<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2019-0022_s_006_w2aab3b7b9b1b6b1aab1c18b1Aa"><h3>Background</h3><p>Diabetes mellitus (DM) and DM related comorbidities may initiate difficulties during cancer specific treatment and may have an impact on cancer management and outcome. The aim of our study was to find out if DM in patients with advanced colorectal carcinoma (CRC) is associated with cancer-specific or overall survival.</p></sec><sec id="j_raon-2019-0022_s_007_w2aab3b7b9b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>This study included 200 consecutive patients (131 males, 69 females, mean age 63 years) with elective CRC surgery at the Institute of Oncology Ljubljana and DM was found in 39 (19.5%) of them. Even 64% of patients had Stage 3 or 4 disease, so neo-adjuvant chemotherapy (CTX) and/or radiotherapy (RT) were carried out in 59% of cases. Data about gender, age, body mass index, presence of DM, American Society of Anesthesiologists (ASA) physical status score, stage of disease and postoperative complications were collected prospectively. Cancer-specific survival and overall survival were compared by log-rank test.</p></sec><sec id="j_raon-2019-0022_s_008_w2aab3b7b9b1b6b1aab1c18b3Aa"><h3>Results</h3><p>Patients with DM had a higher ASA score, BMI, the illness marker, rate of massive bleeding, blood transfusion and longer hospital stay than those without DM. The mean follow-up period was 4.75 years. All causes mortality in patients with DM and without DM was 23% and 27%, respectively. Three-year cancer-specific survival in patients with DM and without DM was 85% and 89%, respectively (p = 0.68). Three-year overall survival in patients with DM and without DM was 82% and 84%, respectively (p = 0.63).</p></sec><sec id="j_raon-2019-0022_s_009_w2aab3b7b9b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>The presence of DM was not associated with tumor stage, disease-specific survival or overall survival in patients with advanced CRC.</p></sec></abstract>

BackgroundDiabetes mellitus (DM) and DM related comorbidities may initiate difficulties during cancer specific treatment and may have an impact on cancer management and outcome. The aim of our study was to find out if DM in patients with advanced colorectal carcinoma (CRC) is associated with cancer-specific or overall survival.Patients and methodsThis study included 200 consecutive patients (131 males, 69 females, mean age 63 years) with elective CRC surgery at the Institute of Oncology Ljubljana and DM was found in 39 (19.5%) of them. Even 64% of patients had Stage 3 or 4 disease, so neo-adjuvant chemotherapy (CTX) and/or radiotherapy (RT) were carried out in 59% of cases. Data about gender, age, body mass index, presence of DM, American Society of Anesthesiologists (ASA) physical status score, stage of disease and postoperative complications were collected prospectively. Cancer-specific survival and overall survival were compared by log-rank test.ResultsPatients with DM had a higher ASA score, BMI, the illness marker, rate of massive bleeding, blood transfusion and longer hospital stay than those without DM. The mean follow-up period was 4.75 years. All causes mortality in patients with DM and without DM was 23% and 27%, respectively. Three-year cancer-specific survival in patients with DM and without DM was 85% and 89%, respectively (p = 0.68). Three-year overall survival in patients with DM and without DM was 82% and 84%, respectively (p = 0.63).ConclusionsThe presence of DM was not associated with tumor stage, disease-specific survival or overall survival in patients with advanced CRC.

Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus – a single institution experience

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundDiabetes mellitus (DM) and DM related comorbidities may initiate difficulties during cancer specific treatment and may have an impact on cancer...

Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus – a single institution experience

Article Category: Research Article

Pubblicato online: 08 mag 2019

Pagine: 238 - 244

Ricevuto: 31 gen 2019

Accettato: 07 apr 2019

DOI: https://doi.org/10.2478/raon-2019-0022

© 2019 Nikola Besic, Milena Kerin Povsic, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.