Long-term results of induction chemotherapy for non-operable esophageal squamous cell carcinoma followed by concurrent chemoradiotherapy: a single-centre experience
State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital, Air Force Medical UniversityXi'an, China
This work is licensed under the Creative Commons Attribution 4.0 International License.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics 2021. CA Cancer J Clin 2021; 71: 7–33. doi: 10.3322/caac.21654SiegelRLMillerKDFuchsHEJemalACancer statistics 2021CA Cancer J Clin20217173310.3322/caac.21654Open DOISearch in Google Scholar
Smyth EC, Lagergren J, Fitzgerald RC, Lordick F, Shah MA, Lagergren P, et al. Oesophageal cancer. Nat Rev Dis Primers 2017; 3: 17048. doi: 10.1038/nrdp.2017.48SmythECLagergrenJFitzgeraldRCLordickFShahMALagergrenPOesophageal cancerNat Rev Dis Primers201731704810.1038/nrdp.2017.48Open DOISearch in Google Scholar
Arnold M, Soerjomataram I, Ferlay J, Forman D. Global incidence of oesophageal cancer by histological subtype in 2012. Gut 2015; 64: 381–7. doi: 10.1136/gutjnl-2014-308124ArnoldMSoerjomataramIFerlayJFormanDGlobal incidence of oesophageal cancer by histological subtype in 2012Gut201564381710.1136/gutjnl-2014-308124Open DOISearch in Google Scholar
Lagergren J, Smyth E, Cunningham D, Lagergren P. Oesophageal cancer. Lancet 2017; 390: 2383–96. doi: 10.1016/S0140-6736(17)31462-9LagergrenJSmythECunninghamDLagergrenPOesophageal cancerLancet201739023839610.1016/S0140-6736(17)31462-9Open DOISearch in Google Scholar
Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson Jr JA, Al-Sarraf M, et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 1999; 281: 1623–7. doi: 10.1001/jama.281.17.1623CooperJSGuoMDHerskovicAMacdonaldJSMartensonJAJrAl-SarrafMChemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology GroupJAMA19992811623710.1001/jama.281.17.1623Open DOISearch in Google Scholar
Gwynne S, Hurt C, Evans M, Holden C, Vout L, Crosby T. Definitive chemoradiation for oesophageal cancer: a standard of care in patients with non-metastatic oesophageal cancer. Clin Oncol 2011; 23: 182–8. doi: 10.1016/j.clon.2010.12.001GwynneSHurtCEvansMHoldenCVoutLCrosbyTDefinitive chemoradiation for oesophageal cancer: a standard of care in patients with non-metastatic oesophageal cancerClin Oncol201123182810.1016/j.clon.2010.12.001Open DOISearch in Google Scholar
Xi M, Xu C, Liao ZX, Hofstetter WL, Murphy MB, Maru DM, et al. The impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapy. Radiother Oncol 2017; 124: 318–24. doi: 10.1016/j.radonc.2017.06.019XiMXuCLiaoZXHofstetterWLMurphyMBMaruDMThe impact of histology on recurrence patterns in esophageal cancer treated with definitive chemoradiotherapyRadiother Oncol20171243182410.1016/j.radonc.2017.06.019Open DOISearch in Google Scholar
Sudo K, Xiao L, Wadhwa R, Shiozaki H, Elimova E, Taketa T, et al. Importance of surveillance and success of salvage strategies after definitive chemoradiation in patients with esophageal cancer. J Clin Oncol 2014; 32: 3400–5. doi: 10.1200/JCO.2014.56.7156SudoKXiaoLWadhwaRShiozakiHElimovaETaketaTImportance of surveillance and success of salvage strategies after definitive chemoradiation in patients with esophageal cancerJ Clin Oncol2014323400510.1200/JCO.2014.56.7156Open DOISearch in Google Scholar
Liu SL, Luo LL, Zhao L, Zhu YJ, Liu H, Li QQ, et al. Induction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinoma: a randomized phase II trial. Nat Commun 2021; 12: 4014. doi: 10.1038/s41467-021-24288-1LiuSLLuoLLZhaoLZhuYJLiuHLiQQInduction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinoma: a randomized phase II trialNat Commun202112401410.1038/s41467-021-24288-1Open DOISearch in Google Scholar
Sun Y, Li WF, Chen NY, Zhang N, Hu GQ, Xie FY, et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomized controlled trial. Lancet Oncol 2016; 17: 1509–20. doi: 10.1016/S1470-2045(16)30410-7SunYLiWFChenNYZhangNHuGQXieFYInduction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomized controlled trialLancet Oncol20161715092010.1016/S1470-2045(16)30410-7Open DOISearch in Google Scholar
Chen MQ, Lin QL, Chen YG, Guo JH, Xu BH, Tian Y. Neoadjuvant chemotherapy may not benefit esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy. J Chin Med Assoc 2017; 80: 636. doi: 10.1016/j.jcma.2017.06.014ChenMQLinQLChenYGGuoJHXuBHTianYNeoadjuvant chemotherapy may not benefit esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapyJ Chin Med Assoc20178063610.1016/j.jcma.2017.06.014Open DOISearch in Google Scholar
Luo LL, Xi M, Yang YD, Li QQ, Zhao L, Zhang P, et al. Comparative outcomes of induction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinoma. J Cancer 2017; 8: 3441–7. doi: 10.7150/jca.21131LuoLLXiMYangYDLiQQZhaoLZhangPComparative outcomes of induction chemotherapy followed by definitive chemoradiotherapy versus chemoradiotherapy alone in esophageal squamous cell carcinomaJ Cancer201783441710.7150/jca.21131Open DOISearch in Google Scholar
Akinori M, Michitaka H, Yousuke I, Tsuyoshi K, Tairo R, Gencho K, et al. Induction chemotherapy followed by chemoradiotherapy for T4M0 esophageal cancer. Esophagus 2011; 8: 31–7. doi: 10.1007/s10388-011-0255-yAkinoriMMichitakaHYousukeITsuyoshiKTairoRGenchoKInduction chemotherapy followed by chemoradiotherapy for T4M0 esophageal cancerEsophagus2011831710.1007/s10388-011-0255-yOpen DOISearch in Google Scholar
Jin J, Liao ZX, Zhang Z, Ajani J, Swisher S, Chang JY, et al. Induction chemotherapy improved outcomes of patients with resectable esophageal cancer who received chemoradiotherapy followed by surgery. Int J Radiat Oncol Biol Phys 2004; 60: 427–36. doi: 10.1016/j.ijrobp.2004.03.033JinJLiaoZXZhangZAjaniJSwisherSChangJYInduction chemotherapy improved outcomes of patients with resectable esophageal cancer who received chemoradiotherapy followed by surgeryInt J Radiat Oncol Biol Phys2004604273610.1016/j.ijrobp.2004.03.033Open DOISearch in Google Scholar
Malaisrie SC, Hofstetter WL, Correa AM, Ajani JA, Komaki RR, Rice DC, et al. The addition of induction chemotherapy to preoperative, concurrent chemoradiotherapy improves tumor response in patients with esophageal adenocarcinoma. Cancer 2006; 107: 967–74. doi: 10.1002/cncr.22077MalaisrieSCHofstetterWLCorreaAMAjaniJAKomakiRRRiceDCThe addition of induction chemotherapy to preoperative, concurrent chemoradiotherapy improves tumor response in patients with esophageal adenocarcinomaCancer20061079677410.1002/cncr.22077Open DOISearch in Google Scholar
Li C, Wang X, Wang L, Chen JQ, Zhang WC, Pang QS, et al. Clinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG Survey. Acta Oncologica 2021; 60: 627–34. doi: 10.1080/0284186X.2021.1902564LiCWangXWangLChenJQZhangWCPangQSClinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG SurveyActa Oncologica2021606273410.1080/0284186X.2021.1902564Open DOISearch in Google Scholar
Lyu B, Yin YT, Zhao YL, Yang X, Gong J, Zhang M, et al. Long-term clinical outcomes and safety analysis of superficial esophageal cancer patients treated with definitive or adjuvant radiotherapy. Cancers 2022; 14: 3423. doi: 10.3390/cancers14143423LyuBYinYTZhaoYLYangXGongJZhangMLong-term clinical outcomes and safety analysis of superficial esophageal cancer patients treated with definitive or adjuvant radiotherapyCancers202214342310.3390/cancers14143423Open DOISearch in Google Scholar
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1). Eur J Cancer 2009; 45: 228–47. doi: 10.1016/j.ejca.2008.10.026EisenhauerEATherassePBogaertsJSchwartzLHSargentDFordRNew response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1)Eur J Cancer2009452284710.1016/j.ejca.2008.10.026Open DOISearch in Google Scholar
Wang JN, Xiao LL, Wang S, Pang QS, Wang J. Addition of induction or consolidation chemotherapy in definitive concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone for patients with unresectable esophageal cancer: a systematic review and meta-analysis. Front Oncol 2021; 11: 665231. doi: 10.3389/fonc.2021.665231WangJNXiaoLLWangSPangQSWangJAddition of induction or consolidation chemotherapy in definitive concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone for patients with unresectable esophageal cancer: a systematic review and meta-analysisFront Oncol20211166523110.3389/fonc.2021.665231Open DOISearch in Google Scholar
Wu HS, Yu YL, Zheng QH, Liu TX, Wu YH, Wang ZP, et al. Benefit of chemotherapy based on platinum with definitive radiotherapy in older patients with locally advanced esophageal squamous cell carcinoma. Radiat Oncol 2021; 16: 1–14. doi: 10.1186/s13014-021-01931-1WuHSYuYLZhengQHLiuTXWuYHWangZPBenefit of chemotherapy based on platinum with definitive radiotherapy in older patients with locally advanced esophageal squamous cell carcinomaRadiat Oncol20211611410.1186/s13014-021-01931-1Open DOISearch in Google Scholar
Hsieh JCH, Chiang PC, Hung TM, Chao YK, Kuo YC, Wen CT, et al. Definitive concurrent chemoradiotherapy with paclitaxel plus carboplatin is superior to cisplatin plus 5-fluorouracil in patients with inoperable esophageal squamous cell carcinoma using retrospective, real-world evidence. Cancer Med 2021; 10: 8300–9. doi: 10.1002/cam4.4025HsiehJCHChiangPCHungTMChaoYKKuoYCWenCTDefinitive concurrent chemoradiotherapy with paclitaxel plus carboplatin is superior to cisplatin plus 5-fluorouracil in patients with inoperable esophageal squamous cell carcinoma using retrospective, real-world evidenceCancer Med2021108300910.1002/cam4.4025Open DOISearch in Google Scholar
Sher DJ, Posner MR, Tishler RB, Sarlis NJ, Haddad RI, Holupka EJ, et al. Relationship between radiation treatment time and overall survival after induction chemotherapy for locally advanced head-and-neck carcinoma: a subset analysis of TAX 324. Int J Radiat Oncol Biol Phys 2011; 81: 813–8. doi: 10.1016/j.ijrobp.2010.12.005SherDJPosnerMRTishlerRBSarlisNJHaddadRIHolupkaEJRelationship between radiation treatment time and overall survival after induction chemotherapy for locally advanced head-and-neck carcinoma: a subset analysis of TAX 324Int J Radiat Oncol Biol Phys201181813810.1016/j.ijrobp.2010.12.005Open DOISearch in Google Scholar
Cannon DM, Geye HM, Hartig GK, Traynor AM, Hoang T, McCulloch TM, et al. Increased local failure risk with prolonged radiation treatment time in head and neck cancer treated with concurrent chemotherapy. Head Neck 2014; 36: 1120–5. doi: 10.1002/hed.23419CannonDMGeyeHMHartigGKTraynorAMHoangTMcCullochTMIncreased local failure risk with prolonged radiation treatment time in head and neck cancer treated with concurrent chemotherapyHead Neck2014361120510.1002/hed.23419Open DOISearch in Google Scholar
Xu C, Xi M, Moreno A, Shiraishi Y, Hobbs BP, Huang ML, et al. Definitive chemoradiation therapy for esophageal cancer in the elderly: clinical outcomes for patients exceeding 80 years old. Int J Radiat Oncol Biol Phys 2017; 98: 811–9. doi: 10.1016/j.ijrobp.2017.02.097XuCXiMMorenoAShiraishiYHobbsBPHuangMLDefinitive chemoradiation therapy for esophageal cancer in the elderly: clinical outcomes for patients exceeding 80 years oldInt J Radiat Oncol Biol Phys201798811910.1016/j.ijrobp.2017.02.097Open DOISearch in Google Scholar
Cai YL, Lin YX, Jiang LS, Ye H, Li FY, Cheng NS. A novel nomogram predicting distant metastasis in T1 and T2 gallbladder cancer: a SEER-based study. Int J Med Sci 2020; 17: 1704–12. doi: 10.7150/ijms.47073CaiYLLinYXJiangLSYeHLiFYChengNSA novel nomogram predicting distant metastasis in T1 and T2 gallbladder cancer: a SEER-based studyInt J Med Sci20201717041210.7150/ijms.47073Open DOISearch in Google Scholar
Colzani E, Johansson ALV, Liljegren A, Foukakis T, Clements M, Adolfsson J, et al. Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics. Br J Cancer 2014; 110: 1378–84. doi: 10.1038/bjc.2014.5ColzaniEJohanssonALVLiljegrenAFoukakisTClementsMAdolfssonJTime-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristicsBr J Cancer201411013788410.1038/bjc.2014.5Open DOISearch in Google Scholar
Hemminki K, Pavlidis N, Tsilidis KK, Sundquist K, Ji J. Age-dependent metastatic spread and survival: Cancer of unknown primary as a model. Sci Rep 2016; 6: 23725. doi: 10.1038/srep23725HemminkiKPavlidisNTsilidisKKSundquistKJiJAge-dependent metastatic spread and survival: Cancer of unknown primary as a modelSci Rep201662372510.1038/srep23725Open DOISearch in Google Scholar
Kumabe A, Zenda S, Motegi A, Onozawa M, Nakamura N, Kojima T, et al. Long-term clinical results of concurrent chemoradiotherapy for patients with cervical esophageal squamous cell carcinoma. Anticancer Res 2017; 37: 5039–44. doi: 10.21873/anticanres.11919KumabeAZendaSMotegiAOnozawaMNakamuraNKojimaTLong-term clinical results of concurrent chemoradiotherapy for patients with cervical esophageal squamous cell carcinomaAnticancer Res20173750394410.21873/anticanres.11919Open DOISearch in Google Scholar
Minsky BD, Neuberg D, Kelsen DP, Pisansky TM, Ginsberg RJ, Pajak T, et al. Final report of Intergroup Trial 0122 (ECOG PE-289, RTOG 90-12): phase II trial of neoadjuvant chemotherapy plus concurrent chemotherapy and high-dose radiation for squamous cell carcinoma of the esophagus. Int J Radiat Oncol Biol Phys 1999; 43: 517–23. doi: 10.1016/s0360-3016(98)00463-5MinskyBDNeubergDKelsenDPPisanskyTMGinsbergRJPajakTFinal report of Intergroup Trial 0122 (ECOG PE-289, RTOG 90-12): phase II trial of neoadjuvant chemotherapy plus concurrent chemotherapy and high-dose radiation for squamous cell carcinoma of the esophagusInt J Radiat Oncol Biol Phys1999435172310.1016/s0360-3016(98)00463-5Open DOISearch in Google Scholar
Ohtsu A, Boku N, Muro K, Chin K, Muto M, Yoshida S, et al. Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol 1999; 17: 2915–21. doi: 10.1200/JCO.1999.17.9.2915OhtsuABokuNMuroKChinKMutoMYoshidaSDefinitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagusJ Clin Oncol19991729152110.1200/JCO.1999.17.9.2915Open DOISearch in Google Scholar
Shinoda M, Ando N, Kato K, Ishikura S, Kato H, Tsubosa Y, et al. Randomized study of low-dose versus standard-dose chemoradiotherapy for unresectable esophageal squamous cell carcinoma (JCOG0303). Cancer Sci 2015; 106: 407–12. doi: 10.1111/cas.12622ShinodaMAndoNKatoKIshikuraSKatoHTsubosaYRandomized study of low-dose versus standard-dose chemoradiotherapy for unresectable esophageal squamous cell carcinoma (JCOG0303)Cancer Sci20151064071210.1111/cas.12622Open DOISearch in Google Scholar
Chan C, Lang S, Rowbottom C, Guckenberger M, Faivre-Finn C. Intensity-modulated radiotherapy for lung cancer: current status and future developments. J Thorac Oncol 2014; 9: 1598–608. doi: 10.1097/JTO.0000000000000346ChanCLangSRowbottomCGuckenbergerMFaivre-FinnCIntensity-modulated radiotherapy for lung cancer: current status and future developmentsJ Thorac Oncol20149159860810.1097/JTO.0000000000000346Open DOISearch in Google Scholar