This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer 1999; 83: 18-29. 10.1002/(sici)1097-0215(19990924)83:1<18::aid-ijc5>3.0.co;2-mPisaniPParkinDMBrayFFerlayJEstimates of the worldwide mortality from 25 cancers in 1990199983182910.1002/(sici)1097-0215(19990924)83:1<18::aid-ijc5>3.0.co;2-mOpen DOISearch in Google Scholar
Li J, Xu W, Liu F, Huang S, He M. GSTM1 polymorphism contribute to colorectal cancer in Asian populations: a prospective meta-analysis. Sci Rep 2015; 29: 12514. doi: 10.1038/srep12514LiJXuWLiuFHuangSHeMGSTM1 polymorphism contribute to colorectal cancer in Asian populations: a prospective meta-analysis2015291251410.1038/srep12514Open DOISearch in Google Scholar
Han JH, Lee HJ, Choi HJ, Yun KE, Kang MH. Lymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism. Nutr Re Pract 2017; 11: 214-22. doi: 10.4162/nrp.2017.11.3.214HanJHLeeHJChoiHJYunKEKangMHLymphocyte DNA damage and plasma antioxidant status in Korean subclinical hypertensive patients by glutathione S-transferase polymorphism2017112142210.4162/nrp.2017.11.3.214Open DOISearch in Google Scholar
Bellacosa A, Staal S, Tsichlis P. A retroviral oncogene, Akt, encoding a serinethreonine kinase containing an SH2-like region. Science 1991; 254: 274-77. doi: 10.1126/science.254.5029.274BellacosaAStaalSTsichlisPA retroviral oncogene, Akt, encoding a serinethreonine kinase containing an SH2-like region19912542747710.1126/science.254.5029.274Open DOISearch in Google Scholar
Martelli AM, Evangelisti C, Chiarini F, Grimaldi C, McCubrey JA. The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology. Cancers 2010; 2: 1576-96. doi: 10.3390/cancers2031576MartelliAMEvangelistiCChiariniFGrimaldiCMcCubreyJAThe emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology2010215769610.3390/cancers2031576Open DOISearch in Google Scholar
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74. doi: 10.1016/j.cell.2011.02.013HanahanDWeinbergRAHallmarks of cancer: the next generation20111446467410.1016/j.cell.2011.02.013Open DOISearch in Google Scholar
Zhi-Ze C. Berberine induced apoptosis of human osteosarcoma cells by inhibiting phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signal pathway activation. Iran J Public Health 2016; 45: 578-85. PMID: 27398330Zhi-ZeC.Berberine induced apoptosis of human osteosarcoma cells by inhibiting phosphoinositide 3 kinase/protein kinase B (PI3K/Akt) signal pathway activation20164557885PMID: 27398330Search in Google Scholar
Manning BD, Toker A. AKT/PKB signaling: navigating the network. Cell 2017; 169: 381-405. doi: 10.1016/j.cell.2017.04.001ManningBDTokerAAKT/PKB signaling: navigating the network201716938140510.1016/j.cell.2017.04.001Open DOISearch in Google Scholar
Wang L-q, He Y, Wan H-f, Zhou H-f, Yang J-h, Wan H-t. Protective mechanisms of hypaconitine and glycyrrhetinic acid compatibility in oxygen and glucose deprivation injury. J Zhejiang Univ Sci B 2017; 18: 586-96. doi: 10.1631/jzus.B1600270WangL-qHeYWanH-fZhouH-fYangJ-hWanH-tProtective mechanisms of hypaconitine and glycyrrhetinic acid compatibility in oxygen and glucose deprivation injury2017185869610.1631/jzus.B1600270Open DOISearch in Google Scholar
Minsu P, Choi HK, An JH. Taurine Activates BMP-2/Wnt3a-Mediated Osteoblast Differentiation and Mineralization via Akt and MAPK Signaling. Iran J Public Health 2019; 48: 1960-70. PMID: 31970094MinsuPChoiHKAnJHTaurine Activates BMP-2/Wnt3a-Mediated Osteoblast Differentiation and Mineralization via Akt and MAPK Signaling201948196070PMID: 31970094Search in Google Scholar
Kumar A, Rajendran V, Sethumadhavan R, Purohit R. AKT kinase pathway: a leading target in cancer research. Sci World J 2013; 2013: 1-6. doi: 10.1155/2013/756134KumarARajendranVSethumadhavanRPurohitRAKT kinase pathway: a leading target in cancer research201320131610.1155/2013/756134Open DOISearch in Google Scholar
Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. PNAS 2001; 98: 14967-72. doi: 10.1073/pnas.231467698MalstromSTiliEKappesDCeciJDTsichlisPNTumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus200198149677210.1073/pnas.231467698Open DOISearch in Google Scholar
Mende I, Malstrom S, Tsichlis PN, Vogt PK, Aoki M. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 2001; 20: 4419-23. doi: 10.1038/sj.onc.1204486MendeIMalstromSTsichlisPNVogtPKAokiMOncogenic transformation induced by membrane-targeted Akt2 and Akt320012044192310.1038/sj.onc.120448611466625Open DOISearch in Google Scholar
Ocana A, Vera-Badillo F, Al-Mubarak M, Templeton AJ., Corrales-Sanchez V, Diez-Gonzalez, et al. Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis. PLoS One 2014; 9: e95219. doi: 10.1371/journal.pone.0095219OcanaAVera-BadilloFAl-MubarakMTempletonAJ.Corrales-SanchezVDiez-Gonzalez, et alActivation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis20149e9521910.1371/journal.pone.0095219400243324777052Open DOISearch in Google Scholar
Xu J, Wang Z, Hu L, Yin Z, Huang M, Hu Z, et al. Genetic variants in the PI3K/ PTEN/Akt/mTOR pathway predict platinum-based chemotherapy response of advanced non-small cell lung cancers in a Chinese population. Asian Pacific J Cancer Prev 2012; 13: 2157-62. doi: 10.7314/apjcp.2012XuJWangZHuLYinZHuangMHuZet alGenetic variants in the PI3K/ PTEN/Akt/mTOR pathway predict platinum-based chemotherapy response of advanced non-small cell lung cancers in a Chinese population20121321576210.7314/apjcp.2012Open DOISearch in Google Scholar
Bizhani F, Hashemi M, Danesh H, Nouralizadeh A, Narouie B, Bahari G, et al. Association between single nucleotide polymorphisms in the PI3K/AKT/ mTOR pathway and bladder cancer risk in a sample of Iranian population. EXCLI J 2018; 2: 3-13. doi: 10.17179/excli2017-329BizhaniFHashemiMDaneshHNouralizadehANarouieBBahariGet alAssociation between single nucleotide polymorphisms in the PI3K/AKT/ mTOR pathway and bladder cancer risk in a sample of Iranian population2018231310.17179/excli2017-329578062829383014Open DOISearch in Google Scholar
Imran M, Park TJ, Lim IK. TIS21/BTG2/PC3 enhances downregulation of c-Myc during differentiation of HL-60 cells by activating Erk1/2 and inhibiting Akt in response to all-trans-retinoic acid. Eur J Cancer 2012; 48: 2474-85. doi: 10.1016/j.ejca.2012.01.028ImranMParkTJLimIKTIS21/BTG2/PC3 enhances downregulation of c-Myc during differentiation of HL-60 cells by activating Erk1/2 and inhibiting Akt in response to all-trans-retinoic acid20124824748510.1016/j.ejca.2012.01.02822341854Open DOISearch in Google Scholar
Imran M, Lim IK. Regulation of BTG2/TIS21/PC3 expression via reactive oxygen species-protein kinase C-ΝFκΒ pathway under stress conditions. Cell Signal 2013; 25: 2400-12. doi: 10.1016/j.cellsig.2013.07.015.ImranMLimIKRegulation of BTG2/TIS21/PC3 expression via reactive oxygen species-protein kinase C-ΝFκΒ pathway under stress conditions20132524001210.1016/j.cellsig.2013.07.01523876794Open DOISearch in Google Scholar
Imran M, Park JS, Lim IK. Stress-induced NF-κB activation differentiates promyelocytic leukemia cells to macrophages in response to all-trans-retinoic acid. Cell Signal 2015; 27: 694-706. doi: 10.1016/j.cellsig.2014.11.019ImranMParkJSLimIKStress-induced NF-κB activation differentiates promyelocytic leukemia cells to macrophages in response to all-trans-retinoic acid20152769470610.1016/j.cellsig.2014.11.01925435432Open DOISearch in Google Scholar
Zubair H, Lim IK, Safi SZ, Rehman F, Imran M. Akt downregulates B-cell translocation gene-2 expression via Erk1/2 inhibition for proliferation of cancer cells. Ann Clin Lab Sci 2020; 50: 711-16. PMID: 33334784ZubairHLimIKSafiSZRehmanFImranMAkt downregulates B-cell translocation gene-2 expression via Erk1/2 inhibition for proliferation of cancer cells20205071116PMID: 33334784Search in Google Scholar
Gul S, Khisroon M, Khan A, Gul S, Khan G N. Assessment of genotoxicity in lymphocytes of active and passive cigarette smokers attenuated with green tea. Pak J Zool 2019; 51: 1131-36. doi: 10.17582/journal.pjz/2019.51.3.1131.1136GulSKhisroonMKhanAGulSKhanG NAssessment of genotoxicity in lymphocytes of active and passive cigarette smokers attenuated with green tea20195111313610.17582/journal.pjz/2019.51.3.1131.1136Open DOISearch in Google Scholar
Singh NP, McCoy MT, Tice R.R, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-91. doi: 10.1016/0014-4827(88)90265-0SinghNPMcCoyMTTiceR.RSchneiderELA simple technique for quantitation of low levels of DNA damage in individual cells19881751849110.1016/0014-4827(88)90265-03345800Open DOISearch in Google Scholar
Zhang Z, Chen Q, Zhang J, Wang Y, Hu X, Yin S, et al. Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: a meta-analysis in Asian population. Sci Rep 2017; 7: 1-11. doi: 10.1038/s41598-017-17250-zZhangZChenQZhangJWangYHuXYinSet alAssociations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: a meta-analysis in Asian population2017711110.1038/s41598-017-17250-z573673229259266Open DOISearch in Google Scholar
Schwingshackl L, Schwedhelm C, Hoffmann G, Knuppel S, Preterre AL, Iqbal K, et al. Food groups and risk of colorectal cancer. Int. J. Cancer 2018; 142: 1748-58. doi: 10.1002/ijc.31198SchwingshacklLSchwedhelmCHoffmannGKnuppelSPreterreALIqbalKet alFood groups and risk of colorectal cancer201814217485810.1002/ijc.3119829210053Open DOISearch in Google Scholar
Xu W, Ni Z, Zhang M, Chen J, Zhang L, Wu S, et al. The role of polymorphisms in genes of PI3K/Akt signaling pathway on prostate. J Cancer 2019; 10: 102331. doi: 10.7150/jca.26472XuWNiZZhangMChenJZhangLWuSet alThe role of polymorphisms in genes of PI3K/Akt signaling pathway on prostate20191010233110.7150/jca.26472640080030854108Open DOISearch in Google Scholar
Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Sugimura H, et al. Association between AKT1 gene polymorphism rs2498794 and smoking-related traits with reference to cancer susceptibility. Biomed Res Int 2015; 2015: 316829. doi: 10.1155/2015/316829NishizawaDKasaiSHasegawaJSatoNTaniokaFSugimuraHet alAssociation between AKT1 gene polymorphism rs2498794 and smoking-related traits with reference to cancer susceptibility2015201531682910.1155/2015/316829447556026137473Open DOISearch in Google Scholar
Avan A, Avan A, Large TYSL, Mambrini A, Funel N, Maftouh M, et al. AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients. PLoS One 2014; 9: e108057. doi: 10.1371/journal.pone.0108057AvanAAvanALargeTYSLMambriniAFunelNMaftouhMet alAKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients20149e10805710.1371/journal.pone.0108057416959525238546Open DOISearch in Google Scholar
Li Y, Zhu L, Yao H, Zhang Y, Kong X, Chen L, et al. Association of inflammation-related gene polymorphisms with susceptibility and radiotherapy sensitivity in head and neck squamous cell carcinoma patients in northeast China. Front Oncol 2021; 11: 651632. doi: 10.3389/fonc.2021.651632LiYZhuLYaoHZhangYKongXChenLet alAssociation of inflammation-related gene polymorphisms with susceptibility and radiotherapy sensitivity in head and neck squamous cell carcinoma patients in northeast China20211165163210.3389/fonc.2021.651632821281434150619Open DOISearch in Google Scholar
Giovannetti E, Zucali PA, Peters GJ, Cortesi F, D’Incecco A, Smit EF, et al. Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non–small cell lung cancer patients treated with gefitinib. Mol Cancer Ther 2010 9: 581-93. doi: 10.1158/1535-7163GiovannettiEZucaliPAPetersGJCortesiFD’InceccoASmitEFet alAssociation of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non–small cell lung cancer patients treated with gefitinib201095819310.1158/1535-7163Open DOISearch in Google Scholar
Blest-Hopley G, Colizzi M, Prata D. Giampietro V, Brammer M, McGuire P, et al. Epigenetic mediation of AKT1 rs1130233’s effect on delta-9-tetrahydrocannabinol-induced medial temporal function during fear processing. Brain Sci 2021; 11: 1240, doi: 10.3390/brainsci11091240Blest-HopleyGColizziMPrataDGiampietroVBrammerMMcGuirePet alEpigenetic mediation of AKT1 rs1130233’s effect on delta-9-tetrahydrocannabinol-induced medial temporal function during fear processing202111124010.3390/brainsci11091240847166534573260Open DOISearch in Google Scholar
Piao Y, Li Y, Xu Q, Liu J-w, Xing C-z, Xie X-d, et al. Association of MTOR and AKT gene polymorphisms with susceptibility and survival of gastric cancer. PLOS ONE 2015; 10: e0136447. doi: 10.1371/journal.pone.0136447PiaoYLiYXuQLiuJ-wXingC-zXieX-det alAssociation of MTOR and AKT gene polymorphisms with susceptibility and survival of gastric cancer201510e013644710.1371/journal.pone.0136447455286926317520Open DOISearch in Google Scholar
Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R, et al. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Investig 2008; 118: 2200-08. doi: 10.1172/JCI34725TanHYNicodemusKKChenQLiZBrookeJKHoneaRet alGenetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans200811822000810.1172/JCI34725239127918497887Open DOISearch in Google Scholar
Piscitello D, Varshney D, Lilla S, Vizioli MG, Reid C, Gorbunova V, et al AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. Oncogene 2018; 37: 427-38. doi: 10.1038/onc.2017.340PiscitelloDVarshneyDLillaSVizioliMGReidCGorbunovaVet alAKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE112018374273810.1038/onc.2017.340579971628967905Open DOISearch in Google Scholar
Gol MT, Rodemann, HP, Dittmann K. Depletion of Akt1 and Akt2 impairs the repair of radiation-induced DNA double strand breaks via homologous recombination. Int J Mol Sci 2019; 20: 6316. doi: 10.3390/ijms20246316GolMTHPRodemannDittmannKDepletion of Akt1 and Akt2 impairs the repair of radiation-induced DNA double strand breaks via homologous recombination201920631610.3390/ijms20246316694106331847370Open DOISearch in Google Scholar
Hers I, Vincent EE, Tavaré JM. Akt signalling in health and disease. Cell Signal 2011; 23:1515-27. doi: 10.1016/j.cellsig.2011.05.004HersIVincentEETavaréJMAkt signalling in health and disease20112315152710.1016/j.cellsig.2011.05.00421620960Open DOISearch in Google Scholar
Cortes U, Moyret-Lalle C, Falette N, Guillot C, Rimokh R, Wang Q, et al. BTG gene expression in the p53-dependent and -independent cellular response to DNA damage. Mol Carcinog 2000; 27: 57-64. doi: 10.1038/ng1296-482CortesUMoyret-LalleCFaletteNGuillotCRimokhRWangQet alBTG gene expression in the p53-dependent and -independent cellular response to DNA damage200027576410.1038/ng1296-4828944033Open DOISearch in Google Scholar