Downregulation of tumor-suppressor gene LHX6 in cancer: a systematic review

1. GRIGORIOU M., TUCKER AS., SHARPE PT., PACHNIS V. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998; 125(11):2063-2074.10.1242/dev.125.11.20639570771Search in Google Scholar

2. ESTÉCIO MRH., YOUSSEF EM., RAHAL P., FUKUYAMA EE., GÓIS-FILHO JF., MANIGLIA JV., et al. LHX6 is a sensitive methylation marker in head and neck carcinomas. Oncogene. 2006; 25:5018-5026.10.1038/sj.onc.120950916732332Search in Google Scholar

3. PERRENOUD Q., GEOFFROY H., GAUTHIER B., RANCILLAC A., ALFONSI F., KESSARIS N., et al. Characterization of type I and type II nNOS-Expressing interneurons in the barrel cortex of mouse. Front Neural Circuits. 2012; 6:36.10.3389/fncir.2012.00036338649222754499Search in Google Scholar

4. NEVES G., SHAH MM., LIODIS P., ACHIMASTOU A., DENAXA M., ROALFE G., et al. The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cereb Cortex. 2013; 23(8):1811–1823.10.1093/cercor/bhs159369836522710612Search in Google Scholar

5. PASCHOU P., STYLIANOPOULOU E., KARAGIANNIDIS I., RIZZO R., TARNOK Z., WOLANCZYK T., et al. Evaluation of the LIM homeobox genes LHX6 and LHX8 as candidates for Tourette syndrome. Genes Brain Behav. 2012; 11(4):444-451.10.1111/j.1601-183X.2012.00778.x22435649Search in Google Scholar

6. ALIFRAGIS P., LIAPI A., PARNAVELAS JG. Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype. J Neurosci. 2004; 24(24):5643–5648.10.1523/JNEUROSCI.1245-04.2004672933715201337Search in Google Scholar

7. FLANDIN P., ZHAO Y., VOGT D., JEONG J., LONG J., POTTER G., et al. Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron. 2011; 70(5):939–950.10.1016/j.neuron.2011.04.020315340921658586Search in Google Scholar

8. SUSSEL L., MARIN O., KIMURA S., RUBENSTEIN JL. Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999; 126(15):3359–3370.10.1242/dev.126.15.335910393115Search in Google Scholar

9. SANDBERG M., FLANDIN P., SILBERBERG S., SU-FEHER L., PRICE JD., HU JS., et al. Transcriptional networks controlled by NKX2-1 in the development of forebrain GABAergic neurons. Neuron. 2016; 91(6):1260–1275.10.1016/j.neuron.2016.08.020531985427657450Search in Google Scholar

10. KIM TG., YAO R., MONNELL T., CHO JH., VASUDEVAN A., KOH A., et al. Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation. Stem Cells. 2014; 32(7):1789–1804.10.1002/stem.1704414772024648391Search in Google Scholar

11. ZHAO Y., FLANDIN P., VOGT D., BLOOD A., HERMESZ E., WESTPHAL H., et al. Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014; 385(1):94-106.10.1016/j.ydbio.2013.10.010388289224157949Search in Google Scholar

12. NAT R., SALTI A., SUCIU L., STRÖM S., DECHANT G. Pharmacological modulation of the hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development. Stem Cells Dev. 2012; 21(7):1016–1046.10.1089/scd.2011.027122204396Search in Google Scholar

13. ZHAO Y., FLANDIN P., LONG JE., CUESTA MD., WESTPHAL H., RUBENSTEIN JL. Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol. 2008; 510(1):79–99.10.1002/cne.21772254749418613121Search in Google Scholar

14. DU T., XU Q., OCBINA PJ., ANDERSON SA. NKX2.1 specifies cortical interneuron fate by activating Lhx6. Development. 2008; 135(8):1559-1567.10.1242/dev.01512318339674Search in Google Scholar

15. GEORGIEV D., GONZÁLEZ-BURGOS G., KIKUCHI M., MINABE Y., LEWIS DA., HASHIMOTO T. Selective expression of KCNS3 potassium channel α-subunit in parvalbumin-containing GABA neurons in the human prefrontal cortex. PLoS One. 2012; 7(8): e43904.10.1371/journal.pone.0043904342716722937123Search in Google Scholar

16. JAKOVCEVSKI I., MAYER N., ZECEVIC N. Multiple origins of human neocortical interneurons are supported by distinct expression of transcription factors. Cereb Cortex. 2011; 21(8):1771-1782.10.1093/cercor/bhq245313851121139075Search in Google Scholar

17. CESARIO JM., MALT AL., DEACON LJ., SANDBERG M., VOGT D., TANG Z., et al. Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015; 24(17):5024-5039.10.1093/hmg/ddv223452749526071365Search in Google Scholar

18. ZHAO M., GUPTA V., RAJ L., ROUSSEL M., BEI M. A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol. 2013; 33(16): 3099-3112.10.1128/MCB.00524-13375389723754753Search in Google Scholar

19. ZHANG Z., GUTIERREZ D., LI X., BIDLACK F., CAO H., WANG J., et al. The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis. J Biol Chem. 2013; 288(4):2485-2500.10.1074/jbc.M112.402933355491723229549Search in Google Scholar

20. DENAXA M., SHARPE PT., PACHNIS V. The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009; 33(2):324-336.10.1016/j.ydbio.2009.07.001273895219591819Search in Google Scholar

21. ARANY S., NAKATA A., KAMEDA T., KOYOTA S., UENO Y., SUGIYAMA T. Phenotype properties of a novel spontaneously immortalized odontoblast-lineage cell line. Biochem Biophys Res Commun. 2006; 342(3):718-724.10.1016/j.bbrc.2006.02.02016494847Search in Google Scholar

22. PRIAM F., RONCO V., LOCKER M., BOURD K., BONNEIFOIX M., DUCHÊNE T., et al. New cellular models for tracking the odontoblast phenotype. Arch Oral Biol. 2005; 50(2):271-277.10.1016/j.archoralbio.2004.10.00715721161Search in Google Scholar

23. ZHANG Y., MORI T., TAKAKI H., TAKEUCHI M., ISEKI K., HAGINO S., et al. Comparison of the expression patterns of two LIM-homeodomain genes, Lhx6 and L3/Lhx8, in the developing palate. Orthod Craniofac Res. 2002; 5(2):65-70.10.1034/j.1600-0544.2002.02198.x12086327Search in Google Scholar

24. MOHER D., LIBERATI A., TETZLAFF J., ALTMAN DG., PRISMA GROUP. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097.10.1371/journal.pmed.1000097270759919621072Search in Google Scholar

25. YANG J., HAN F., LIU W., ZHANG M., HUANG Y., HAO X., et al. LHX6, an independent prognostic factor, inhibits lung adenocarcinoma progression through transcriptional silencing of β-catenin. J Cancer. 2017; 8(13):2561-2574.10.7150/jca.19972559508628900494Search in Google Scholar

26. HU Z., XIE L. LHX6 inhibits breast cancer cell proliferation and invasion via repression of the Wnt/β-catenin signaling pathway. Mol Med Rep. 2015; 12(3):4634-4639.10.3892/mmr.2015.399726129710Search in Google Scholar

27. LIU W-B., JIANG X., HAN F., LI Y-H., CHEN H-Q., LIU Y., et al. LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer. Cell Death Dis. 2013; 4(10):e882.10.1038/cddis.2013.366382467524157876Search in Google Scholar

28. JUNG S., JEONG D., KIM J., YI L., KOO K., LEE J., et al. Epigenetic regulation of the potential tumor suppressor gene, hLHX6.1, in human cervical cancer. Int J Oncol. 2011; 38(3):859-869.10.3892/ijo.2011.904Search in Google Scholar

29. JUNG S., JEONG D., KIM J., YI L., KOO K., LEE J., et al. The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer. Oncol Rep. 2010; 23(6):1675-1682.10.3892/or_00000811Search in Google Scholar

30. LIAO J., LIN J., LIN D., ZOU C., KURATA J., LIN R., HE Z., SU Y. Down-regulation of miR-214 reverses erlotinib resistance in non-small-cell lung cancer through up-regulating LHX6 expression. Sci Rep. 2017; 7(1):781.10.1038/s41598-017-00901-6542970728396596Search in Google Scholar

31. LIN CJ., GRANDIS JR., CAREY TE., GOLLIN SM., WHITESIDE TL., KOCH WM., et al. Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head and Neck. 2007; 29(2):163-188.10.1002/hed.2047817312569Search in Google Scholar

32. HOLLIDAY DL., SPEIRS V. Choosing the right cell line for breast cancer research. Breast Cancer Res. 2011; 13(4):215.10.1186/bcr2889323632921884641Search in Google Scholar

33. HARRIS CP., LU XY., NARAYAN G., SINGH B., MURTY VVVS., RAO PH. Comprehensive molecular cytogenetic characterization of cervical cancer cell lines. Genes Chromosome Cancer. 2003; 36(3):233-241.10.1002/gcc.1015812557223Search in Google Scholar

34. GAZDAR AF., GIRARD L., LOCKWOOD WW., LAM WL., MINNA JD. Lung cancer cell lines as tools for biomedical discovery and research. J Natl Cancer Inst. 2010; 102(17):1310-1321.10.1093/jnci/djq279293547420679594Search in Google Scholar

35. NANNI P., DE GIOVANNI C., LOLLINI PL., NICOLETTI G., PRODI G. TS/A: A new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma. Clin Exp Metastasis. 1983; 1(4):373-380.10.1007/BF001211996546207Search in Google Scholar

36. GHARIB A., FAEZIZADEH Z., MESBAH-NAMIN SAR., SARAVANI R. Experimental treatment of breast cancer-bearing BALB/c mice by artemisinin and transferrin-loaded magnetic nanoliposomes. Pharmacogn Mag. 2015; 11(Suppl 1):S117-S122.10.4103/0973-1296.157710446195026109756Search in Google Scholar