemia.

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Department of Endocrinology and Metabolism Disorders

Department of Infectious Diseases and Clinical Microbiology

Department of Immunology and Allergy Diseases

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background. Common variable immunodeficiency (CVID) is a rare disease characterized by humoral immunodeficiency, often causing sinopulmonary and...

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Pubblicato online: 05 mar 2021

Pagine: 83 - 87

Ricevuto: 03 ago 2020

DOI: https://doi.org/10.2478/rjim-2020-0030

Parole chiave
hypoparathyroidism, electrolyte deficiency, CVID, enteropathy, colitis

© 2021 Rashad Ismayilov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Primary hypoparathyroidism in a patient with common variable immunodeficiency associated enteropathy

Pubblicato online: 05 mar 2021

Pagine: 83 - 87

Ricevuto: 03 ago 2020

DOI: https://doi.org/10.2478/rjim-2020-0030

Parole chiavehypoparathyroidism, electrolyte deficiency, CVID, enteropathy, colitis

© 2021 Rashad Ismayilov et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
hypoparathyroidism, electrolyte deficiency, CVID, enteropathy, colitis