Characteristics | All | EGFR-wt | EGFR-m | |||
---|---|---|---|---|---|---|
n | n | (%) | n | (%) | p | |
355 | 266 | 75 | 89 | 25 | ||
median | 64.4 | 63.5 | 65.6 | 65.6 | 0.98 | |
range | 25-88 | 25–87 | 25–87 | 36–88 | ||
female | 165 | 107 | 40.2 | 58 | 65.2 | < 0.001 |
male | 190 | 159 | 59.8 | 31 | 34.8 | |
< 0.001 | ||||||
current | 142 | 132 | 49.6 | 10 | 11.2 | |
former | 101 | 81 | 30.5 | 20 | 22.5 | |
never | 95 | 40 | 15.0 | 55 | 61.8 | |
unknown | 17 | 13 | 4.9 | 4 | 4.5 | |
adenocarcinoma | 309 | 232 | 87.2 | 77 | 86.2 | 0.86 |
non-small cell lungcancer, NOS | 46 | 34 | 12.8 | 12 | 13.5 | |
Brain | 86 | 61 | 22.9 | 25 | 28.1 | 0.33 |
Bone | 151 | 104 | 39.1 | 47 | 52.8 | 0.02 |
Lung | 157 | 106 | 39.8 | 51 | 57.3 | 0.01 |
Pleura | 115 | 83 | 31.2 | 32 | 36.0 | 0.48 |
Liver | 55 | 40 | 15.0 | 15 | 16.9 | 0.68 |
Adrenal gland | 49 | 43 | 16.2 | 6 | 6.7 | 0.02 |
Distant lymph nodes | 55 | 46 | 17.3 | 9 | 10.1 | 0.10 |
Other sites | 40 | 34 | 12.8 | 6 | 6.7 | 0.11 |
Metastatic site | Patients | mOS | |||
---|---|---|---|---|---|
n | all | EGFR-m | EGFR-wt | p | |
Brain | 86 | 8.1 | 14.9 | 7.1 | |
Bone | 151 | 9.4 | 21.3 | 6.7 | |
Lung | 157 | 11.9 | 20.2 | 8.3 | |
Pleura | 115 | 8.8 | 20.6 | 6.5 | |
Liver | 55 | 5.6 | 10.4 | 5.5 | 0.245 |
Adrenal gland | 49 | 5.2 | 4.9 | 5.5 | 0.595 |
Distant lymph nodes | 55 | 6.2 | 13.0 | 5.5 | 0.237 |
Other sites | 40 | 8.9 | 14.9 | 8.4 | 0.156 |
7th TNM classification | ||||||
---|---|---|---|---|---|---|
M descriptor | EGFR-m | EGFR-wt | ||||
n | n | mOS | n | mOS | p | |
M1a | 78 | 17 | 22.4 | 61 | 10.7 | 0.025 |
M1b | 252 | 72 | 18.8 | 205 | 7.9 | < 0.001 |
All | 355 | 89 | 20.6 | 266 | 8.3 | < 0.001 |
M1a | 78 | 17 | 22.4 | 61 | 10.7 | 0.025 |
M1b | 37 | 5 | 39.2 | 32 | 14.4 | 0.082 |
M1c | 240 | 67 | 18.8 | 173 | 6.6 | < 0.001 |
All | 355 | 89 | 20.6 | 266 | 8.3 | < 0.001 |
Metastatic sites (old M1b only) | all | EGFR-m | EGFR-wt | p | ||
---|---|---|---|---|---|---|
n | n | mOS | n | mOS | ||
Single organ | 72 | 14 | 32.5 | 58 | 11.5 | < 0.001 |
Multiple organs | 205 | 58 | 17.4 | 147 | 6.1 | < 0.001 |
All | 277 | 77 | 20.5 | 205 | 7.8 | < 0.001 |