The influence of genetic variability on the risk of developing malignant mesothelioma
, , , , e | 24 gen 2018
INFORMAZIONI SU QUESTO ARTICOLO
Article Category: Research Article
Pubblicato online: 24 gen 2018
Pagine: 105 - 111
Ricevuto: 03 set 2017
Accettato: 12 set 2017
DOI: https://doi.org/10.2478/raon-2018-0004
© 2018 Alenka Franko, Nika Kotnik, Katja Goricar, Viljem Kovac, Metoda Dodic-Fikfak, Vita Dolzan
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The distribution of antioxidative and repair gene polymorphisms in MM patients and controls and risk of MM
| Polymorphism | Genotype | MM patients | Controls | Unadjusted risk | Adjusted by age | Adjusted by smoking | Adjusted by abestos exposure | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
| CC | 98 (62.0) | 82 (73.9) | ||||||||||
missing data for 10 patients | CT | 57 (36.1) | 27 (24.3) | 1.63 | 0.103 | 1.72 | 0.124 | |||||
| TT | 3 (1.9) | 2 (1.8) | (0.91–2.95) | (0.83–3.57) | ||||||||
| CC | 79 (50.0) | 70 (57.4) | ||||||||||
| CT | 64 (40.5) | 47 (38.5) | 1.35 | 0.220 | 1.21 | 0.484 | 1.47 | 0.159 | 1.45 | 0.288 | ||
| TT | 15 (9.5) | 5 (4.1) | (0.84–2.17) | (0.71–2.05) | (0.86–2.51) | (0.73–2.88) | ||||||
| CC | 44 (27.7) | 31 (25.8) | ||||||||||
missing data for 2 patients | CT | 81 (50.9) | 52 (43.3) | 0.89 | 0.661 | 0.76 | 0.371 | 0.95 | 0.857 | 0.81 | 0.578 | |
| TT | 31 (19.5) | 37 (30.8) | (0.52–1.52) | (0.41–1.39) | (0.52–1.73) | (0.38–1.73) | ||||||
| CC | 99 (62.3) | 82 (70.1) | ||||||||||
missing data for 4 patients | CG | 52 (32.7) | 32 (27.4) | 1.37 | 0.225 | 1.42 | 0.232 | 1.36 | 0.286 | 1.77 | 0.125 | |
| GG | 6 (3.8) | 3 (2.6) | (0.82–2.29) | (0.80–0.51) | (0.77–2.41) | (0.85–3.66) | ||||||
Clinical characteristics of MM patients and controls
| Controls (n = 122) | MM patients (n = 159) | Test | p | |
|---|---|---|---|---|
| Gender N (%) | ||||
| Male | 88 (72.1) | 123 (77.4) | ||
| Female | 34 (27.9) | 36 (22.6) | χ2 = 1.008 | 0.315 |
| Age (years), median (range) | 54 (48–60.3) | 65 (57–72) | U = 4392.000 | < 0.001 |
| No. of smokers data missing for 7 MM patients | 13 (10.7) | 80 (52.6) | χ2 = 53.185 | < 0.001 |
| Asbestos exposure data missing for 8 MM patients | ||||
| No | 0 (0.0) | 25 (16.6) | ||
| Yes | 122 (100.0) | 126 (83.4) | ||
| Asbestos exposure data available for all controls and 64 MM patients | ||||
| Low | 96 (78.7) | 22 (34.4) | χ2 = 35.941 | < 0.001 |
| Medium | 11 (9.0) | 21 (32.8) | ||
| High | 15 (12.3) | 21 (32.8) | ||
| Asbestos exposure data available for all controls and 64 MM patients | ||||
| Low | 96 (78.7) | 22 (34.4) | χ2 = 35.451 | < 0.001 |
| Medium and high | 26 (21.3) | 42 (65.6) |
Gene-gene interactions between rs1800566 NAD(P)H quinone dehydrogenase 1 (NQO1), rs1001179 catalase (CAT), rs4880 superoxide dismutase 2 (SOD2), and rs1052133 human 8-oxoguanine glycosylase 1 (hOGG1)
| Gene 1 | Gene 2 | Interaction | |||||
|---|---|---|---|---|---|---|---|
| 1.37 | 0.225 | 1.22 | 0.75 | ||||
| VS.CC | CG+GG VS.CC | (0.82–2.29) | (0.36–4.13) | ||||
| 1.35 | 0.220 | 1.37 | 0.225 | ||||
| CT+TT VS.CC | (0.84-2.17) | CG+GG VS.CC | (0.82–2.29) | ||||
| 0.89 | 0.661 | 1.37 | 0.225 | 0.78 | 0.669 | ||
| CT+TT VS.CC | (0.52–1.52) | CG + GG VS.CC | (0.82–2.29) | (0.25–2.43) |
The influence of interactions between the investigated polymorphisms and asbestos exposure on risk of malignant mesothelioma
| Polymorphism | OR | CI (95%) | p |
|---|---|---|---|
| 1.56 | 0.35–6.86 | 0.560 | |
| 1.57 | 0.39–6.29 | 0.522 | |
| 1.13 | 0.24–5.18 | 0.880 | |
| 0.50 | 0.12–2.14 | 0.352 |