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Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67

Yanli Zhang

Yanli Zhang

Department of Clinical Pharmacy, Affiliated Hospital of Yangzhou UniversityYangzhou, China
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Zhang, Yanli
, 
Chao Ran

Chao Ran

Department of Radiology, Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai, China
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Ran, Chao
 e 
Wei Li

Wei Li

Department of Medical Imaging, Affiliated Hospital of Yangzhou UniversityYangzhou, China
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Li, Wei
  
04 set 2023
Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67's Cover Image
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Categoria dell'articolo: Research Article
Pubblicato online: 04 set 2023
Pagine: 310 - 316
Ricevuto: 28 apr 2023
Accettato: 21 lug 2023
DOI: https://doi.org/10.2478/raon-2023-0042
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© 2023 Yanli Zhang et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Background

This study aimed to evaluate the multi-phase CT findings of central and peripheral pulmonary sclerosing pneumocytomas (PSPs) and compared them with Ki-67 to reveal their neoplastic nature.

Patients and methods

Multi-phase CT and clinical data of 33 PSPs (15 central PSPs and 18 peripheral PSPs) were retrospectively analyzed and compared their multi-phase CT features and Ki-67 levels.

Results

For quantitative indicators, central PSPs were larger than peripheral PSPs (10.39 ± 3.25 cm3 vs. 4.65 ± 2.61 cm3, P = 0.013), and tumor size was negatively correlated with acceleration index (r = −0.845, P < 0.001). The peak enhancement of central PSPs appeared in the delayed phase, with a longer time to peak enhancement (TTP, 100.81 ± 19.01 s), lower acceleration index (0.63 ± 0.17), progressive enhancement, and higher Ki-67 level. The peak enhancement of peripheral PSPs appeared in the venous phase, with the shorter TTP (62.67 ± 20.96 s, P < 0.001), higher acceleration index (0.99 ± 0.25, P < 0.001), enhancement washout, and lower Ki-67 level. For qualitative indicators, the overlying vessel sign (86.67% vs. 44.44%, P = 0.027), prominent pulmonary artery sign (73.33% vs. 27.78%, P = 0.015), and obstructive inflammation/atelectasis (26.67% vs. 0%, P = 0.033) were more common in central PSPs, while peripheral PSPs were more common with halo sign (38.89% vs. 6.67%, P = 0.046).

Conclusions

The location of PSP is a possible contributing factor to its diverse imaging-pathological findings. The tumor size, multi-phase enhancement, qualitative signs, and Ki-67 were different between central and peripheral PSPs. Combined tumor size, multi-phase findings, and Ki-67 level are helpful to reveal the nature of the borderline tumor.
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicina, Medicina clinica, Medicina interna, Ematologia, Oncologia, Radiologia
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