Crystalloids vs. colloids for fluid optimization in patients undergoing brain tumour surgery
Article Category: Research Article
Pubblicato online: 14 set 2022
Pagine: 508 - 514
Ricevuto: 22 feb 2022
Accettato: 05 lug 2022
DOI: https://doi.org/10.2478/raon-2022-0035
© 2022 Jasmina Markovic-Bozic, Bozidar Visocnik, Polona Music, Iztok Potocnik, Alenka Spindler Vesel, published by Sciendo
This work is licensed under the Creative Commons Attribution 4.0 International License.
Background
This randomised, double-blinded, single-centre study prospectively investigated the impact of goal directed therapy and fluid optimization with crystalloids or colloids on perioperative complications in patients undergoing brain tumour surgery. Main aim of the study was to investigate the impact of fluid type on postoperative complications.
Patients and methods
80 patients were allocated into two equal groups to be optimised with either crystalloids (n = 40) or colloids (n = 40). Invasive hemodynamic monitoring was used to adjust and maintain mean arterial pressure and cerebral oxygenation within the baseline values (± 20%) and stroke volume variation (SVV) ≤ 10%. Postoperative complications from different organ systems were monitored during the first 15 days after surgery. Hospital stay was also recorded.
Results
Crystalloid group received significantly more fluids (p = 0.003) and phenylephrine (p = 0.02) compared to colloid group. This did not have any significant impact on perioperative complications and hospital stay, since no differences between groups were observed.
Conclusions
Either crystalloids or colloids could be used for fluid optimization in brain tumour surgery. If protocolised perioperative haemodynamic management is used, the type of fluid does not have significant impact on the outcome.