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The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients

Zlatko Pravdic

Zlatko Pravdic

Clinic of Hematology, Clinical Center of SerbiaBelgrade, Serbia
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Pravdic, Zlatko
, 
Nada Suvajdzic Vukovic

Nada Suvajdzic Vukovic

  • Clinic of Hematology, Clinical Center of SerbiaBelgrade, Serbia
  • School of Medicine, University of BelgradeSerbia
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Vukovic, Nada Suvajdzic
, 
Vladimir Gasic

Vladimir Gasic

Institute of Molecular Genetics and Genetic Engineering, University of BelgradeSerbia
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Gasic, Vladimir
, 
Irena Marjanovic

Irena Marjanovic

Institute of Molecular Genetics and Genetic Engineering, University of BelgradeSerbia
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Marjanovic, Irena
, 
Teodora Karan-Djurasevic

Teodora Karan-Djurasevic

Institute of Molecular Genetics and Genetic Engineering, University of BelgradeSerbia
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Karan-Djurasevic, Teodora
, 
Sonja Pavlovic

Sonja Pavlovic

Institute of Molecular Genetics and Genetic Engineering, University of BelgradeSerbia
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Pavlovic, Sonja
 e 
Natasa Tosic

Natasa Tosic

Institute of Molecular Genetics and Genetic Engineering, University of BelgradeSerbia
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Tosic, Natasa
  
20 apr 2023
The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients's Cover Image
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Categoria dell'articolo: Research Article
Pubblicato online: 20 apr 2023
Pagine: 239 - 248
Ricevuto: 12 gen 2023
Accettato: 30 mar 2023
DOI: https://doi.org/10.2478/raon-2023-0017
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© 2023 Zlatko Pravdic et al., published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.

Background

Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment. Therefore, the gene expression profile of main apoptotic factors, such as anti-apoptotic BCL2 (B-cell lymphoma protein 2) and pro-apoptotic BAX (BCL2-associated X), as well as genes involved in the multi-drug resistance (ABCB1), could have significant impact on the prognosis and could be used as targets for specific therapy.

Patients and methods

We analyzed the expression of BCL2, BAX, and ABCB1 in bone-marrow samples collected at diagnosis from 51 adult patients with acute myeloid leukemia with normal karyotype (AML-NK) using real-time polymerase chain reaction method, and examined their prognostic potential.

Results

Increased expression of BCL2 (BCL2+) was associated with the presence of chemoresistance (p = 0.024), while patients with low BAX expression were more prone to relapse (p = 0.047). Analysis of the combined effect of BCL2 and BAX expression showed that 87% of patients with BAX/BCL2low status were resistant to therapy (p = 0.044). High expression of ABCB1 was associated with BCL2+ status (p < 0.001), and with absence FLT3-ITD mutations (p = 0.019).

Conclusions

The present analysis of BCL2, BAX, and ABCB1 gene expression profiles is the first study focusing solely on AML-NK patients. Preliminary results showed that patients with high BCL2 expression are likely to experience resistance to chemotherapy, and may benefit from specific anti-BCL2 treatment. Further investigations conducted on a larger number of patients could elucidate actual prognostic significance of these genes in AML-NK patients.
Lingua:
Inglese
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicina, Medicina clinica, Medicina interna, Ematologia, Oncologia, Radiologia
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