The influence of anaesthesia on cancer growth

1. Sherwin A, Wall T, Buggy DJ. Anesthesia and cancer recurrence. UpToDate. [Internet]. Wolters Kluwer. [cited 2023 Sep 4). Available at: https://www.uptodate.com/contents/anesthesia-and-cancer-recurrence SherwinA WallT BuggyDJ Anesthesia and cancer recurrence UpToDate [Internet]. Wolters Kluwer. [cited 2023 Sep 4). Available at: https://www.uptodate.com/contents/anesthesia-and-cancer-recurrence Search in Google Scholar

2. Sessler DI, Riedel B. Anesthesia and cancer recurrence: context for divergent study outcomes. Anesthesiology 2019; 130: 3–5. doi: 10.1097/ALN.0000000000002506 SesslerDI RiedelB Anesthesia and cancer recurrence: context for divergent study outcomes Anesthesiology 2019 130 3 5 10.1097/ALN.0000000000002506 Open DOISearch in Google Scholar

3. Lyden D, Ghajar CM, Correia AL, Aguirre-Ghiso JA, Cai S, Rescigno M, et al. Metastasis. Cancer Cell 2022; 40: 787–91. doi: 10.1016/j.ccell.2022.07.010 LydenD GhajarCM CorreiaAL Aguirre-GhisoJA CaiS RescignoM Metastasis Cancer Cell 2022 40 787 91 10.1016/j.ccell.2022.07.010 Open DOISearch in Google Scholar

4. Margraf A, Ludwig N, Zarbock A, Rossaint J. Systemic inflammatory response syndrome after surgery: mechanisms and protection. Anesth Analg 2020; 131: 1693–707. doi: 10.1213/ANE.0000000000005175 MargrafA LudwigN ZarbockA RossaintJ Systemic inflammatory response syndrome after surgery: mechanisms and protection Anesth Analg 2020 131 1693 707 10.1213/ANE.0000000000005175 Open DOISearch in Google Scholar

5. Dinarello CA. Historical insights into cytokines. Eur J Immunol 2007; 37(Suppl 1): S34–45. doi: 10.1002/eji.200737772 DinarelloCA Historical insights into cytokines Eur J Immunol 2007 37 Suppl 1 S34 45 10.1002/eji.200737772 Open DOISearch in Google Scholar

6. Tavare AN, Perry NJ, Benzonana LL, Takata M, Ma D. Cancer recurrence after surgery: direct and indirect effects of anesthetic agents. Int J Cancer 2012; 130: 1237–50. doi: 10.1002/ijc.26448 TavareAN PerryNJ BenzonanaLL TakataM MaD Cancer recurrence after surgery: direct and indirect effects of anesthetic agents Int J Cancer 2012 130 1237 50 10.1002/ijc.26448 Open DOISearch in Google Scholar

7. Egger G. [Acute inflammation: basics, pathophysiology and clinical manifestations of non-specific imunity]. [German]. Wien, New York: Springer Verlag; 2005. EggerG [Acute inflammation: basics, pathophysiology and clinical manifestations of non-specific imunity]. [German] Wien, New York Springer Verlag 2005 Search in Google Scholar

8. Brøchner AC, Toft P. Pathophysiology of the systemic inflammatory response after major accidental trauma. Scand J Trauma Resusc Emerg Med 2009; 17: 43. doi: 10.1186/1757-7241-17-43 BrøchnerAC ToftP Pathophysiology of the systemic inflammatory response after major accidental trauma Scand J Trauma Resusc Emerg Med 2009 17 43 10.1186/1757-7241-17-43 Open DOISearch in Google Scholar

9. Potočnik I, Novak-Janković V, Šostarič M, Jerin A, Štupnik T, Skitek M, et al. Antiinflammatory effect of sevoflurane in open lung surgery with one-lung ventilation. Croat Med J 2014; 55: 628–37. doi: 10.3325/cmj.2014.55.628 PotočnikI Novak-JankovićV ŠostaričM JerinA ŠtupnikT SkitekM Antiinflammatory effect of sevoflurane in open lung surgery with one-lung ventilation Croat Med J 2014 55 628 37 10.3325/cmj.2014.55.628 Open DOISearch in Google Scholar

10. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med 2021; 47: 1181–247. doi: 10.1007/s00134-021-06506-y EvansL RhodesA AlhazzaniW AntonelliM CoopersmithCM FrenchC Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Intensive Care Med 2021 47 1181 247 10.1007/s00134-021-06506-y Open DOISearch in Google Scholar

11. Vincent JL. Update on surgical sepsis syndrome. Br J Surg 2017; 104: e34–40, doi: 10.1002/bjs.10451 VincentJL Update on surgical sepsis syndrome Br J Surg 2017 104 e34 40 10.1002/bjs.10451 Open DOISearch in Google Scholar

12. Stevenson GW, Hall SC, Rudnick S, Seleny FL, Stevenson HC. The effect of anesthetic agents on the human immune response. Anesthesiology 1990; 72: 542–52. doi: 10.1097/00000542-199003000-00024 StevensonGW HallSC RudnickS SelenyFL StevensonHC The effect of anesthetic agents on the human immune response Anesthesiology 1990 2 542 52 10.1097/00000542-199003000-00024 Open DOISearch in Google Scholar

13. Colucci DG, Puig NR, Hernandez-Pand R. Influence of anaesthetic drugs on immune response: from inflammation to immunosuppression. OA Anaesthetics 2013; 30: 21. doi: 10.13172/2052-7853-1-3-1091 ColucciDG PuigNR Hernandez-PandR Influence of anaesthetic drugs on immune response: from inflammation to immunosuppression OA Anaesthetics 2013 30 21 10.13172/2052-7853-1-3-1091 Open DOISearch in Google Scholar

14. Crozier TA, Müller JE, Quittkat D, Sydow M, Wuttke W, Kettler D. Effect of anaesthesia on the cytokine responses to abdominal surgery. Br J Anaesth 1994; 72: 280–5. doi: 10.1093/bja/72.3.280 CrozierTA MüllerJE QuittkatD SydowM WuttkeW KettlerD Effect of anaesthesia on the cytokine responses to abdominal surgery Br J Anaesth 1994 72 280 5 10.1093/bja/72.3.280 Open DOISearch in Google Scholar

15. Zhang Y, Lin JX, Vilcek J. Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP. J Biol Chem 1988; 263: 6177–82. PMID: 2452159 ZhangY LinJX VilcekJ Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP J Biol Chem 1988 263 6177 82 2452159 Search in Google Scholar

16. Lopker A, Abood LG, Hoss W, Lionetti FJ. Stereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes. Biochem Pharmacol 1980; 29: 1361–5. doi: 10.1016/0006-2952(80)90431-1 LopkerA AboodLG HossW LionettiFJ Stereoselective muscarinic acetylcholine and opiate receptors in human phagocytic leukocytes Biochem Pharmacol 1980 29 1361 5 10.1016/0006-2952(80)90431-1 Open DOISearch in Google Scholar

17. Rossano F, Tufano R, Cipollaro de L’Ero G, Servillo G, Baroni A, Tufano MA. Anesthetic agents induce human mononuclear leucocytes to release cytokines. Immunopharmacol Immunotoxicol 1992; 14: 439–50. doi: 10.3109/08923979209005403 RossanoF TufanoR Cipollaro de L’EroG ServilloG BaroniA TufanoMA Anesthetic agents induce human mononuclear leucocytes to release cytokines Immunopharmacol Immunotoxicol 1992 14 439 50 10.3109/08923979209005403 Open DOISearch in Google Scholar

18. Malafoglia V, Ilari S, Vitiello L, Tenti M, Balzani E, Muscoli C, et al. The interplay between chronic pain, opioids, and the immune system. Neuroscientist 2022; 28: 613–27. doi: 10.1177/10738584211030493 MalafogliaV IlariS VitielloL TentiM BalzaniE MuscoliC The interplay between chronic pain, opioids, and the immune system Neuroscientist 2022 28 613 27 10.1177/10738584211030493 Open DOISearch in Google Scholar

19. Dubowitz JA, Cata JP, De Silva AP, Braat S, Shan D, Yee K, et al. Global Onco-Anaesthesia Research Collaboration Group. Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large, randomised control trial. Anaesthesia 2021; 76: 1198–206. doi: 10.1111/anae.15354 DubowitzJA CataJP De SilvaAP BraatS ShanD YeeK Global Onco-Anaesthesia Research Collaboration Group. Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large, randomised control trial Anaesthesia 2021 76 1198 206 10.1111/anae.15354 Open DOISearch in Google Scholar

20. Galoș EV, Tat TF, Popa R, Efrimescu CI, Finnerty D, Buggy DJ, et al. Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial. Br J Anaesth 2020; 125: 712–21. doi: 10.1016/j.bja.2020.05.003 GaloșEV TatTF PopaR EfrimescuCI FinnertyD BuggyDJ Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial Br J Anaesth 2020 125 712 21 10.1016/j.bja.2020.05.003 Open DOISearch in Google Scholar

21. Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth 2008; 22: 263–77. doi: 10.1007/s00540-008-0626-2 KurosawaS KatoM Anesthetics, immune cells, and immune responses J Anesth 2008 22 263 77 10.1007/s00540-008-0626-2 Open DOISearch in Google Scholar

22. Salo M. Effects of lignocaine and bupivacaine on immunoglobulin synthesis in vitro. Eur J Anaesth 1990; 7: 133–40. SaloM Effects of lignocaine and bupivacaine on immunoglobulin synthesis in vitro Eur J Anaesth 1990 7 133 40 Search in Google Scholar

23. Novak-Jankovič V, Paver-Eržen V, Bovill JG, Ihan A, Osredkar J. Effect of epidural and intravenous clonidine on the neuro-endocrine and immune stress response in patients undergoing lung surgery. Eur J Anaesthesiol 2000;17: 50–6. doi:10.1046/j.1365-2346.2000.00602.x Novak-JankovičV Paver-ErženV BovillJG IhanA OsredkarJ Effect of epidural and intravenous clonidine on the neuro-endocrine and immune stress response in patients undergoing lung surgery Eur J Anaesthesiol 2000 17 50 6 10.1046/j.1365-2346.2000.00602.x Open DOISearch in Google Scholar

24. Novak-Jankovič V, Paver-Eržen V, Požlep G. How can we reduce stress response in patients undergoing lung surgery? Acta Med Croatica 1997; 51: 89. Novak-JankovičV Paver-ErženV PožlepG How can we reduce stress response in patients undergoing lung surgery? Acta Med Croatica 1997 51 89 Search in Google Scholar

25. Cata JP, Wang H, Gottumukkala V, Reuben J, Sessler DI. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth 2013; 110: 690–701. doi: 10.1093/bja/aet068 CataJP WangH GottumukkalaV ReubenJ SesslerDI Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions Br J Anaesth 2013 110 690 701 10.1093/bja/aet068 Open DOISearch in Google Scholar

26. Dantzer R. Neuroimmune interactions: from the brain to the immune system and vice versa. Physiol Rev 2018; 98: 1477–504. doi: 10.1152/physrev.00039.2016 DantzerR Neuroimmune interactions: from the brain to the immune system and vice versa Physiol Rev 2018 98 1477 504 10.1152/physrev.00039.2016 Open DOISearch in Google Scholar

27. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 2006; 8: 383–95. doi: 10.31887/DCNS.2006.8.4/ssmith SmithSM ValeWW The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress Dialogues Clin Neurosci 2006 8 383 95 10.31887/DCNS.2006.8.4/ssmith Open DOISearch in Google Scholar

28. Velkeniers B., Dogusan Z., Naessens F. et al. Prolactin, growth hormone and the immune system in humans. Cell Mol Life Sci 1998; 54: 1102–8. doi: 10.1007/s000180050239 VelkeniersB. DogusanZ. NaessensF. Prolactin, growth hormone and the immune system in humans Cell Mol Life Sci 1998 54 1102 8 10.1007/s000180050239 Open DOISearch in Google Scholar

29. Dhabhar FS. Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection versus immunopathology. 2008; Allergy Asthma Clin Immunol 2008; 4: 2–11. doi:10.1186/1710-1492-4-1-2 DhabharFS Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection versus immunopathology. 2008 Allergy Asthma Clin Immunol 2008 4 2 11 10.1186/1710-1492-4-1-2 Open DOISearch in Google Scholar

30. Sessler DI, Pei L, Huang Y, Fleischmann E, Marhofer P, Kurz A, et al; Breast Cancer Recurrence Collaboration. Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet 2019; 394: 1807–15. doi: 10.1016/S0140-6736(19)32313-X SesslerDI PeiL HuangY FleischmannE MarhoferP KurzA Breast Cancer Recurrence Collaboration Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial Lancet 2019 394 1807 15 10.1016/S0140-6736(19)32313-X Open DOISearch in Google Scholar

31. Du YT, Li YW, Zhao BJ, Guo XY, Feng Y, Zuo MZ, Fu C, et al; Peking University Clinical Research Program Study Group. Long-term survival after combined epidural-general anesthesia or general anesthesia alone: follow-up of a randomized trial. Anesthesiology 2021; 135: 233–45. doi: 10.1097/ALN.0000000000003835 DuYT LiYW ZhaoBJ GuoXY FengY ZuoMZ FuC Peking University Clinical Research Program Study Group Long-term survival after combined epidural-general anesthesia or general anesthesia alone: follow-up of a randomized trial Anesthesiology 2021 135 233 45 10.1097/ALN.0000000000003835 Open DOISearch in Google Scholar

32. Xu ZZ, Li HJ, Li MH, Huang SM, Li X, Liu QH, et al. Epidural anesthesia-analgesia and recurrence-free survival after lung cancer surgery: a randomized trial. Anesthesiology 2021; 135: 419–32. doi: 10.1097/ALN.0000000000003873 XuZZ LiHJ LiMH HuangSM LiX LiuQH Epidural anesthesia-analgesia and recurrence-free survival after lung cancer surgery: a randomized trial Anesthesiology 2021 135 419 32 10.1097/ALN.0000000000003873 Open DOISearch in Google Scholar

33. Vahabi S, Eatemadi A. Effects of anesthetic and analgesic techniques on cancer metastasis. Biomed Pharmacother 2017; 87: 1–7. doi: 10.1016/j.biopha.2016.12.073 VahabiS EatemadiA Effects of anesthetic and analgesic techniques on cancer metastasis Biomed Pharmacother 2017 87 1 7 10.1016/j.biopha.2016.12.073 Open DOISearch in Google Scholar

34. Potočnik I, Hostnik A, Markovič-Božič J. Do inhalational anesthetic agents still hold their place in modern anesthesia practice? Signa Vitae 2019; 15: 14–17. doi: 10.22514/SV152.092019.1 PotočnikI HostnikA Markovič-BožičJ Do inhalational anesthetic agents still hold their place in modern anesthesia practice? Signa Vitae 2019 15 14 17 10.22514/SV152.092019.1 Open DOISearch in Google Scholar

35. Markovic-Bozic J, Karpe B, Potocnik I, Jerin A, Vranic A, Novak-Jankovic V. Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy. BMC Anesthesiol 2016; 16: 18. doi: 10.1186/s12871-016-0182-5 Markovic-BozicJ KarpeB PotocnikI JerinA VranicA Novak-JankovicV Effect of propofol and sevoflurane on the inflammatory response of patients undergoing craniotomy BMC Anesthesiol 2016 16 18 10.1186/s12871-016-0182-5 Open DOISearch in Google Scholar

36. Jiao B, Yang C, Huang NN, Yang N, Jia Wei J, Xu H. Relationship between volatile anesthetics and tumor progression: unveiling the mystery. Curr Med Sci 2018; 38: 962–7. doi: 10.1007/s11596-018-1970-6 JiaoB YangC HuangNN YangN Jia WeiJ XuH Relationship between volatile anesthetics and tumor progression: unveiling the mystery Curr Med Sci 2018 38 962 7 10.1007/s11596-018-1970-6 Open DOISearch in Google Scholar

37. Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z. Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells. Br J Anaesth 2013; 110(Suppl 1): i82–91. doi: 10.1093/bja/aet115 ZhangL ZhangJ YangL DongY ZhangY XieZ Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells Br J Anaesth 2013 110 Suppl 1 i82 91 10.1093/bja/aet115 Open DOISearch in Google Scholar

38. Ulbrich F, Eisert L, Buerkle H, Goebel U, Schallner N. Propofol, but not keta-mine or midazolam, exerts neuroprotection after ischemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling. A combined in vitro study and animal study. Eur J Anaesthesiol 2016; 33: 670–80. doi: 10.1097/EJA.0000000000000449 UlbrichF EisertL BuerkleH GoebelU SchallnerN Propofol, but not keta-mine or midazolam, exerts neuroprotection after ischemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling. A combined in vitro study and animal study Eur J Anaesthesiol 2016 33 670 80 10.1097/EJA.0000000000000449 Open DOISearch in Google Scholar

39. Sun C, Liu P, Pei L, Zhao M, Huang Y. Propofol inhibits proliferation and augments the anti-tumor effect of doxorubicin and paclitaxel partly through promoting ferroptosis in triple-negative breast cancer cells. Front Oncol 2022; 12: 837974. doi: 10.3389/fonc.2022.837974 SunC LiuP PeiL ZhaoM HuangY Propofol inhibits proliferation and augments the anti-tumor effect of doxorubicin and paclitaxel partly through promoting ferroptosis in triple-negative breast cancer cells Front Oncol 2022 12 837974 10.3389/fonc.2022.837974 Open DOISearch in Google Scholar

40. El Azab SR, Rosseel PM, De Lange JJ, van Wijk EM, van Strik R, Scheffer GJ. Effect of VIMA with sevoflurane versus TIVA with propofol or midazolam-sufentanil on the cytokine response during CABG surgery. Eur J Anaesthesiol 2002; 19: 276–82. doi: 10.1017/s0265021502000443 El AzabSR RosseelPM De LangeJJ van WijkEM van StrikR SchefferGJ Effect of VIMA with sevoflurane versus TIVA with propofol or midazolam-sufentanil on the cytokine response during CABG surgery Eur J Anaesthesiol 2002 19 276 82 10.1017/s0265021502000443 Open DOISearch in Google Scholar

41. Minou AF, Dzyadzko AM, Shcherba AE, Rummo OO. The influence of pharmacological preconditioning with sevoflurane on incidence of early allograft dysfunction in liver transplant recipients. Anesthesiol Res Pract 2012; 2012: 930487. doi: 10.1155/2012/930487 MinouAF DzyadzkoAM ShcherbaAE RummoOO The influence of pharmacological preconditioning with sevoflurane on incidence of early allograft dysfunction in liver transplant recipients Anesthesiol Res Pract 2012 2012 930487 10.1155/2012/930487 Open DOISearch in Google Scholar

42. Jerin A, Pozar-Lukanovic N, Sojar V, Stanisavljevic D, Paver-Erzen V, Osredkar J. Balance of pro- and anti-inflammatory cytokines in liver surgery. Clin Chem Lab Med 2003; 41: 899–903. doi: 10.1515/CCLM.2003.136 JerinA Pozar-LukanovicN SojarV StanisavljevicD Paver-ErzenV OsredkarJ Balance of pro- and anti-inflammatory cytokines in liver surgery Clin Chem Lab Med 2003 41 899 903 10.1515/CCLM.2003.136 Open DOISearch in Google Scholar

43. Jabaudon M, Zhai R, Blondonnet R, Bonda WLM. Inhaled sedation in the intensive care unit. Anaesth Crit Care Pain Med 2022; 41: 101133. doi: 10.1016/j.accpm.2022.101133 JabaudonM ZhaiR BlondonnetR BondaWLM Inhaled sedation in the intensive care unit Anaesth Crit Care Pain Med 2022 41 101133 10.1016/j.accpm.2022.101133 Open DOISearch in Google Scholar

44. Song Z, Tan J. Effects of anesthesia and anesthetic techniques on metastasis of lung cancers: a narrative review. Cancer Manag Res 2022; 14: 189–204. doi: 10.2147/CMAR.S343772 SongZ TanJ Effects of anesthesia and anesthetic techniques on metastasis of lung cancers: a narrative review Cancer Manag Res 2022 14 189 204 10.2147/CMAR.S343772 Open DOISearch in Google Scholar

45. Oh CS, Park HJ, Piao L, Sohn KM, Koh SE, Hwang DY, et al. Expression profiles of immune cells after propofol or sevoflurane anesthesia for colorectal cancer surgery: a prospective double-blind randomized trial. Anesthesiology 2022; 136: 448–58. doi: 10.1097/ALN.0000000000004119 OhCS ParkHJ PiaoL SohnKM KohSE HwangDY Expression profiles of immune cells after propofol or sevoflurane anesthesia for colorectal cancer surgery: a prospective double-blind randomized trial Anesthesiology 2022 136 448 58 10.1097/ALN.0000000000004119 Open DOISearch in Google Scholar

46. Quan Y, Li S, Wang Y, Liu G, Lv Z, Wang Z. Propofol and sevoflurane alleviate malignant biological behavior and cisplatin resistance of Xuanwei lung adenocarcinoma by modulating the Wnt/β-catenin pathway and PI3K/AKT athway. Anticancer Agents Med Chem 2022; 22: 2098–2108. doi: 10.2174/1871520621666211026092405 QuanY LiS WangY LiuG LvZ WangZ Propofol and sevoflurane alleviate malignant biological behavior and cisplatin resistance of Xuanwei lung adenocarcinoma by modulating the Wnt/β-catenin pathway and PI3K/AKT athway Anticancer Agents Med Chem 2022 22 2098 2108 10.2174/1871520621666211026092405 Open DOISearch in Google Scholar

47. Yap A, Lopez-Olivo MA, Dubowitz J, Hiller J, Riedel B; Global Onco-Anesthesia Research Collaboration Group. Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia. Can J Anaesth 2019; 66: 546–61. doi: 10.1007/s12630-019-01330-x YapA Lopez-OlivoMA DubowitzJ HillerJ RiedelB Global Onco-Anesthesia Research Collaboration Group Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia Can J Anaesth 2019 66 546 61 10.1007/s12630-019-01330-x Open DOISearch in Google Scholar

48. Hovaguimian F, Braun J, Z’graggen BR, Schläpfer M, Dumrese C, Ewald C, et al. Anesthesia and circulating tumor cells in primary breast cancer patients: a randomized controlled trial. Anesthesiology 2020; 133: 548–58. doi: 10.1097/ALN.0000000000003409 HovaguimianF BraunJ Z’graggenBR SchläpferM DumreseC EwaldC Anesthesia and circulating tumor cells in primary breast cancer patients: a randomized controlled trial Anesthesiology 2020 133 548 58 10.1097/ALN.0000000000003409 Open DOISearch in Google Scholar

49. Buggy DJ, Riedel B, Sessler DI. Can anaesthetic technique influence cancer outcome? The next steps…. Br J Anaesth 2021; 127: 5–7. doi: 10.1016/j.bja.2021.04.005 BuggyDJ RiedelB SesslerDI Can anaesthetic technique influence cancer outcome? The next steps… Br J Anaesth 2021 127 5 7 10.1016/j.bja.2021.04.005 Open DOISearch in Google Scholar

50. Maalouf M, Reddy AJ, Mazboudi P, Min M, Rawal R, Curow CA, et al. An analysis of lidocaine usage in the treatment of squamous cell carcinoma. Cureus 2023; 15: e35614. doi: 10.7759/cureus.35614 MaaloufM ReddyAJ MazboudiP MinM RawalR CurowCA An analysis of lidocaine usage in the treatment of squamous cell carcinoma Cureus 2023 15 e35614 10.7759/cureus.35614 Open DOISearch in Google Scholar

51. Xing W, Chen DT, Pan JH, Chen YH, Yan Y, Li Q, et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology 2017; 126: 868–81. doi: 10.1097/ALN.0000000000001528 XingW ChenDT PanJH ChenYH YanY LiQ Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo Anesthesiology 2017 126 868 81 10.1097/ALN.0000000000001528 Open DOISearch in Google Scholar

52. Zhao L, Ma N, Liu G, Mao N, Chen F, Li J. Lidocaine inhibits hepatocellular carcinoma development by modulating circ_ITCH/miR-421/CPEB3 axis. Dig Dis Sci 2021; 66: 4384–97. doi: 10.1007/s10620-020-06787-1 ZhaoL MaN LiuG MaoN ChenF LiJ Lidocaine inhibits hepatocellular carcinoma development by modulating circ_ITCH/miR-421/CPEB3 axis Dig Dis Sci 2021 66 4384 97 10.1007/s10620-020-06787-1 Open DOISearch in Google Scholar

53. Zhang H, Yang L, Zhu X, Zhu M, Sun Z, Cata JP, et al. Association between intraoperative intravenous lidocaine infusion and survival in patients undergoing pancreatectomy for pancreatic cancer: a retrospective study. Br J Anaesth 2020; 125: 141–8. doi: 10.1016/j.bja.2020.03.034 ZhangH YangL ZhuX ZhuM SunZ CataJP Association between intraoperative intravenous lidocaine infusion and survival in patients undergoing pancreatectomy for pancreatic cancer: a retrospective study Br J Anaesth 2020 125 141 8 10.1016/j.bja.2020.03.034 Open DOISearch in Google Scholar

54. Diaz-Cambronero O, Mazzinari G, Cata JP. Perioperative opioids and colorectal cancer recurrence: a systematic review of the literature. Pain Manag 2018; 8: 353–61. doi: 10.2217/pmt-2018-0029 Diaz-CambroneroO MazzinariG CataJP Perioperative opioids and colorectal cancer recurrence: a systematic review of the literature Pain Manag 2018 8 353 61 10.2217/pmt-2018-0029 Open DOISearch in Google Scholar

55. Boudreau DM, Chen L, Yu O, Bowles EJA, Chubak J. Risk of second breast cancer events with chronic opioid use in breast cancer survivors. Pharmacoepidemiol Drug Saf 2019; 28: 740–53. doi: 10.1002/pds.4779 BoudreauDM ChenL YuO BowlesEJA ChubakJ Risk of second breast cancer events with chronic opioid use in breast cancer survivors Pharmacoepidemiol Drug Saf 2019 28 740 53 10.1002/pds.4779 Open DOISearch in Google Scholar

56. Shavit Y, Ben-Eliyahu S, Zeidel A, Beilin B. Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose timing study. Neuroimmunomodulation 2004; 11: 255–60. doi: 10.1159/000078444 ShavitY Ben-EliyahuS ZeidelA BeilinB Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose timing study Neuroimmunomodulation 2004 11 255 60 10.1159/000078444 Open DOISearch in Google Scholar

57. Saeed I, La Caze A, Hollmann MW, Shaw PN, Parat MO. New insights on tramadol and immunomodulation. Curr Oncol Rep 2021; 23: 123. doi: 10.1007/s11912-021-01121-y SaeedI La CazeA HollmannMW ShawPN ParatMO New insights on tramadol and immunomodulation Curr Oncol Rep 2021 23 123 10.1007/s11912-021-01121-y Open DOISearch in Google Scholar

58. Cata JP, Singh V, Lee BM, Villarreal J, Mehran JR, Yu J, et al. Intraoperative use of dexmedetomidine is associated with decreased overall survival after lung cancer surgery. J Anaesthesiol Clin Pharmacol 2017; 33: 317–23. doi: 10.4103/joacp.JOACP_299_16 CataJP SinghV LeeBM VillarrealJ MehranJR YuJ Intraoperative use of dexmedetomidine is associated with decreased overall survival after lung cancer surgery J Anaesthesiol Clin Pharmacol 2017 33 317 23 10.4103/joacp.JOACP_299_16 Open DOISearch in Google Scholar

59. Lavon H, Matzner P, Benbenishty A, Sorski L, Rossene E, Haldar R, et al. Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers. Br J Anaesth 2018; 120: 188–96. doi: 10.1016/j.bja.2017.11.004 LavonH MatznerP BenbenishtyA SorskiL RosseneE HaldarR Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancers Br J Anaesth 2018 120 188 96 10.1016/j.bja.2017.11.004 Open DOISearch in Google Scholar

60. Forget P, Berlière M, Poncelet A, De Kock M. Effect of clonidine on oncological outcomes after breast and lung cancer surgery. Br J Anaesth 2018; 121: 103–4. doi: 10.1016/j.bja.2018.04.020 ForgetP BerlièreM PonceletA De KockM Effect of clonidine on oncological outcomes after breast and lung cancer surgery Br J Anaesth 2018 121 103 4 10.1016/j.bja.2018.04.020 Open DOISearch in Google Scholar

61. Zhang Y, Li M, Cui E, Zhang H, Zhu X, Zhou J, et al. Dexmedetomidine attenuates sevoflurane induced neurocognitive impairment through α2 adrenoceptors. Mol Med Rep 2021; 23: 38. doi: 10.3892/mmr.2020.11676 ZhangY LiM CuiE ZhangH ZhuX ZhouJ Dexmedetomidine attenuates sevoflurane induced neurocognitive impairment through α2 adrenoceptors Mol Med Rep 2021 23 38 10.3892/mmr.2020.11676 Open DOISearch in Google Scholar

62. Zappavigna S, Cossu AM, Grimaldi A, Bocchetti M, Ferraro GA, Nicoletti GF, et al. Anti-inflammatory drugs as anticancer agents. Int J Mol Sci 2020; 21: 2605. doi: 10.3390/ijms21072605 ZappavignaS CossuAM GrimaldiA BocchettiM FerraroGA NicolettiGF Anti-inflammatory drugs as anticancer agents Int J Mol Sci 2020 21 2605 10.3390/ijms21072605 Open DOISearch in Google Scholar

63. Musselman RP, Bennett S, Li W, Mamdani M, Gomes T, van Walraven C, et al. Association between perioperative beta blocker use and cancer survival following surgical resection. Eur J Surg Oncol 2018; 44: 1164–69. doi: 10.1016/j.ejso.2018.05.012 MusselmanRP BennettS LiW MamdaniM GomesT van WalravenC Association between perioperative beta blocker use and cancer survival following surgical resection Eur J Surg Oncol 2018 44 1164 69 10.1016/j.ejso.2018.05.012 Open DOISearch in Google Scholar

64. Kalfeist L, Galland L, Ledys F, Ghiringhelli F, Limagne E, Ladoire S. Impact of glucocorticoid use in oncology in the immunotherapy era. Cells 2022; 11: 770. doi: 10.3390/cells11050770 KalfeistL GallandL LedysF GhiringhelliF LimagneE LadoireS Impact of glucocorticoid use in oncology in the immunotherapy era Cells 2022 11 770 10.3390/cells11050770 Open DOISearch in Google Scholar

65. Ristescu AI, Tiron CE, Tiron A, Grigoras I. Exploring hyperoxia effects in cancer-from perioperative clinical data to potential molecular mechanisms. Biomedicines 2021; 9: 1213. doi: 10.3390/biomedicines9091213 RistescuAI TironCE TironA GrigorasI Exploring hyperoxia effects in cancer-from perioperative clinical data to potential molecular mechanisms Biomedicines 2021 9 1213 10.3390/biomedicines9091213 Open DOISearch in Google Scholar