Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging
, , , , , , e | 04 mag 2022
INFORMAZIONI SU QUESTO ARTICOLO
Article Category: Research Article
Pubblicato online: 04 mag 2022
Pagine: 150 - 155
Ricevuto: 02 dic 2021
Accettato: 18 mar 2022
DOI: https://doi.org/10.2478/raon-2022-0017
© 2022 Sinem Aydin, Tarik Demir, Haci Mehmet Turk, Dilek Hacer Cesme, Altay Aliyev, Mehmet Ali Gultekin, Temel Fatih Yilmaz, Alpay Alkan, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1
Fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD) and radial diffusivity (RD) values of the defined regions of interest in the patients with non-small cell lung cancer (NSCLC) and the control group
| Regions of interest | NSCLC patients (n = 25) | Control (n = 27) | ||||||
|---|---|---|---|---|---|---|---|---|
| FA | AD | MD | RD | FA | AD | MD | RD | |
| R ILF | 591.86±74.62 | 1500.75±122.17 | 863.76±65.15 | 545.27±96.29 | 575.66±79.55 | 1458.45±131.20 | 843.76±76.46 | 536.41±93.74 |
| L ILF | 600.06±59.94 | 1529.15±173.76 | 868.6±97.02 | 538.32±103.53 | 613.26±80.83 | 1543.02±136.96 | 856.6±105.47 | 513.38±125.10 |
| R SLF | 558.53±114.37 | 1299.28±201.73 | 754.18±67.60 | 481.63±88.42 | 595.02±87.69 | 1411.18±141.51 | 792.77±46.74 | 483.57±74.45 |
| L SLF | 532.01±118.55 | 1299.01±173.29 | 778.50±71.55 | 518.24±110.51 | 591.15±96.81 | 1416±149.16 | 795.97±59.44 | 485.95±82.96 |
| R FM | 554.53±100.65 | 1338.19±156.48 | 769.57±105.53 | 512.13±99.98 | 629.28±151.29 | 1508.51±288.33 | 813.40±80.35 | 465.84±139.28 |
| L FM | 507.28±109.36 | 1307.52±188.16 | 807.18±63.09 | 557.02±109.36 | 653.10±173.43 | 1605.51±322.02 | 836.1±86.54 | 451.52±168.22 |
| R ATR | 340.74±88.42 | 1103.33±81.11 | 808.82±52.68 | 661.56±75.32 | 356.29±93.06 | 1079.83±101.61 | 785.80±60.54 | 638.79±74.98 |
| L ATR | 346.5±80.36 | 1106.73±129.93 | 787.19±107.16 | 654.76±99.75 | 370.34±99.10 | 1106.84±127.16 | 795.80±78.49 | 640.28±91.63 |
| R ACR | 462.64±165.21 | 1257.80±260.67 | 796.58±212.71 | 593.33±239.64 | 474.52±112.45 | 1189.22±123.22 | 766.57±64.26 | 555.24±93.58 |
| L ACR | 426.54±118.96 | 1132.28±137.42 | 771.2±75.36 | 590.67±106.29 | 493.42±113.02 | 1204.54±150.69 | 762.29±68.51 | 541.17±86 |
| R EC | 421.5±103.19 | 1186.76±131.98 | 801.44±49.57 | 608.78±75.25 | 467.90±76.67 | 1206.38±142.25 | 785.90±67.27 | 575.67±66.99 |
| L EC | 473.82±92.65 | 1207.59±112.50 | 775.09±67.91 | 558.84±93.05 | 496.03±82.19 | 1220.38±150.32 | 766.20±69.01 | 539.11±75.26 |
| R IFOF | 492.68±71.61 | 1265.71±107.18 | 790.68±68.32 | 553.16±80.63 | 518.93±69.64 | 1319.51±149.14 | 803.93±64.48 | 546.14±61.75 |
| L IFOF | 475.18±85.00 | 1235.06±108.44 | 786.80±56.69 | 562.67±77.186 | 492.90±88.55 | 1305.21±143.83 | 817.78±68.26 | 574.07±80.16 |
| G CC | 805.78±79.27 | 1773.6±231.49 | 799.20±135.38 | 312±138.14 | 792.98±56.11 | 1810.47±167.43 | 822.28±72.58 | 328.19±75.54 |
| S CC | 806.87±83.00 | 1862.29±206.96 | 832.26±115.01 | 317.24±143.53 | 845.36±49.03 | 1823.75±243.74 | 775.42±113.42 | 251.25±81.05 |
| R FWM | 383.34±89.30 | 1171.85±148.03 | 822.22±66.41 | 647.41±81.58 | 388.92±109.23 | 1137.18±106.56 | 798.74±61.26 | 629.51±98.77 |
| L FWM | 377.06±89.53 | 1143.71±126.45 | 810.22±55.30 | 643.47±69.93 | 399.48±116.43 | 1147.24±114.15 | 798.29±78.91 | 623.81±114.37 |
| R POWM | 353.36±76.49 | 1155.84±130.45 | 837.16±70.62 | 677.82±70.49 | 394.78±91.19 | 1182.94±193.23 | 818.38±108.45 | 636.1±103.87 |
| L POWM | 344.49±75.64 | 1142.25±122.83 | 834.81±74.07 | 681.09±75.55 | 388.00±89.02 | 1254.38±148.62 | 871.37±93.75 | 679.86±102.15 |
Comparison of diffusion tensor imaging (DTI) values of the defined anatomic locations before and after chemotherapy (the significant results are in italics)
| Group 1 (n:7) | Group 2 (n:18) | ||||||
|---|---|---|---|---|---|---|---|
| Region of interest | Pre-chemotherapy values (Median (min-max)) | Post-chemotherapy values (Median (min-max)) | Regions of interest | Pre-chemotherapy values (Median (min-max) | Post-chemotherapy values (Median (min-max) | ||
| R ILF FA | 623 (514–703.3) | 522 (418.7–679.8) | R ILF FA | 600 (395.3–694.5) | 593 (336–707) | 0.89 | |
| R FM FA | 539 (448–591) | 471 (379.7–615.8) | 0.31 | R FM FA | 525 (454.5–864) | 487 (322.3–712) | |
| R FM RD | 487.4 (465.5–605.65) | 619.4 (439.5–667.85) | 0.062 | R FM RD | 533.275 (201–689) | 580.35 (367.8–819.15) | |
| R FWM AD | 1123.5 (912.8–1244) | 1135.5 (988.3–1265.5) | 0.39 | R FWM AD | 1157.65 (1011.3–1556.5) | 1104.15 (854.8–1256.3) | |
| R FWM MD | 786.1 (699.1–871.26) | 823.26 (658.93–855.1) | 0.31 | R FWM MD | 793.01 (658.2–955.36) | 812.33(704.53–1006.9) | |
Comparison of the diffusion tensor imaging (DTI) results of the two chemotherapy regimens on the defined anatomic locations (only the significant results are shown)
| Region of interest | Cisplatin | Carboplatin | |
|---|---|---|---|
| Left POWM FA | 389 (273.3–531) | 319 (167.3–423) | 0.034 |
| Left POWM MD | 767.6 (727.53–925.27) | 837.13 (737.2–1071.77) | 0.034 |
| Left POWM RD | 606.1 (507.9–726.65) | 705.92 (592.80–905.15) | 0.029 |