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Comparison of two different doses of dexmedetomidine added to lignocaine in patients posted for upper limb orthopedic surgery under intravenous regional anaesthesia

Mostafa Saieed Mansour
Mostafa Saieed Mansour
, 
Shebin El Kom
Shebin El Kom
, 
Mohamed Ahmed
Mohamed Ahmed
, 
Ayman Rady
Ayman Rady
 e 
Sadik Sadik
Sadik Sadik
   | 29 dic 2022
Romanian Journal of Anaesthesia and Intensive Care's Cover Image
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Article Category: Original Paper
Pubblicato online: 29 dic 2022
Pagine: 63 - 70
DOI: https://doi.org/10.2478/rjaic-2021-0011
Parole chiave
© 2021 Mansour et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Comparison between groups according to heart rate (beat/min).
Comparison between groups according to heart rate (beat/min).

Figure 2

Comparison between groups according to mean arterial blood pressure (mmHg).
Comparison between groups according to mean arterial blood pressure (mmHg).

Figure 3

Comparison between groups according to respiratory rate (b/min).
Comparison between groups according to respiratory rate (b/min).

Comparison among groups according to demographic data.

Demographic data Group I: Control (n=30) Group II: Dex 0.25 μg/kg (n=30) Group III: Dex 0.50 μg/kg (n=30) Test p-value
Age (years)          
Range 20-70 21-70 20-69    
      F = 0.935 0.397
Mean ± SD 41.54 ± 7.06 39.04 ± 6.92 40.60 ± 7.47    
Sex          
Male 23 (76.7%) 26 (86.7%) 24 (80.0%)    
Female 7 (23.3%) 4 (13.3%) 6 (20.0%) x2 = 1.015 0.602
ASA          
I 21 (70.0%) 22 (73.3%) 19 (63.3%)    
      x2 = 0.726 0.696
II 9 (30.0%) 8 (26.7%) 11 (36.7%)    
Duration of surgery          
(min)          
Range 28-60 25-59 27-58    
      F = 0.930 0.399
Mean ± SD 43.84 ± 7.45 41.21 ± 7.30 42.86 ± 7.89    

Comparison between groups in terms of block and mean duration of tourniquet time.

Block (min) Group I: Control (n=30) Group II: Dex 0.25 μg/kg (n=30) Group III: Dex 0.50 μg/kg (n=30) Test p-value
Onset block of (min) sensory 4.96 ± 0.90 3.92 ± 0.92a 1.06 ± 0.35ab F = 206.345 <0.001**
Onset block of (min) motor 12.80 ± 2.16 10.69 ± 2.20a 5.34 ± 1.16ab F = 122.649 <0.001**
Quality of block          
Excellent 15 (50.0%) 24 (80.0%) 26 (86.7%)    
Good 8 (26.7%) 4 (13.3%) 3 (10.0%) x2 = 13.219 0.040*
Fair 5 (16.7%) 2 (6.7%) 1 (3.3%)    
Poor 2 (6.7%) 0 (0.0%) 0 (0.0%)    
Mean duration of tourniquet time (min)          
Mean ± SD 52.77 ± 4.58 55.06 ± 5.20 54.28 ± 4.82 1.712 0.187

Comparison between groups according to complications.

Complications Group I: Control (n=30) Group II: Dex 0.25 μg/kg (n=30) Group III: Dex 0.50 μg/kg (n=30) x2 p-value
Dry mouth 1 (3.3%) 2 (6.7%) 3 (10.0%)    
Bradycardia 0 (0.0%) 1 (3.3%) 2 (6.7%)    
Tinnitus 0 (0.0%) 1 (3.3%) 2 (6.7%) 8.280 0.407
Perioral numbness 0 (0.0%) 1 (3.3%) 2 (6.7%)    
Nil 29 (96.7%) 25 (83.3%) 21 (70.0%)    

Comparison between groups according to sedation score (after tourniquet deflation), VAS score duration of analgesia, doses needed of analgesic and total dose of ketorolac.

Sedation score (after tourniquet deflation) Group I: Control (n=30) Group II: Dex 0.25 μg/ kg (n=30) Group III: Dex 0.50 μg/ kg (n=30) Test p-value
After 20 min 2 (1-4) 2 (1-4) 2 (1-4) 1.713 0.207
After 40 min 1 (1-3) 1 (1-3) 1 (1-3) 1.117 0.186
After 60 min 1 (1-2) 1 (1-2) 1 (1-2) 1.440 0.173
VAS score          
After 1 hr 1 (0-3) 1 (0-2) 0 (0-1) 1.679 0.201
After 2 hrs 3 (1-5) 2 (1-4)a 1 (0-2)ab 2.338 0.016*
After 3 hrs 5 (1-5) 3 (1-4)a 1 (1-2)ab 2.189 0.013*
After 4 hrs 4 (2-6) 3 (2-5)a 2 (1-4)ab 2.099 0.012*
After 5 hrs 5 (3-7) 4 (3-5)a 3 (1-4)ab 2.015 0.006*
Duration of analgesia       F-test  
Mean ± SD 108.27 ± 55.00 174.20 ± 67.08a 331.53 ± 78.27ab 86.746 <0.001**
Doses needed of analgesic       1.713 0.207
After 40 min 1 (1-3) 1 (1-3) 1 (1-3) 1.117 0.186
After 60 min 1 (1-2) 1 (1-2) 1 (1-2) 1.440 0.173
VAS score       x2  
1st dose 30 (100.0%) 30 (100.0%) 30 (100.0%) 0.000 1.000
2nd dose 30 (100.0%) 26 (86.7%) 17 (56.7%) 19.291 <0.001**
3rd dose 18 (60.0%) 12 (40.0%) 0 (0.0%) 25.200 <0.001**
4th dose 5 (16.7%) 0 (0.0%) 0 (0.0%) 10.588 0.005*
Total dose (Ketorolac mg/kg)       F-test  
Mean ± SD 83.75 ± 7.54 68.61 ± 6.18a 47.42 ± 4.27ab 264.587 <0.001**
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Medicine, Clinical Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine
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