<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Thrombotic Thrombocytopenic Purpura (TTP) is a thrombotic microangiopathy syndrome resulting from decrease or absence of “a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13” (ADAMTS13). TTP has been characterized by the classical pentad of thrombocytopenia, hemolysis, fever, renal injury and neurological deficits, yet the patient may present with any atypical symptom related to microthrombi formation in the microcirculation. Here we present a rare case of a young patient with retrosternal chest pain and myocardial injury as the first manifestation of TTP.</p></abstract>

Thrombotic Thrombocytopenic Purpura (TTP) is a thrombotic microangiopathy syndrome resulting from decrease or absence of “a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13” (ADAMTS13). TTP has been characterized by the classical pentad of thrombocytopenia, hemolysis, fever, renal injury and neurological deficits, yet the patient may present with any atypical symptom related to microthrombi formation in the microcirculation. Here we present a rare case of a young patient with retrosternal chest pain and myocardial injury as the first manifestation of TTP.

Chest pain with increased troponin level; not always a cardiology issue

National and Kapodistrian University of Athens School of Medicine

Hematology Unit, 3rd Department of Internal Medicine

Department of Cardiology, General Hospital of Karditsa

Hematology Unit, General Hospital of Trikala

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Chest pain with increased troponin level; not always a cardiology issue"}

Thrombotic Thrombocytopenic Purpura (TTP) is a thrombotic microangiopathy syndrome resulting from decrease or absence of “a disintegrin and metalloproteinase...

Chest pain with increased troponin level; not always a cardiology issue

Pubblicato online: 20 giu 2019

Pagine: 201 - 204

Ricevuto: 02 set 2018

DOI: https://doi.org/10.2478/rjim-2018-0037

Parole chiave
Thrombotic Thrombocytopenic Purpura, Myocardial Injury, ADAMTS13, Microvascular Hemolysis

© 2019 Stamatis S. Papadatos et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Chest pain with increased troponin level; not always a cardiology issue

Pubblicato online: 20 giu 2019

Pagine: 201 - 204

Ricevuto: 02 set 2018

DOI: https://doi.org/10.2478/rjim-2018-0037

Parole chiaveThrombotic Thrombocytopenic Purpura, Myocardial Injury, ADAMTS13, Microvascular Hemolysis

© 2019 Stamatis S. Papadatos et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
Thrombotic Thrombocytopenic Purpura, Myocardial Injury, ADAMTS13, Microvascular Hemolysis