<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0062_s_006_w2aab3b7ab1b6b1aab1c16b1Aa"><h3>Background</h3><p>Higher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O±A±T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters.</p></sec><sec id="j_raon-2020-0062_s_007_w2aab3b7ab1b6b1aab1c16b2Aa"><h3>Patients and methods</h3><p>In a randomized double-blind trial, 80 men with O±A±T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured.</p></sec><sec id="j_raon-2020-0062_s_008_w2aab3b7ab1b6b1aab1c16b3Aa"><h3>Results</h3><p>Analysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondrial membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined.</p></sec><sec id="j_raon-2020-0062_s_009_w2aab3b7ab1b6b1aab1c16b4Aa"><h3>Conclusions</h3><p>The oral intake of astaxanthin did not affect any semen parameters in patients with O±A±T.</p></sec></abstract>

BackgroundHigher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an impact on the prevention and treatment of various health conditions, including cancer. However, efficacy studies on astaxanthin in patients with oligospermia with/without astheno- or teratozoospermia (O±A±T) have not yet been reported. Our aim was to evaluate the effect of the oral intake of astaxanthin on semen parameters.Patients and methodsIn a randomized double-blind trial, 80 men with O±A±T were allocated to intervention with 16 mg astaxanthin orally daily or placebo. At baseline and after three months basic semen parameters, sperm deoxyribonucleic acid (DNA) fragmentation and mitochondrial membrane potential (MMP) of spermatozoa and serum follicle-stimulating hormone (FSH) value were measured.ResultsAnalysis of the results of 72 patients completing the study (37 in the study group, 35 in the placebo group) did not show any statistically significant change, in the astaxanthin group no improvements in the total number of spermatozoa, concentration of spermatozoa, total motility of spermatozoa, morphology of spermatozoa, DNA fragmentation and mitochondrial membrane potential of spermatozoa or serum FSH were determined. In the placebo group, statistically significant changes in the total number and concentration of spermatozoa were determined.ConclusionsThe oral intake of astaxanthin did not affect any semen parameters in patients with O±A±T.

Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial

Radiology and Oncology

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BackgroundHigher concentrations of seminal reactive oxygen species may be related to male infertility. Astaxanthin with high antioxidant activity can have an...

Effect of the oral intake of astaxanthin on semen parameters in patients with oligo-astheno-teratozoospermia: a randomized double-blind placebo-controlled trial

Article Category: Research Article

Pubblicato online: 23 ott 2020

Pagine: 97 - 105

Ricevuto: 17 ago 2020

Accettato: 14 set 2020

DOI: https://doi.org/10.2478/raon-2020-0062

© 2021 Senka Imamovic Kumalic, Irma Virant Klun, Eda Vrtacnik Bokal, Bojana Pinter, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.