<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2018-0025_s_006_w2aab3b7b2b1b6b1aab1c18b1Aa"><h3>Background</h3><p>We assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme.</p></sec><sec id="j_raon-2018-0025_s_007_w2aab3b7b2b1b6b1aab1c18b2Aa"><h3>Patients and methods</h3><p>The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity.</p></sec><sec id="j_raon-2018-0025_s_008_w2aab3b7b2b1b6b1aab1c18b3Aa"><h3>Results</h3><p>Among 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p &lt; 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p &lt; 0.001), and in right hemicolon (p &lt; 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%.</p></sec><sec id="j_raon-2018-0025_s_009_w2aab3b7b2b1b6b1aab1c18b4Aa"><h3>Conclusions</h3><p>Interval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.</p></sec></abstract>

BackgroundWe assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme.Patients and methodsThe analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity.ResultsAmong 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%.ConclusionsInterval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.

Interval cancers after negative immunochemical test compared to screen and non-responders’ detected cancers in Slovenian colorectal cancer screening programme

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundWe assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity...

		Screen detected cancer (SDC)		Interval cancer (IC)		Non-responders cancer (NRC)		p value (SDC vs IC)	p value (IC vs NRC)	p value (SDC vs NRC)

		Number	%	Number	%	Number	%
Cancer total		493		79		395
Age	50-54	89	18.1	12	15.2	73	18.5	0.101	0.323	0.119
	55-59	93	18.9	10	12.7	63	15.9
	60-64	182	36.9	26	32.9	145	36.7
	65 ≤	129	26.2	31	39.2	114	28.9
Gender	Male	308	62.5	50	63.3	271	68.6	0.889	0.356	0.057
Gender	Female	185	37.5	29	36.7	124	31.4	0.889	0.356	0.057
Years of schooling	≤ 9 years	146	29.6	14	17.7	160	40.5	0.029	< 0.001	0.001
	≥ 10 years	342	69.4	64	81.0	230	58.2
	Unknown	5	1.0	1	1.3	5	1.3
Cancer site	Distal colon	380	77.1	39	49.4	301	76.2	< 0.001	< 0.001	0.759
Cancer site	Proximal colon	113	22.9	40	50.6	94	23.8	< 0.001	< 0.001	0.759
TNM stage	I	251	50.9	16	20.3	32	8.1	< 0.001	0.023	< 0.001
	II	99	20.1	17	21.5	87	22.0
	III	104	21.1	25	31.6	124	31.4
	IV	39	7.9	19	24.1	132	33.4
	Unknown	0		2	2.5	20	5.1

Interval cancers after negative immunochemical test compared to screen and non-responders’ detected cancers in Slovenian colorectal cancer screening programme

Article Category: Research Article

Pubblicato online: 12 lug 2018

Pagine: 413 - 421

Ricevuto: 17 apr 2018

Accettato: 20 mag 2018

DOI: https://doi.org/10.2478/raon-2018-0025

© 2018 Dominika Novak Mlakar, Tatjana Kofol Bric, Ana Lucija Škrjanec, Mateja Krajc, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Figure 2

Selected characteristics of colorectal cancer patients and their disease