INFORMAZIONI SU QUESTO ARTICOLO

Cita

Figure 1.

PRISMA diagram
PRISMA diagram

Figure 2.

Anaesthetics and opioids consumption (in morphine equivalents, mg/kg).
Anaesthetics and opioids consumption (in morphine equivalents, mg/kg).

Figure 3.

Pain intensity (out of 10).
Pain intensity (out of 10).

Figure 4.

Time to first opioid/analgesic request (min).
Time to first opioid/analgesic request (min).

Characteristics of included studies

Author, citation Country Study design Study goals Age Number of patients: total (intervention/control) Group Surgery General anesthesia ASA Local anesthetics, volume and concentration Adjuvants to local anesthetics
Cho et al., 2018 South Korea RCT Primary: post-operative VNRS pain scores, total number of rescue analgesics used in 48 hours after the operation 21-60 Mean (SD): Intervention –39.6(9.8) Control –41.7(11.3) 60 (30/30) Intervention: ultrasound-guided RSB Control: no block Gynecologic laparoscopic surgery Yes I-II 7.5 mL 0.25% ropi-vacaine bilaterally Fentanyl, ketorolac
Cowlishaw et al., 2017 - RCT Analgesic and antiemetic consumption, pain scores (VAS), nausea, vomiting, and satisfaction 54-56 88 (29/29/30) - (SC/PRS/TAP) Intervention: TAP – transversus abdominis plane catheter, PRS – posterior rectus sheath catheter, SC – subcutaneous catheter Mid line Laparotomy surgery No 18 mL 0.5% ropivacaine via catheter Dexamethasone, Metoclopramide, Paracetamol, NSAIDs
Kartalov et al., 2017 North Macedonia RCT Primary: VAS pain scores, total morphine dose over 24 hours Mean (SD): Intervention –41.3(15.8) Control –42.4(14.7) 60 (30/30) Intervention: general anesthesia with RSB Control: no block Umbilical hernia repair surgery Yes I-II 20 mL 0.25% bupi-vacaine bilaterally Paracetamol, morphine IV
Kauffman et al., 2020 USA RCT Primary: pain score 60 minutes after the PACU arrival Secondary: pain (PACU), length of PACU stay, outpatient pain scores, outpatient opioid use, adverse events. 10-21 Total: 15.3(3.1), control: 15.8(1.6), intervention: 14.83(4.0) 48 (24/24) Intervention: laparoscopic-guided RSB. Control: trans-incisional RSB Single-incision laparoscopic cholecystectomy surgery (gail-bladder removal) Yes I-II 0.5 mL/kg 0.2% ropivacaine hydrochloride bilaterally (total 1 mL/kg, total maximum dose 10 mL) Ondansetron IV, dexamethasone, glycopyrrolate
Li et al., 2019 China RCT Primary: incidence of positive hemodynamic response at incision, incidence of moderate pain postoperatively Secondary: intraoperative sufentanyl, time to eye opening, time to extubation, time to oxycodone request, duration of sensory block 46-70 Mean (SD):Group B – 58.0 (8.3), Group C – 56.4 (8.6), Group D – 58.7 (7.1), Group BD – 57.1 (8.3) 85 (66/19) 1 control group: 19 (Group C) 3 intervention groups: 22 (Group B), 21 (Group D) and 23 (Group BD) Intervention: ultrasound-guided RSB (Group B), dexmedetomidine infusion (Group D), both RSB and dexmedetomidine (Group BD) Control: nothing (Group C) Open gastrectomy surgery (stomach removal) Yes I-III Group B: 20 mL 0.375% ropivacaine diluted in 0.9% saline bilaterally only Group D: initial dose 0.6 μg/kg dexmedetomidine followed by continuous infusion 0.2 μg/kg/h during surgery then followed by 10 μg sufentanyl Group BD: combination of Group B analgesics first followed by Group D analgesics Dexmedetomidine, sufentanyl
Murouchi et al., 2015 USA RCT Concentration changes of Ropivacaine and analgesic effects 18-85 22 (11/11) Intervention: RSB Control: TAPB laparoscopic ovarian surgery Yes I-II 30mL 0.5% ropivacaine bilaterally, 15mL per side droperidol, acetaminophen
Xu et al., 2018 China RCT Primary: effectiveness and safety 75-77 60 (30/30) -(R+D/R) Intervention: R+D (10mL0.25% ropivacaine + 0.5 μg/kg dexmedetomidine); R (10 mL 0.25% ropivacaine) Emergency abdominal surgery Patient-controlled intravenous analgesia (PCIA) II-III 10 mL 0.25% ropivacaine, + 0.5 μg/kg dexmedetomidine bilaterally Sufentanil, Cardiovascular medications
Yentis et al., 1999 UK RCT Pain scores, morphine requirements 32-71 37(21/16) Intervention: midline incisions Control: transverse incisions abdominal gynecological surgery Yes I-II Up to 60 ml bupivacaine 0.25% adrenaline 1:400 000

Jadad Scale

Study or subgroup Was this study described as randomized? Was the method used to generate the sequence of randomization appropriate and described? Was the study described as double-blind? Was the method of double blind appropriate and described? Was there a description of withdraw and dropouts? Total score
Cho 2018 1 1 0 0 1 3
Cowlishaw 2017 1 1 1 1 1 5
Kartalov 2017 1 0 1 0 0 2
Kauffman 2020 1 0 1 1 1 4
Li 2019 1 1 1 1 1 5
Murouchi 2015 1 0 0 0 0 1
Xu 2018 1 1 1 0 1 4
Yentis 1999 1 1 1 0 0 3
eISSN:
2502-0307
Lingua:
Inglese
Frequenza di pubblicazione:
2 volte all'anno
Argomenti della rivista:
Medicine, Clinical Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine